Probing connectivity between transcriptional and post-transcriptional gene networks

Abstract

The foundation for much of our current understanding of eukaryotic cell biology stems from studies exploiting the combined power of this yeast’s genetic tractability and its simple growth requirements. Furthermore, access to an early complete genome in 1996 allowed yeast researchers to spearhead the move toward genome-wide studies that underpin our thinking about systems-level biology today. Indeed, the last decade has been so rich in these studies that it has become close to impossible for most biologists to interrogate the data in an unbiased fashion. The challenge for the next decade is to generate the informational tools to sort the multidimensional datasets for underlying networks.