When are metal complexes bioavailable?
Chun-Mei Zhao A B , Peter G.C. Campbell C and Kevin J. Wilkinson D E
+ Author Affiliations
- Author Affiliations
A School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, P.R. China.
B Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, Guangzhou 510275, P.R. China.
C Institut National de la Recherche Scientifique – Eau, Terre et Environnement (INRS-ETE), 490 Rue de la Couronne, Quebec, QC, G1K 9A9, Canada.
D Biophysical Environmental Chemistry Group, Department of Chemistry, University of Montreal, CP 6128 Succursale Centre-ville, Montreal, QC, H3C 3J7, Canada.
E Corresponding author: Email: kj.wilkinson@umontreal.ca
Chun-Mei Zhao is an associate professor at Sun Yat-Sen University. Her research interests include an examination of the environmental behaviour of trace metals and nanoparticles in the aquatic environment. She is especially interested by the influence of environmental factors on bioavailability and toxicity of trace metals and nanoparticles. Currently, her research is focussed on the speciation and bioavailability of rare earth elements in freshwater ecosystems and those affected by mining. |
Peter Campbell completed a Ph.D. at Queen’s University (Kingston, ON) in organometallic chemistry prior to spending 2 years at Monash University working with Professor John Swan in the area of organophosphorus chemistry. In 1970, he took up a position at the Institut National de la Recherche Scientifique (Université du Québec, INRS-ETE), where he is currently a Professor. Peter was elected to the Academy of Sciences of the Royal Society of Canada in 2002. His research interests focus on metals in the aquatic environment and include elements of analytical chemistry, geochemistry and ecotoxicology, where he has made a very important and sustained impact. This special issue is a recognition of the very important body of work of Peter Campbell. |
Kevin J. Wilkinson is a Professor at the Université de Montréal. His research is aimed at gaining a molecular-level understanding of contaminant bioavailability and mobility. Kevin is especially interested in examining the mobility and bioavailability of both metals and engineered nanomaterials in the environment. His research group also focuses on the development of analytical techniques designed to better understand environmental processes, including those looking at trace metal speciation or nanoparticle detection. Kevin is currently an Editor of Environmental Chemistry. |
Environmental Chemistry 13(3) 425-433 https://doi.org/10.1071/EN15205
Submitted: 29 September 2015 Accepted: 23 November 2015 Published: 2 March 2016
Journal Compilation © CSIRO Publishing 2016 Open Access CC BY-NC-ND
Environmental context. The concentration of a free metal cation has proved to be a useful predictor of metal bioaccumulation and toxicity, as represented by the free ion activity and biotic ligand models. However, under certain circumstances, metal complexes have been shown to contribute to metal bioavailability. In the current mini-review, we summarise the studies where the classic models fail and organise them into categories based on the different uptake pathways and kinetic processes. Our goal is to define the limits within which currently used models such as the biotic ligand model (BLM) can be applied with confidence, and to identify how these models might be expanded.
Abstract. Numerous data from studies over the past 30 years have shown that metal uptake and toxicity are often best predicted by the concentrations of free metal cations, which has led to the development of the largely successful free-ion activity model (FIAM) and biotic ligand model (BLM). Nonetheless, some exceptions to these classical models, showing enhanced metal bioavailability in the presence of metal complexes, have also been documented, although it is not yet fully understood to what extent these exceptions can or should be generalised. Only a few studies have specifically measured the bioaccumulation or toxicity of metal complexes while carefully measuring or controlling metal speciation. Fewer still have verified the fundamental assumptions of the classical models, especially when dealing with metal complexes. In the current paper, we have summarised the exceptions to classical models and categorised them into five groups based on the fundamental uptake pathways and kinetic processes. Our aim is to summarise the mechanisms involved in the interaction of metal complexes with organisms and to improve the predictive capability of the classic models when dealing with complexes.
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