New approach methodologies (NAMs) are defined as any technology, methodology or approach that replaces or reduces animal use for chemical risk assessment. These include various in silico, in chemico and in vitro methods, high-throughput screening and omics-based approaches (e.g. genomics, proteomics, transcriptomics, lipidomics), singly or in combination. With the aim to highlight NAM contributions to acceleration of fundamental and translational research in environmental chemistry and toxicology, this collection focuses on translational NAM advances and their application within an environmental context, in addition to identifying gaps in knowledge and highlighting opportunities for future activities. The development of management frameworks for the safe use and disposal of chemicals and waste represents a global grand challenge for sustainable development and protection of public health and the environment. NAM-based approaches will be essential in the future for sustainable socioeconomic development while enhancing important ethical acceptability to realise the principles of green chemistry. These new promising assessment tools with potential for high throughput capacity, can assist with addressing the increasing global challenges to enable more sustainable environmental management.

Guest Editors
Laura Langan (University of South Carolina, USA)
Thomas Miller (Brunel University London, UK)
Louis Tremblay (Manaaki Whenua–Landcare Research, New Zealand)
Bryan Brooks (Baylor University, USA)