Glutathione: its implications for animal health, meat quality, and health benefits of consumers
S. M. Liu A C and S. J. Eady BA CSIRO Livestock Industries, Private Bag 5, PO Wembley, WA 6913, Australia.
B CSIRO Livestock Industries, Locked Bag 1, Armidale, NSW 2350, Australia.
C Corresponding author. Email: shimin.liu@csiro.au
Australian Journal of Agricultural Research 56(8) 775-780 https://doi.org/10.1071/AR05053
Submitted: 16 February 2005 Accepted: 14 June 2005 Published: 25 August 2005
Abstract
There has been an increasing focus on the role of antioxidants for human health. This review outlines associations of the most predominant antioxidant, glutathione (GSH), in the body and some ageing-related diseases. Strategies to replete GSH, particularly developing animal-source food products, are discussed. Potentials to alter GSH content in the animal’s body and its possible effects on health are also explored.
Additional keywords: antioxidant, nutraceuticals, nutrition, animal breeding.
Acknowledgments
Dr C. L. White and Dr A. G. Brownlee of CSIRO Livestock Industries are gratefully thanked for their useful comments and discussions.
Adams JDJ,
Klaidman LK, Odunze IN
(1991) Alzheimer’s and Parkinson’s disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. Molecular and Chemical Neuropathology 14, 213–226.
| PubMed |
Altomare E,
Vendemiale G, Alano O
(1988) Hepatic glutathione content in patients with alcoholic and non alcoholic liver diseases. Life Sciences 43, 991–998.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Ames BN
(2004) A role for supplements in optimizing health: the metabolic tune-up. Archives of Biochemistry and Biophysics 423, 227–234.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Aw TY,
Wierzbicha GT, Jones DP
(1991) Oral glutathione increases tissue glutathione in vivo. Chemico-Biological Interactions 80, 89–97.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Badaloo A,
Reid M,
Forrester T,
Heird WC, Jahoor F
(2002) Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition. American Journal of Clinical Nutrition 76, 646–652.
| PubMed |
Belobrajdic DP,
McIntosh GH, Owens JA
(2003) Whey proteins protect more than red meat against azoxymethane induced ACF in Wistar rats. Cancer Letters 198, 43–51.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Board PG,
Morris RJH, Peter DW
(1976) The enzymes of glutathione synthesis in erythrocytes from GSH-high and GSH-low type Australian Merino sheep. International Journal of Biochemistry 7, 381–384.
| Crossref | GoogleScholarGoogle Scholar |
Bounous G
(2000) Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Research 20, 4785–4792.
| PubMed |
Boushey CJ,
Beresford SA,
Omenn GS, Motulsky AG
(1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Journal of the American Medical Association 274, 1049–1057.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Bunnell E, Pacht ER
(1993) Oxidized glutathione is increased in alveolar fluid of patients with adult respiratory distress syndrome. American Review of Respiratory Disease 148, 1174–1178.
| PubMed |
Cobiac, L ,
and
Syrette, J (2000).
Dringen R
(2000) Metabolism and functions of glutathione in brain. Progress in Neurobiology 62, 649–671.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Eady SJ
(2003) Breeding for gastrointestinal nematode resistance in sheep – panacea or patch? Journal of Parasitology 89, S215–S225.
Fang YZ,
Yang S, Wu G
(2002) Free radicals, antioxidants, and nutrition. Nutrition 18, 872–879.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Faustman C,
Chan WKM,
Schaefer DM, Havens A
(1998) Beef colour update: the role for vitamin E. Journal of Animal Science 76, 1019–1026.
| PubMed |
Finkelstein JD
(1990) Methionine metabolism in mammals. Journal of Nutritional Biochemistry 1, 228–237.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Finkelstein JD, Martin JJ
(1984) Methionine metabolism in mammals. Journal of Biological Chemistry 259, 9508–9513.
| PubMed |
Fukagawa NK,
Ajami AM, Young VR
(1996) Plasma methionine and cysteine kinetics in response to an intravenous glutathione infusion in adult humans. American Journal of Physiology, Endocrinology and Metabolism 270, E209–E214.
Hagen TM,
Wierszicka GT,
Sillau AH,
Bowman BB, Jones DP
(1990) Bioavailability of dietary glutathione: effect on plasma concentration. American Journal of Physiology 259, G524–G529.
| PubMed |
Hammond AH,
Garle MJ,
Sooriakumaran P, Fry JR
(2002) Modulation of hepatocyte thiol content by medium composition: implication for toxicity studies. Toxicology in Vitro 16, 259–265.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Hogg N
(1999) The effect of cyst(e)ine on the auto-oxidation of homocysteine. Free Radical Biology and Medicine 27, 28–33.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Hohenboken WD,
Morris CA,
Munday R,
De Nicolo G,
Amyes NC, Towers NR
(2004) Antioxidants in blood from sheep lines divergently selected for facial eczema resistance. New Zealand Journal of Agricultural Research 47, 119–127.
Hopkins GJ,
Roberts J, Evans JV
(1974) Red blood cell concentrations of reduced glutathione and potassium as biochemical markers of wool growth in Merino sheep. Journal of Agricultural Science, Cambridge 84, 481–486.
Hunjan MK, Evered DF
(1985) Absorption of glutathione from the gastro-intestinal tract. Biochimica et Biophysica Acta 14, 184–188.
Jenner P
(1994) Oxidative damage in neurodegenerative disease. Lancet 344, 796.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Jocelyn, PG (1972).
Julius M,
Lang CA,
Gleiberman L,
Harburg E,
DiFranceisco W, Schork A
(1994) Glutathione and morbidity in a community-based sample of elderly. Journal of Clinical Epidemiology 47, 1021–1026.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Kidd PM
(1997) Glutathione: systemic protectant against oxidative and free radical damage. Alternative Medicine Review 1, 155–176.
Lander HM
(1997) An essential role for free radicals and derived species in signal transduction. FASEB Journal 11, 118–124.
| PubMed |
Lang CA,
Mills BJ,
Lang HL,
Liu MC,
Usui WM,
Richie JJ,
Mastropaolo W, Murrell SA
(2002) High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. Journal of Laboratory and Clinical Medicine 140, 413–417.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Lang CA,
Mills BJ,
Mastropaolo W, Liu MC
(2000) Blood glutathione decreases in chronic diseases. Journal of Laboratory and Clinical Medicine 135, 402–405.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Lang CA,
Naryshkin S,
Schneider DL,
Mills BJ, Lindeman RD
(1992) Low blood glutathione levels in healthy aging adults. Journal of Laboratory and Clinical Medicine 120, 720–725.
| PubMed |
Liu SM, Masters DG
(2000) Quantitative analysis of methionine and cysteine requirements for wool production of sheep. Animal Science 71, 175–185.
Liu SM,
Smith TL,
Palmer DG,
Karlsson LJE,
Besier RB, Greeff JC
(2005) Biochemical differences in Merino sheep selected for resistance against gastrointestinal nematode and genetic and nutritional effects on faecal worm egg output. Animal Science 81, 149–157.
Lobley GE,
Connell A,
Milne E,
Newman A, Ewing TA
(1994) Protein synthesis in splanchnic tissues of sheep offered two levels of intake. The British Journal of Nutrition 71, 3–12.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Lohr JB, Browning JA
(1995) Free radical involvement in neuropsychiatric illnesses. Psychopharmacology Bulletin 31, 159–165.
| PubMed |
Lomaestro BM, Malone M
(1995) Glutathione in health and diseases: pharmacotherapeutic issues. Annals of Pharmacotherapy 29, 1263–1273.
| PubMed |
Lyons J,
Rauh-Pfeiffer A,
Yu YM,
X.M. L,
Zurakowski D,
Tompkins RG,
Ajami AM,
Young VR, Castillo
(2000) Blood glutathione synthesis rates in healthy adults receiving a sulphur amino acid-free diet. Proceedings of the National Academy of Sciences of the USA 97, 5071–5076.
| Crossref |
PubMed |
Lyons J, Rauh-Pfeiffer A ,
et al
.
(2001) Cysteine metabolism and whole blood glutathione synthesis in septic paediatric patients. Critical Care Medicine 29, 870–877.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
MacRae JC,
Walker A,
Brown D, Lobley GE
(1993) Accretion of total protein and individual amino acids by organs and tissues of growth lambs and the ability of nitrogen balance techniques to quantitate protein retention. Animal Production 57, 237–245.
Mata G,
Masters DG,
Buscall D,
Street K, Schlink AC
(1995) Responses in wool growth, liveweight, glutathione and amino acids, in Merino wethers fed increasing amounts of methionine protected from degradation in the rumen. Australian Journal of Agricultural Research 46, 1189–1204.
| Crossref | GoogleScholarGoogle Scholar |
MatÉs JM,
Pérez-Gómez C, De Castro IN
(1999) Antioxidant enzymes and human diseases. Clinical Biochemistry 32, 595–603.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
McIntosh GH,
Royle PJ,
Le Leu RK,
Regester GO,
Johnson MA,
Grinsted RL,
Kenward RS, Smithers GW
(1998) Whey proteins as functional food ingredients? International Dairy Journal 8, 425–434.
| Crossref | GoogleScholarGoogle Scholar |
Meister A, Anderson ME
(1983) Glutathione. Annual Review of Biochemistry 52, 711–760.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Mercier Y,
Gatellier P, Renerre M
(2004) Lipid and protein oxidation in vitro, and antioxidant potential in meat from Charolais cows finished on pasture or mixed diet. Meat Science 66, 467–473.
| Crossref | GoogleScholarGoogle Scholar |
Nielsen JH,
Sorensen B,
Skibsted LH, Bertelsen G
(1997) Oxidation in pre-cooked minced port as influenced by chill storage of raw muscle. Meat Science 46, 191–197.
| Crossref | GoogleScholarGoogle Scholar |
Pacht ER,
Timerman AP,
Lykens MG, Merola AJ
(1991) Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome. Chest 100, 1397–1403.
| PubMed |
Reid M,
Badaloo A,
Forrester T,
Morlese JF,
Frazer M,
Heird WC, Jahoor F
(2000) In vivo rates of erythrocyte glutathione synthesis in children with severe protein-energy malnutrition. American Journal of Physiology, Endocrinology and Metabolism 278, E405–E412.
Rowe LJ,
Maddock KR,
Lonergan SM, Hoff-Lonergan E
(2004) Influence of early postmortem protein oxidation on beef quality. Journal of Animal Science 82, 785–793.
| PubMed |
Saez G,
Thornalley PJ,
Hill HA,
Hems R, Bannister JV
(1982) The production of free radicals during the autoxidation of cysteine and their effects on isolated rat hepatocytes. Biochimica et Biophysica Acta 719, 24–31.
| PubMed |
Schneider C
(2005) Chemistry and biology of vitamin E. Molecular Nutrition and Food Research 49, 7–30.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Sohal RS,
Mockett RJ, Orr WC
(2002) Mechanisms of aging: an appraisal of the oxidative stress hypothesis. Free Radical Biology and Medicine 33, 575–586.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Sohal RS, Weindruch R
(1996) Oxidative stress, caloric restriction, and aging. Science 273, 59–63.
| PubMed |
Sumner RMW,
Peter DW, Broad RG
(1978) Effect of a duodenal infusion of methionine on erythrocyte reduced glutathione of sheep. Journal of Agricultural Sciences, Cambridge 93, 241–245.
Tikkanen HO,
Hämäläinen E, Härkönen M
(1999) Significance of skeletal muscle properties on fitness, long-term physical training and serum lipids. Atherosclerosis 142, 367–378.
| Crossref | GoogleScholarGoogle Scholar | PubMed |
Tucker EM,
Kilgour L, Young JD
(1976) The genetic control of red cell glutathione deficiencies in Finnish Landrace and Tasmanian Merino sheep and in crosses between breeds. Journal of Agriculture Science, Cambridge 87, 315–323.
van Zandwijk N
(1995a) N-acetylcysteine (NAC) and glutathione (GSH): antioxidant and chemopreventive properties, with special reference to lung cancer. Journal of Cellular Biochemistry, Supplement 22, 24–32.
van Zandwijk N
(1995b) N-acetylcysteine for lung cancer prevention. Chest 107, 1437–1441.
| PubMed |
White CL,
Kumagai H, Barnes MJ
(1997) The sulphur and selenium status of pregnant ewes grazing Mediterranean pastures. Australian Journal of Agricultural Research 48, 1081–1088.
| Crossref | GoogleScholarGoogle Scholar |
Williams AJ
(1995) Wool growth. ‘Australian sheep and wool handbook’. (Ed. DJ Cottle)
pp. 224–242. (Inkata Press: Melbourne, Vic.)
Wu G,
Fang Y, Yang S
(2002) Glutathione metabolism in animals: nutritional regulation and physiological significance. Trends in Biochemistry and Physiology 9, 217–227.
Wu G,
Fang Y,
Yang YZ,
Lupton S, Turner ND
(2004) Glutathione metabolism and its implications for health. Journal of Nutrition 134, 489–492.
| PubMed |
Young JD,
Ellory JC, Tucker EM
(1976) Amino acid transport in normal and glutathione deficient sheep erythrocytes. Biochemical Journal 154, 43–48.
| PubMed |
