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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
Australian Journal of Chemistry

Australian Journal of Chemistry

Volume 76 Number 11 2023

CH23116Flow-based assembly of nucleic acid-loaded polymer nanoparticles

Zeyan Xu, Joshua McCarrol and Martina H. Stenzel 0000-0002-6433-4419
pp. 731-745

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Treatment of diseases using nucleic acid-based approaches is of increasing importance. However, these drugs need to be delivered in nanoparticles to ensure high bioavailability. To ensure the formation of well-defined nanoparticles, flow assembly is increasingly employed. In this review, we map the pathways to nucleic acid-loaded polymer-based nanoparticles prepared by flow.


Diagram showing a timeline (from 2019 to 2023) of representative preparation strategies for 3D porous MXene heterostructures with representative examples and their corresponding literature references. Strategies listed include: bidirectional freezing, ion-diffusion-induced gelatin method, coating/depositing, electrospinning, gas foaming, and supercritical CO2 drying.

Constructing a 3D structure is an effective strategy for overcoming the electrochemical performance issues of MXenes. Generally, 3D MXene structures, being rich in funcitonal groups, can improve energy storage performance by an increased specific surface area and porosity, and decreasing ion transport distance. Therefore, 3D MXene structures have great potential in high-performance energy storage and conversion applications.

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Condensed pyrazole scaffolds form the structural core of a large number of natural products and a wide range of pharmaceuticals. Herein, we explore an efficient construction of tetracyclic pyrazolo-fused carbo- and N-heterocyclic systems, in particular, naphtho-fused cycloheptapyrazolones, azepinopyrazolones, azocinopyrazolones and azoninopyrazolones, by intramolecular Friedel–Crafts cycliacylation reactions.

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Rod-like porous α-Fe2O3 with large interplanar crystal spacing was prepared by static hydrothermal treatment at 160°C and used for a symmetric supercapacitor. The synthesized α-Fe2O3 exhibits good rate capability even at 20 A g–1 in 1 mol L–1 of KOH electrolyte. (Image credit: Fan-Ming Yang.)

CH23098Green synthesis of dual-spinneret electrospun polyacrylonitrile–ZnO@β-cyclodextrin–chitosan nanofibrous nanocomposite as a novel nano-biosorbent

Sohrab Hajmohammadi, Dadkhoda Ghazanfari 0009-0007-9971-1855, Enayatollah Sheikhhosseini, Nahid Rastakhiz and Hamideh Asadollahzadeh
pp. 785-796

Flow chart of ZnO@β-cyclodextrin nanoparticle synthesis and fading color images showing effectiveness at dye removal.

This work introduces a unique nano-biosorbent made of a polyacrylonitrile–ZnO@β-cyclodextrin–chitosan nanofibrous nanocomposite. The nanocomposite’s effectiveness as a novel antibacterial and photocatalyst agent for eliminating methylene blue was evaluated. Results verified the production of the nanocomposite, which exhibited high efficiency for methylene blue removal and acceptable antibacterial activity. (Image credit: Dadkhoda Ghazanfari.)

CH23130The synthesis and manipulation of certain Diels–Alder adducts of levoglucosenone and iso-levoglucosenone

Brett Pollard 0000-0002-5148-9665, Xin Liu, Luke A. Connal, Martin G. Banwell 0000-0002-0582-475X and Michael G. Gardiner 0000-0001-6373-4253
pp. 797-811

Structural formulae of levoglucosenone and its pseudo-enantiomer iso-levoglucosenone.

In the pursuit of new monomers for the sustainable production of polymers, the biomass-derived and platform molecule levoglucosenone (LGO, 1) as well as the pseudo-enantiomeric compound iso-levoglucosenone (iso-LGO, 3) were engaged in a series of Diels–Alder cycloaddition reactions with a range of cyclic dienes. Various manipulations of the resulting adducts provided new monomeric systems likely to be suitable for polymerisation.

CH23154Synthesis and antibacterial activity of 6″-decanesulfonylacetamide-functionalised amphiphilic derivatives of amikacin and kanamycin

Dylan C. Farr, Lendl Tan, Juanelle Furness, I. Darren Grice 0000-0001-9218-457X, Nicholas P. West 0000-0003-0955-9890 and Todd A. Houston 0000-0001-9369-8804
pp. 812-820

Molecular structure of decanesulfonylacetamide–amikacin conjugate; MIC is 22 μg mL–1 against Mycobacterium tuberculosis

Two potent antitubercular compounds, one hydrophilic (amikacin) and one hydrophobic (DSA), have been combined in a single molecule and shown to retain activity against M. tuberculosis as well as selectivity relative to S. aureus activity. This has potential to improve bioavailability and circumvent resistance mechanisms. (Image credit: Todd A. Houston.)

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