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RESEARCH ARTICLE
Contents Vol 74(12)

Folic Acid-Targeted MXene Nanoparticles for Doxorubicin Loaded Drug Delivery

Zhen Liu A B , Lan Xie A , Jia Yan A , Pengfei Liu B , Huixiang Wen B and Huijun Liu https://orcid.org/0000-0002-7126-4738 A B C
+ Author Affiliations
- Author Affiliations

A Department of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan, 421001, China.

B Hunan Key Laboratory for the Design and Application of Actinide Complexes, University of South China, Hengyang, Hunan, 421001, China.

C Corresponding author. Email: liuhuijun@usc.edu.cn

Australian Journal of Chemistry 74(12) 847-855 https://doi.org/10.1071/CH21216
Submitted: 1 September 2021  Accepted: 25 October 2021   Published: 30 November 2021

Abstract

MXenes are two-dimensional (2D) materials with a large specific surface area and abundant surface functional groups. A folate receptors-targeted drug carrier was constructed based on the rich surface functional groups and high biocompatibility of MXenes. This drug carrier possesses as high as 69.9 % drug-loading capability and as long as 48 h drug release time. Tumour targeting and a pH-responsive mechanism can make MXene nanoparticles quickly accumulate in tumour sites and slowly release loads. The results showed that DOX was released in a large amount in a PBS solution at pH 4.5. Compared with the naked drug, MXenes-FA-SP@DOX has a higher cell inhibition rate and a longer drug action time at a lower concentration (less than 10 μg mg−1). This drug delivery system exhibited potential applications for the treatment of malignant tumour and this work extends the biomedical applications of MXenes in nanomedicine.

Keywords: MXenes, targeted drug carrier, folate receptors, nanoparticles, doxorubicin, pH-responsive mechanism, cancer therapy.


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