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RESEARCH ARTICLE
Contents Vol 72(12)

Three New Spongian Diterpenes from the Marine Sponge Dendrilla rosea

Joshua B. Hayton A B , Gary D. Grant C D and Anthony R. Carroll A B E F
+ Author Affiliations
- Author Affiliations

A School of Environment and Science, Griffith University, Gold Coast, Qld 4222, Australia.

B Environmental Futures Research Institute, Griffith University, Gold Coast, Qld 4222, Australia.

C School of Pharmacy and Pharmacology, Griffith University, Gold Coast, Qld 4222, Australia.

D Menzies Health Institute Queensland, Griffith University, Gold Coast, Qld 4222, Australia.

E Griffith Institute for Drug Discovery, Griffith University, Brisbane, Qld 4111, Australia.

F Corresponding author. Email: a.carroll@griffith.edu.au

Australian Journal of Chemistry 72(12) 964-968 https://doi.org/10.1071/CH19299
Submitted: 1 July 2019  Accepted: 18 September 2019   Published: 17 October 2019

Abstract

Three new diterpenes, aplyroseols 20–22 (2–4), were isolated from two specimens of the Australian marine sponge Dendrilla rosea. The structures and relative configurations of the new metabolites were elucidated from analysis of 2D NMR data. The compounds were screened for activity against Staphylococcus aureus, but were inactive at 64 µg mL−1.


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