Synthesis and Spectroscopic Properties of a Novel Bifunctional Pyrene Derivative and its Incorporation into OligoDNA*
Tomohisa Moriguchi A , Satomi Hida A , Fumio Yoneda B and Kazuo Shinozuka A CA Division of Molecular Science, School of Science and Technology, Gunma University, 1-5-1 Tenjin-cho, Kiryu 376-8515, Japan.
B Institute of Research and Development, Fujimoto Pharmaceutical Corporation, 1-3-40 Nishiotsuka, Matsubara, Osaka 580-0011, Japan.
C Corresponding author. Email: sinozuka@chem-bio.gunma-u.ac.jp
Australian Journal of Chemistry 68(2) 256-259 https://doi.org/10.1071/CH14477
Submitted: 29 July 2014 Accepted: 28 August 2014 Published: 17 October 2014
Abstract
A new pyrene derivative bearing a modifiable silyl function (electron-donating group) and cyano function (electron-withdrawing group) was synthesized as a labelling agent for biological substances. The modified pyrene exhibited a marked bathochromic shift in both absorption and fluorescence spectra. The fluorescence quantum yield of the modified pyrene was also significantly increased compared with that of the unmodified pyrene. The modified pyrene was successfully incorporated into oligoDNA.
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