Bromination of Pyrimidines: A Simple Inexpensive Method
Thomas J. Delia A B and Robin J. Hood A
+ Author Affiliations
- Author Affiliations
A Department of Chemistry, Central Michigan University, Mount Pleasant, MI 48858, USA.
B Corresponding author. Email: delia1tj@cmich.edu
Australian Journal of Chemistry 68(2) 254-255 https://doi.org/10.1071/CH14416
Submitted: 25 June 2014 Accepted: 11 August 2014 Published: 16 October 2014
Abstract
Although the introduction of halogens into the pyrimidine ring has been accomplished numerous times, the methods usually involve either specialised reagents or very aggressive conditions. This communication paper describes the introduction of bromine into position 5 of the pyrimidine ring using common inorganic salts at room temperature. An evaluation of the substituents required for successful reaction is provided.
References
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(c) See p. 349 in D. J. Brown, The Pyrimidines 1994 (John Wiley & Sons: New York, NY).
(d) See p. 350 in D. J. Brown, The Pyrimidines 1994 (John Wiley & Sons: New York, NY).
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