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REVIEW
Contents Vol 67(6)

Fungal Metabolites as Pharmaceuticals

Andrew M. Beekman A and Russell A. Barrow A B
+ Author Affiliations
- Author Affiliations

A Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.

B Corresponding author. Email: rab@anu.edu.au




Andrew Beekman is currently a postdoctoral researcher at the Australian National University. Andrew studied for his B.Sc.(Adv.) at the Australian National University and received an Honours degree in 2009. He began his Ph.D. studies in 2010 with Dr Russell Barrow at the Research School of Chemistry as an Alan Sargeson Scholar, focusing on the elucidation and synthesis of biologically significant fungal metabolites from traditional medicinal sources, completing his thesis in 2013. In 2014, he will begin an Endeavour Postdoctoral Research Fellowship at the University of British Columbia


Russell Barrow is a group leader (Organic Chemistry of Natural Systems) at the Research School of Chemistry, Australian National University. After completing B.Sc.(Hons.) and Ph.D. degrees at Melbourne University, he undertook postdoctoral research at The University of Hawaii, focusing on the isolation and synthesis of natural products. Current research interests include studying the chemistry supporting the traditional use of fungi in Papua New Guinea, where he has an adjunct appointment at the University of Goroka.

Australian Journal of Chemistry 67(6) 827-843 https://doi.org/10.1071/CH13639
Submitted: 19 November 2013  Accepted: 4 March 2014   Published: 19 May 2014

Abstract

Natural products, their derivatives or compounds based on natural product leads constitute ~50 % of clinically used pharmaceuticals. This review highlights pharmaceuticals currently used in Australia and New Zealand that have their origins in fungal metabolites, discussing the natural products chemistry and medicinal chemistry leading to their application as pharmaceuticals.


References

[1]  D. L. Hawksworth, Mycol. Res. 1991, 95, 641.
         | Crossref | GoogleScholarGoogle Scholar |

[2]  M. Blackwell, Am. J. Bot. 2011, 98, 426.
         | Crossref | GoogleScholarGoogle Scholar | 21613136PubMed |

[3]  P. M. Kirk, P. F. Cannon, D. W. Minter, J. A. Stalpers, Dictionary of the Fungi, 10th edn 2008 (CABI: Wallingford, UK).

[4]  (a) M. S. Butler, J. Nat. Prod. 2004, 67, 2141.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhtVSmtLvK&md5=6ec0334d120e3f76423729ee28d0a7adCAS | 15620274PubMed |
      (b) B. B. Mishra, V. K. Tiwari, Eur. J. Med. Chem. 2011, 46, 4769.
         | Crossref | GoogleScholarGoogle Scholar |
      (c) D. J. Newman, G. M. Cragg, J. Nat. Prod. 2012, 75, 311.
         | Crossref | GoogleScholarGoogle Scholar |
      (d) A. L. Harvey, Drug Discov. Today 2008, 13, 894.
         | Crossref | GoogleScholarGoogle Scholar |

[5]  J. W.-H. Li, J. C. Vederas, Science 2009, 325, 161.
         | Crossref | GoogleScholarGoogle Scholar |

[6]  K. J. Weissman, P. F. Leadlay, Nat. Rev. Microbiol. 2005, 3, 925.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXht1OnsLbE&md5=e0162022daba7e6f32c6ce38748b74d9CAS | 16322741PubMed |

[7]  W. Sneader, Drug Discovery: A History 2005 (John Wiley & Sons Ltd: Chichester, UK).

[8]  N. A. McGrath, M. Brichacek, J. T. Njardarson, J. Chem. Educ. 2010, 87, 1348.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXht1aqsb%2FP&md5=da6bf9465c9364d4e654c588f440a6a3CAS |

[9]  P. R. Carroll, in MIMS Australia Annual 2014 2014 (UBM Medica Australia: Sydney, Australia).

[10]  G. Swannick, in MIMS New Zealand Annual 2014 2014 (MIMS (NZ) Ltd: Auckland, New Zealand).

[11]  Therapeutic Goods Administration, Australian Register of Therapeutic Goods, 5 July 2013 edn 2013 (Department of Health, Australian Government: Canberra, Australia). Available at http://www.tga.gov.au/industry/artg.htm (accessed 27 February 2014).

[12]  MEDSAFE, New Zealand Medicines and Medical Devices Safety Authority Register, 9 January 2014 edn 2014 (The Ministry of Health, New Zealand Government: Wellington, New Zealand). Available at http://www.medsafe.govt.nz/ (accessed 27 February 2014).

[13]  D. L. Paterson, R. A. Bonomo, Clin. Microbiol. Rev. 2005, 18, 657.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXht1Wrsr%2FE&md5=68b657a123a5ead028699f935ddcd850CAS | 16223952PubMed |

[14]  K. Crawford, N. G. Heatley, P. F. Boyd, C. W. Hale, B. K. Kelly, G. A. Miller, N. Smith, J. Gen. Microbiol. 1952, 6, 47.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaG38XmtFegsQ%3D%3D&md5=3d5d80b72a4d0eb65517a785e2a8f2ffCAS | 14927850PubMed |

[15]  G. G. F. Newton, E. P. Abraham, Nature 1953, 172, 395.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaG2cXmsVWmtg%3D%3D&md5=e09223ed290bf41627deba7702fb1bc5CAS |

[16]  G. G. F. Newton, E. P. Abraham, Nature 1955, 175, 548.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaG2MXmvFKjtw%3D%3D&md5=2b50e430f2ce64987887e972dc9f20d2CAS | 1:CAS:528:DyaG2MXmvFKjtw%3D%3D&md5=2b50e430f2ce64987887e972dc9f20d2CAS |

[17]  B. Loder, G. G. Newton, E. P. Abraham, Biochem. J. 1961, 79, 408.
         | 1:CAS:528:DyaF38XhtlSjsA%3D%3D&md5=b1039afa0f8a2dcafff2f517690f4705CAS |
         | 1:CAS:528:DyaF38XhtlSjsA%3D%3D&md5=b1039afa0f8a2dcafff2f517690f4705CAS | 13763020PubMed |

[18]  R. B. Morin, B. G. Jackson, E. H. Flynn, R. W. Roeske, J. Am. Chem. Soc. 1962, 84, 3400.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF38XkslGqtrk%3D&md5=44cca7e5d966cc0490bbf97a718302deCAS | 1:CAS:528:DyaF38XkslGqtrk%3D&md5=44cca7e5d966cc0490bbf97a718302deCAS |

[19]  E. P. Abraham, G. G. F. Newton, K. Crawford, H. S. Burton, C. W. Hale, Nature 1953, 171, 343.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaG2cXhtFSlsQ%3D%3D&md5=899a3e9bf64490c503eedb4a6371a976CAS | 1:CAS:528:DyaG2cXhtFSlsQ%3D%3D&md5=899a3e9bf64490c503eedb4a6371a976CAS | 13036884PubMed |

[20]  R. R. Chauvette, E. H. Flynn, B. G. Jackson, E. R. Lavagnino, R. B. Morin, R. A. Mueller, R. P. Pioch, R. W. Roeske, C. W. Ryan, J. L. Spencer, E. Van Heyningen, J. Am. Chem. Soc. 1962, 84, 3401.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF38XkvVels7Y%3D&md5=1686109f23c7350befaf9d0e7e4ef009CAS | 1:CAS:528:DyaF38XkvVels7Y%3D&md5=1686109f23c7350befaf9d0e7e4ef009CAS |

[21]  C. W. Ryan, R. L. Simon, E. M. Van Heyningen, J. Med. Chem. 1969, 12, 310.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF1MXps1OgsQ%3D%3D&md5=7aa0201891092d7597af2c534190ed6eCAS | 1:CAS:528:DyaF1MXps1OgsQ%3D%3D&md5=7aa0201891092d7597af2c534190ed6eCAS | 5783607PubMed |

[22]  K. Kariyone, H. Harada, M. Kurita, T. Takano, J. Antibiot. 1970, 23, 131.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE3cXktFCkuro%3D&md5=25cd92a38c7592e66922744c01d88f49CAS | 1:CAS:528:DyaE3cXktFCkuro%3D&md5=25cd92a38c7592e66922744c01d88f49CAS | 5460274PubMed |

[23]  C. H. O’Callaghan, R. B. Sykes, A. Griffiths, J. E. Thornton, Antimicrob. Agents Chemother. 1976, 9, 511.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE28Xhs1Sjurc%3D&md5=2b364a9fedd35455d6540bd0e4b10173CAS | 1:CAS:528:DyaE28Xhs1Sjurc%3D&md5=2b364a9fedd35455d6540bd0e4b10173CAS | 1259407PubMed |

[24]  S. M. Harding, P. E. Williams, J. Ayrton, Antimicrob. Agents Chemother. 1984, 25, 78.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2cXps1SksQ%3D%3D&md5=de96a788e881901365acb161d59a371dCAS | 1:CAS:528:DyaL2cXps1SksQ%3D%3D&md5=de96a788e881901365acb161d59a371dCAS | 6703686PubMed |

[25]  R. R. Chauvette, P. A. Pennington, J. Med. Chem. 1975, 18, 403.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE2MXktVWgurY%3D&md5=16a61252c298d601085a1fdd4e634a4cCAS | 1:CAS:528:DyaE2MXktVWgurY%3D&md5=16a61252c298d601085a1fdd4e634a4cCAS | 1091736PubMed |

[26]  R. Wise, T. Rollason, M. Logan, J. M. Andrews, K. A. Bedford, Antimicrob. Agents Chemother. 1978, 14, 807.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE1MXotFCrsw%3D%3D&md5=3d4e6e05d78d08941587f1de2a9ccee6CAS | 1:CAS:528:DyaE1MXotFCrsw%3D%3D&md5=3d4e6e05d78d08941587f1de2a9ccee6CAS | 253572PubMed |

[27]  R. Reiner, U. Weiss, U. Brombacher, P. Lanz, M. Montavon, A. Furlenmeier, P. Angehrn, P. J. Probst, J. Antibiot. 1980, 33, 783.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3MXktF2gug%3D%3D&md5=035075bb670be151c434913c28958936CAS | 1:CAS:528:DyaL3MXktF2gug%3D%3D&md5=035075bb670be151c434913c28958936CAS | 6967869PubMed |

[28]  C. H. O’Callaghan, P. Acred, P. B. Harper, D. M. Ryan, S. M. Kirby, S. M. Harding, Antimicrob. Agents Chemother. 1980, 17, 876.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3cXkvVyrurY%3D&md5=59a172dc88abd37df09e758b4e7e946fCAS | 1:CAS:528:DyaL3cXkvVyrurY%3D&md5=59a172dc88abd37df09e758b4e7e946fCAS | 6994642PubMed |

[29]  R. E. Kessler, M. Bies, R. E. Buck, D. R. Chisholm, T. A. Pursiano, Y. H. Tsai, M. Misiek, K. E. Price, F. Leitner, Antimicrob. Agents Chemother. 1985, 27, 207.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2MXktVemtbY%3D&md5=0d7f342cb32278af8a80dee1347187bcCAS | 3885849PubMed |

[30]  K. P. Link, Circulation 1959, 19, 97.
         | Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaG1M%2FkvVGltA%3D%3D&md5=e20a9728c636c438b9092e979b77ff53CAS | 13619027PubMed |

[31]  M. A. Stahmann, C. F. Huebner, K. P. Link, J. Biol. Chem. 1941, 138, 513.
         | 1:CAS:528:DyaH3MXislOiuw%3D%3D&md5=bb6b2b84f8b7055bff4b731f7a67719dCAS |

[32]  M. Ikawa, M. A. Stahmann, K. P. Link, J. Am. Chem. Soc. 1944, 66, 902.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaH2cXislWgug%3D%3D&md5=19c8e76a51a42429bb18bd8780c35415CAS |

[33]  R. S. Overman, M. A. Stahmann, C. F. Huebner, W. R. Sullivan, L. Spero, D. G. Doherty, M. Ikawa, L. Graf, S. Roseman, K. P. Link, J. Biol. Chem. 1944, 153, 5.
         | 1:CAS:528:DyaH2cXisFGhsg%3D%3D&md5=1597013826e0682b4349055d7157c90fCAS |

[34]  M. Ikawa, M. A. Stahmann, K. P. Link, J. Am. Chem. Soc. 1944, 66, 902.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaH2cXislWgug%3D%3D&md5=19c8e76a51a42429bb18bd8780c35415CAS |

[35]  W. R. Porter, J. Comput. Aided Mol. Des. 2010, 24, 553.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXnsFGqtLo%3D&md5=b67a30eee4e913601a8a9b4fab6bad07CAS | 20352297PubMed |

[36]  A. M. Holbrook, J. A. Pereira, R. Labiris, H. McDonald, J. D. Couketis, M. Crowther, P. S. Wells, Arch. Intern. Med. 2005, 165, 1095.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXlsFaju78%3D&md5=4e90252f1fee320acd5ce8147fe89edbCAS | 15911722PubMed |

[37]  P. R. Twentyman, Biochem. Pharmacol. 1992, 43, 109.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK38Xht1Shtrc%3D&md5=35d82e9d88a29f74bafc3c5dbf0b7b74CAS | 1346494PubMed |

[38]  H. F. Stähelin, Experientia 1996, 52, 5.
         | Crossref | GoogleScholarGoogle Scholar | 8575558PubMed |

[39]  H. Svarstad, H. Bugge, S. Dhillion, Biodivers. Conserv. 2000, 9, 1521.
         | Crossref | GoogleScholarGoogle Scholar |

[40]  T. J. Petcher, H.-P. Weber, A. Rüegger, Helv. Chim. Acta 1976, 59, 1480.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE28XkvVGrtLg%3D&md5=b51a92a9ce5bf58f65dbf02e0f968f43CAS | 931750PubMed |

[41]  R. M. Wenger, Helv. Chim. Acta 1984, 67, 502.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2cXktlyku7Y%3D&md5=a9851a8df6f2f6926e9d4f674a8280cdCAS |

[42]  X. Wu, J. L. Stockdill, P. Wang, S. J. Danishefsky, J. Am. Chem. Soc. 2010, 132, 4098.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXis1Oqtbg%3D&md5=0b5f9e01a4f765c4e2c4ae72eaeb97b3CAS | 20199071PubMed |

[43]  Y. M. Angell, T. L. Thomas, G. R. Flentke, D. H. Rich, J. Am. Chem. Soc. 1995, 117, 7279.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXmvVehu7Y%3D&md5=323312ef22712e9298abe8893908efabCAS | 1:CAS:528:DyaK2MXmvVehu7Y%3D&md5=323312ef22712e9298abe8893908efabCAS |

[44]  J. A. Smulik, S. T. Diver, F. Pan, J. O. Liu, Org. Lett. 2002, 4, 2051.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xjs1Ggu7s%3D&md5=8dc5ba7471f555dc411bfff2c4488268CAS | 1:CAS:528:DC%2BD38Xjs1Ggu7s%3D&md5=8dc5ba7471f555dc411bfff2c4488268CAS | 12049515PubMed |

[45]  A. Billich, R. Zocher, J. Biol. Chem. 1987, 262, 17258.
         | 1:CAS:528:DyaL2sXmtFKisr0%3D&md5=d1d4525efe52b3aab13f97c1b4861b2fCAS |
         | 1:CAS:528:DyaL2sXmtFKisr0%3D&md5=d1d4525efe52b3aab13f97c1b4861b2fCAS | 3693349PubMed | 3693349PubMed |

[46]  S. C. Deresinski, D. A. Stevens, Clin. Infect. Dis. 2003, 36, 1445.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXltlKnu7g%3D&md5=de744e98f2d2a5bee08464c72b3063f8CAS | 1:CAS:528:DC%2BD3sXltlKnu7g%3D&md5=de744e98f2d2a5bee08464c72b3063f8CAS | 12766841PubMed | 12766841PubMed |

[47]  D. W. Denning, Lancet 2003, 362, 1142.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXnvVKrtbo%3D&md5=16115e28f84ef3deeed79f2ac1a10ac2CAS | 1:CAS:528:DC%2BD3sXnvVKrtbo%3D&md5=16115e28f84ef3deeed79f2ac1a10ac2CAS | 14550704PubMed | 14550704PubMed |

[48]  F. Benz, F. Knüsel, J. Nüesch, H. Treichler, W. Voser, R. Nyfeler, W. Keller-Schierlein, Helv. Chim. Acta 1974, 57, 2459.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE2MXhtVyms74%3D&md5=f61c47e98293d43a4850c1719b3041d9CAS | 1:CAS:528:DyaE2MXhtVyms74%3D&md5=f61c47e98293d43a4850c1719b3041d9CAS |

[49]  C. Keller-Juslén, M. Kuhn, H. R. Loosli, T. J. Petcher, H. P. Weber, A. von Wartburg, Tetrahedron Lett. 1976, 17, 4147.
         | Crossref | GoogleScholarGoogle Scholar |

[50]  S. A. Osmani, P. M. Mirabito, Fungal Genet. Biol. 2004, 41, 401.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhslenu7o%3D&md5=266981eb42828a9a8685ac6a5e1b2810CAS | 1:CAS:528:DC%2BD2cXhslenu7o%3D&md5=266981eb42828a9a8685ac6a5e1b2810CAS | 14998523PubMed | 14998523PubMed |

[51]  T. Emri, L. Majoros, V. Tóth, I. Pócsi, Appl. Microbiol. Biotechnol. 2013, 97, 3267.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXlt1ajtr4%3D&md5=e28a2f75ae61549c791e1fd05961391fCAS | 1:CAS:528:DC%2BC3sXlt1ajtr4%3D&md5=e28a2f75ae61549c791e1fd05961391fCAS | 23463246PubMed | 23463246PubMed |

[52]  R. E. Schwartz, D. F. Sesin, H. Joshua, K. E. Wilson, A. J. Kempf, K. A. Goklen, D. Kuehner, P. Gailliot, C. Gleason, R. White, J. Antibiot. 1992, 45, 1853.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3sXhs1Crsb0%3D&md5=d49650d8cf4db77ffc75548f1e201a5cCAS | 1:CAS:528:DyaK3sXhs1Crsb0%3D&md5=d49650d8cf4db77ffc75548f1e201a5cCAS | 1490876PubMed | 1490876PubMed |

[53]  F. A. Bouffard, R. A. Zambias, J. F. Dropinski, J. M. Balkovec, M. L. Hammond, G. K. Abruzzo, K. F. Bartizal, J. A. Marrinan, M. B. Kurtz, J. Med. Chem. 1994, 37, 222.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXitlGguro%3D&md5=70ad6e5799c7d66719a9f33a2a6715d7CAS | 1:CAS:528:DyaK2cXitlGguro%3D&md5=70ad6e5799c7d66719a9f33a2a6715d7CAS | 8295208PubMed | 8295208PubMed |

[54]  M. B. Kurtz, C. Douglas, J. Marrinan, K. Nollstadt, J. Onishi, S. Dreikorn, J. Milligan, S. Mandala, J. Thompson, J. M. Balkovec, Antimicrob. Agents Chemother. 1994, 38, 2750.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXisVCrsLg%3D&md5=5adbc46497bdcb3493d894aa27544142CAS | 1:CAS:528:DyaK2MXisVCrsLg%3D&md5=5adbc46497bdcb3493d894aa27544142CAS | 7695257PubMed | 7695257PubMed |

[55]  H. Takeshima, J. Inokoshi, Y. Takada, H. Tanaka, S. Ōmura, J. Biochem. 1989, 105, 606.
         | 1:CAS:528:DyaL1MXktlGntbg%3D&md5=6f6c6f59d92c0f1df09d9b5df88b2e8eCAS |
         | 1:CAS:528:DyaL1MXktlGntbg%3D&md5=6f6c6f59d92c0f1df09d9b5df88b2e8eCAS | 2760018PubMed | 2760018PubMed |

[56]  C. Wallwey, S.-M. Li, Nat. Prod. Rep. 2011, 28, 496.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXitlKquro%3D&md5=ffaaaf07abadcaa3287b1b6c7ba06427CAS | 1:CAS:528:DC%2BC3MXitlKquro%3D&md5=ffaaaf07abadcaa3287b1b6c7ba06427CAS | 21186384PubMed |

[57]  A. Hofmann, Discoveries in Biological Psychiatry 1970 (J. B. Lippincott & Co.: Philadelphia, USA).

[58]  A. J. A. de Groot, P. J. Dongen, T. Vree, Y. Hekster, J. Roosmalen, Drugs 1998, 56, 523.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXnsVWis74%3D&md5=a05bea5f1278e18c36c8d4a4b0678415CAS | 1:CAS:528:DyaK1cXnsVWis74%3D&md5=a05bea5f1278e18c36c8d4a4b0678415CAS |

[59]  A. Stoll, A. Hofmann, Helv. Chim. Acta 1943, 26, 2070.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaH2cXjtFaisA%3D%3D&md5=dfb0c961372fa61b80e1870a2788a5b2CAS | 1:CAS:528:DyaH2cXjtFaisA%3D%3D&md5=dfb0c961372fa61b80e1870a2788a5b2CAS |

[60]  I. Colman, M. D. Brown, G. D. Innes, E. Grafstein, T. E. Roberts, B. H. Rowe, Ann. Emerg. Med. 2005, 45, 393.
         | Crossref | GoogleScholarGoogle Scholar | 15795718PubMed |

[61]  P. A. Stadler, A. J. Frey, F. Troxler, A. Hofmann, Helv. Chim. Acta 1964, 47, 756.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF2cXptFSlsA%3D%3D&md5=b908f038444eb8fbc0d4498ef919e475CAS | 1:CAS:528:DyaF2cXptFSlsA%3D%3D&md5=b908f038444eb8fbc0d4498ef919e475CAS |

[62]  A. Stoll, A. Hofmann, Helv. Chim. Acta 1943, 26, 944.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaH2cXhtVWgsw%3D%3D&md5=a9a244368955a35133e4f3401b3b9362CAS | 1:CAS:528:DyaH2cXhtVWgsw%3D%3D&md5=a9a244368955a35133e4f3401b3b9362CAS |

[63]  V. Zikán, M. Semonský, Collect. Czech. Chem. Commun. 1960, 25, 1922.
         | Crossref | GoogleScholarGoogle Scholar |

[64]  D. Marona-Lewicka, D. Kurrasch-Orbaugh, J. Selken, M. Cumbay, J. Lisnicchia, D. Nichols, Psychopharmacology 2002, 164, 93.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xns1Ogtr8%3D&md5=4d2be016c22a29d27b37b0220aaba2edCAS | 1:CAS:528:DC%2BD38Xns1Ogtr8%3D&md5=4d2be016c22a29d27b37b0220aaba2edCAS | 12373423PubMed |

[65]  E. C. Kornfeld, N. J. Bach, Vol. US4166182 A, Eli Lilly and Co., USA. 1979, p. 71.

[66]  S. P. Markey, R. W. Colburn, I. J. Kopin, J. Labelled Comp. Radiopharm. 1976, 12, 627.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE2sXhtVKrtL8%3D&md5=26f020ab4e502d70bb3ff6b4fcf87ac0CAS | 1:CAS:528:DyaE2sXhtVKrtL8%3D&md5=26f020ab4e502d70bb3ff6b4fcf87ac0CAS |

[67]  D. B. Calne, P. N. Leigh, P. F. Teychenne, A. N. Bamji, J. K. Greenacre, Lancet 1974, 304, 1355.
         | Crossref | GoogleScholarGoogle Scholar |

[68]  M. A. Via, H. Chandra, T. Araki, M. Potenza, M. Skamagas, Diabetes Metab. Syndr. Obes. Target Ther. 2010, 3, 43.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXkt1Crtbo%3D&md5=93abc9141ae9a3dcd44ca40e170bebd0CAS | 1:CAS:528:DC%2BC3cXkt1Crtbo%3D&md5=93abc9141ae9a3dcd44ca40e170bebd0CAS |

[69]  E. Brambilla, E. Disalle, G. Briatico, S. Mantegani, A. Temperilli, Eur. J. Med. Chem. 1989, 24, 421.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3cXhsl2mtr0%3D&md5=c95fbefc4ee24c02770ce8c61cf3a30aCAS | 1:CAS:528:DyaK3cXhsl2mtr0%3D&md5=c95fbefc4ee24c02770ce8c61cf3a30aCAS |

[70]  S. W. Ashford, K. E. Henegar, A. M. Anderson, P. G. M. Wuts, J. Org. Chem. 2002, 67, 7147.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XmvVykurY%3D&md5=052a6d6f69faf1196a34a6a2ab939c9aCAS | 1:CAS:528:DC%2BD38XmvVykurY%3D&md5=052a6d6f69faf1196a34a6a2ab939c9aCAS | 12354014PubMed | 12354014PubMed |

[71]  V. Brinkmann, A. Billich, T. Baumruker, P. Heining, R. Schmouder, G. Francis, S. Aradhye, P. Burtin, Nat. Rev. Drug Discov. 2010, 9, 883.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtlCqsr%2FL&md5=9cdabde62c3fdb2a44fcc3e13d447493CAS | 1:CAS:528:DC%2BC3cXhtlCqsr%2FL&md5=9cdabde62c3fdb2a44fcc3e13d447493CAS | 21031003PubMed | 21031003PubMed |

[72]  D. Kluepfel, J. Bagli, H. Baker, M. P. Charest, A. Kudelski, S. N. Sehgal, C. Vezina, J. Antibiot. 1972, 25, 109.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE38Xhtlyqtbg%3D&md5=a90fb20bb77827e61819789541e5ef6dCAS | 5034807PubMed | 5034807PubMed |

[73]  T. Fujita, M. Yoneta, R. Hirose, S. Sasaki, K. Inoue, M. Kiuchi, S. Hirase, K. Adachi, M. Arita, K. Chiba, Bioorg. Med. Chem. Lett. 1995, 5, 847.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXlsVGiurc%3D&md5=a7a7cb13f786bb86c5afbd0f0c355d62CAS |

[74]  K. Adachi, T. Kohara, N. Nakao, M. Arita, K. Chiba, T. Mishina, S. Sasaki, T. Fujita, Bioorg. Med. Chem. Lett. 1995, 5, 853.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXlsVGiu74%3D&md5=23463c77228b38f48a4c885363dd0718CAS | 1:CAS:528:DyaK2MXlsVGiu74%3D&md5=23463c77228b38f48a4c885363dd0718CAS |

[75]  W. O. Godtfredsen, S. Jahnsen, H. Lorck, K. Roholt, L. Tybring, Nature 1962, 193, 987.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF38XksFWrs7o%3D&md5=e968499927331235876c31b6d0af682cCAS | 1:CAS:528:DyaF38XksFWrs7o%3D&md5=e968499927331235876c31b6d0af682cCAS | 13899435PubMed |

[76]  W. O. Godtfredsen, S. Vangedal, Tetrahedron 1962, 18, 1029.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF3sXovF2i&md5=3898a691b854fe5de99ac5a1aed13c47CAS | 1:CAS:528:DyaF3sXovF2i&md5=3898a691b854fe5de99ac5a1aed13c47CAS |

[77]  D. Arigoni, W. Vondaehne, W. O. Godtfredsen, A. Marquet, A. Melera, Experientia 1963, 19, 521.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF2cXjsFWq&md5=efdd5517a18d48b88ea2bf001c6577dbCAS | 1:CAS:528:DyaF2cXjsFWq&md5=efdd5517a18d48b88ea2bf001c6577dbCAS | 14094054PubMed | 14094054PubMed |

[78]  R. Bucourt, M. Legrand, M. Vignau, J. Tessier, V. Delaroff, C. R. Chimie 1963, 257, 2679.
         | 1:CAS:528:DyaF2cXitlKisA%3D%3D&md5=37e6f1dbde2de3917b8498f49f14a298CAS |
         | 1:CAS:528:DyaF2cXitlKisA%3D%3D&md5=37e6f1dbde2de3917b8498f49f14a298CAS |

[79]  (a) W. G. Dauben, G. Ahlgren, T. J. Leitereg, W. C. Schwarzel, M. Yoshioko, J. Am. Chem. Soc. 1972, 94, 8593.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE3sXjtVSmtw%3D%3D&md5=0cc389dcb85d1bf601186893c616c9feCAS | 1:CAS:528:DyaE3sXjtVSmtw%3D%3D&md5=0cc389dcb85d1bf601186893c616c9feCAS | 4638993PubMed | 4638993PubMed |
      (b) W. G. Dauben, C. R. Kessel, M. Kishi, M. Somei, M. Tada, D. Guillerm, J. Am. Chem. Soc. 1982, 104, 303.
         | Crossref | GoogleScholarGoogle Scholar |
      (c) M. Tanabe, D. M. Yasuda, R. H. Peters, Tetrahedron Lett. 1977, 18, 1481.
         | Crossref | GoogleScholarGoogle Scholar |

[80]  M. C. Pirrung, W. L. Brown, S. Rege, P. Laughton, J. Am. Chem. Soc. 1991, 113, 8561.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3MXmsl2lt70%3D&md5=537b2ce6d17a9ed64825a25e5e404d8cCAS | 1:CAS:528:DyaK3MXmsl2lt70%3D&md5=537b2ce6d17a9ed64825a25e5e404d8cCAS |

[81]  A. E. Oxford, H. Raistrick, P. Simonart, Biochem. J. 1939, 33, 240.
         | 1:CAS:528:DyaA1MXksl2ksg%3D%3D&md5=7076842b8294c0d188bc79121d19af62CAS |
         | 1:CAS:528:DyaA1MXksl2ksg%3D%3D&md5=7076842b8294c0d188bc79121d19af62CAS | 16746904PubMed | 16746904PubMed |

[82]  J. F. Grove, J. MacMillan, T. P. C. Mulholland, J. Zealley, J. Chem. Soc. 1952, 3967.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaG3sXltFGjsg%3D%3D&md5=b145a75c35e5eb20e56b7545b558e86dCAS | 1:CAS:528:DyaG3sXltFGjsg%3D%3D&md5=b145a75c35e5eb20e56b7545b558e86dCAS |

[83]  J. MacMillan, J. Chem. Soc. 1959, 1823.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaG1MXhtFWksb4%3D&md5=fd007ed00911a5260727af6795720d21CAS | 1:CAS:528:DyaG1MXhtFWksb4%3D&md5=fd007ed00911a5260727af6795720d21CAS |

[84]  J. C. Gentles, Nature 1958, 182, 476.
         | Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaG1M%2Fgslahsw%3D%3D&md5=7b5e471b87232f252af55dadb1a09082CAS | 1:STN:280:DyaG1M%2Fgslahsw%3D%3D&md5=7b5e471b87232f252af55dadb1a09082CAS | 13577889PubMed | 13577889PubMed |

[85]  E. Finkelstein, B. Amichai, M. H. Grunwald, Int. J. Antimicrob. Agents 1996, 6, 189.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28XisFGqsL0%3D&md5=6d3bcfb96fe7b2fea3b4081d4a9e31f0CAS | 1:CAS:528:DyaK28XisFGqsL0%3D&md5=6d3bcfb96fe7b2fea3b4081d4a9e31f0CAS | 18611708PubMed | 18611708PubMed |

[86]  A. Brossi, M. Baumann, M. Gerecke, E. Kyburz, Helv. Chim. Acta 1960, 43, 1444.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF3MXit1OjsQ%3D%3D&md5=7885cf49ae3e4a9f62f3086458342d6bCAS | 1:CAS:528:DyaF3MXit1OjsQ%3D%3D&md5=7885cf49ae3e4a9f62f3086458342d6bCAS |

[87]  (a) A. C. Day, J. Nabney, A. I. Scott, J. Chem. Soc. 1961, 4067.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF38XjtFejtw%3D%3D&md5=45f71eae51010d8b120020e243c5e1b4CAS | 1:CAS:528:DyaF38XjtFejtw%3D%3D&md5=45f71eae51010d8b120020e243c5e1b4CAS |
      (b) D. Taub, C. H. Kuo, H. L. Slates, N. L. Wendler, Tetrahedron 1963, 19, 1.
         | Crossref | GoogleScholarGoogle Scholar |
      (c) S. Danishefsky, F. J. Walker, J. Am. Chem. Soc. 1979, 101, 7018.
         | Crossref | GoogleScholarGoogle Scholar |

[88]  L. N. Mander, S. P. Sethi, Tetrahedron Lett. 1983, 24, 5425.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2cXhsFGrtL0%3D&md5=40abfebeb0220ab75c3ba2b1b376d6f4CAS | 1:CAS:528:DyaL2cXhsFGrtL0%3D&md5=40abfebeb0220ab75c3ba2b1b376d6f4CAS |

[89]  B. Gosio, Riv. Igiene Sanita Pub. Ann 1896, 7, 825.

[90]  F. Ardestani, S. S. Fatemi, B. Yakhchali, S. M. Hosseyni, G. Najafpour, Biochem. Eng. J. 2010, 50, 99.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXmtlymtr0%3D&md5=4957af4811b8d46b360c3927b0d529f8CAS | 1:CAS:528:DC%2BC3cXmtlymtr0%3D&md5=4957af4811b8d46b360c3927b0d529f8CAS |

[91]  T. S. Mele, P. F. Halloran, Immunopharmacology 2000, 47, 215.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXktlKktL4%3D&md5=15946a4b252288180c1b1005262ef16aCAS | 1:CAS:528:DC%2BD3cXktlKktL4%3D&md5=15946a4b252288180c1b1005262ef16aCAS | 10878291PubMed |

[92]  W. A. Lee, L. Gu, A. R. Miksztal, N. Chu, K. Leung, P. H. Nelson, Pharm. Res. 1990, 7, 161.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3cXhs1CrtLY%3D&md5=23dfd2933bd51f6c1e68e2a317963ddaCAS | 2308896PubMed | 2308896PubMed |

[93]  H. W. Sollinger, M. H. Deierhoi, F. O. Belzer, A. G. Diethelm, R. S. Kauffman, Transplantation 1992, 53, 428.
         | Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK387ltFehtQ%3D%3D&md5=58b4a36d905c9605c095a80ca21668a6CAS | 1:STN:280:DyaK387ltFehtQ%3D%3D&md5=58b4a36d905c9605c095a80ca21668a6CAS | 1346731PubMed | 1346731PubMed |

[94]  O. Sterner, Methods Mol. Biol. 2012, 864, 393.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsFags7bL&md5=9fc6a5687b6a8e62dcefcef8b8fece9fCAS | 22367905PubMed | 22367905PubMed |

[95]  M. Shahid, F. Sobia, A. Singh, A. Malik, H. M. Khan, D. Jonas, P. M. Hawkey, Crit. Rev. Microbiol. 2009, 35, 81.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhsVyisLbO&md5=68b217dfb1ca87f18945b39e3547abdaCAS | 1:CAS:528:DC%2BD1MXhsVyisLbO&md5=68b217dfb1ca87f18945b39e3547abdaCAS | 19514910PubMed | 19514910PubMed |

[96]  H. Vanderhaeghe, P. Claes, E. Roets, R. Busson, Int. Congr. Ser. Excerpta Med. 1979, 457, 169.
         | 1:CAS:528:DyaE1MXlsFOlsLo%3D&md5=bfd33e1eb5289a67ddb07e07ec9fdf1bCAS |
         | 1:CAS:528:DyaE1MXlsFOlsLo%3D&md5=bfd33e1eb5289a67ddb07e07ec9fdf1bCAS |

[97]  G. N. Rolinson, A. M. Geddes, Int. J. Antimicrob. Agents 2007, 29, 3.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXht1Sksg%3D%3D&md5=21b8065b1ed5c2a6537f3785d4a28715CAS | 1:CAS:528:DC%2BD2sXht1Sksg%3D%3D&md5=21b8065b1ed5c2a6537f3785d4a28715CAS | 17137753PubMed | 17137753PubMed |

[98]  R. A. Sherman, M. E. Mulligan, Infect. Dis. Ther. 1994, 9, 69.
         | 1:CAS:528:DyaK2MXit1aksbY%3D&md5=b996ca3b52c03b85edd899ecd7bd0916CAS |
         | 1:CAS:528:DyaK2MXit1aksbY%3D&md5=b996ca3b52c03b85edd899ecd7bd0916CAS |

[99]  R. B. Hamed, J. R. Gomez-Castellanos, L. Henry, C. Ducho, M. A. McDonough, C. J. Schofield, Nat. Prod. Rep. 2013, 30, 21.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhvVWhtr%2FF&md5=9f6e3d99eda6a153fb5744bdead53f1eCAS | 1:CAS:528:DC%2BC38XhvVWhtr%2FF&md5=9f6e3d99eda6a153fb5744bdead53f1eCAS | 23135477PubMed |

[100]  H. F. Chambers, F. R. Deleo, Nat. Rev. Microbiol. 2009, 7, 629.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXpvFCrsLo%3D&md5=8a7977c092027dd66209dda53df1233dCAS | 1:CAS:528:DC%2BD1MXpvFCrsLo%3D&md5=8a7977c092027dd66209dda53df1233dCAS | 19680247PubMed |

[101]  O. K. Behrens, J. Corse, J. P. Edwards, L. Garrison, R. G. Jones, Q. F. Soper, F. R. Van Abeele, C. W. Whitehead, J. Biol. Chem. 1948, 175, 793.
         | 1:CAS:528:DyaH1MXhtFahtQ%3D%3D&md5=95a7d4114b3abe0b6d3830968bda9828CAS |
         | 1:CAS:528:DyaH1MXhtFahtQ%3D%3D&md5=95a7d4114b3abe0b6d3830968bda9828CAS | 18880775PubMed |

[102]  R. Reiner, Antibiotics: An Introduction 1982 (Thieme-Stratton: Stuttgart, Germany).

[103]  F. R. Batchelor, F. P. Doyle, J. H. C. Nayler, G. N. Rolinson, Nature 1959, 183, 257.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaG1MXntlSmtw%3D%3D&md5=c9e8aecb9fa3d31f24f29e8211059df3CAS | 1:CAS:528:DyaG1MXntlSmtw%3D%3D&md5=c9e8aecb9fa3d31f24f29e8211059df3CAS | 13622762PubMed | 13622762PubMed |

[104]  E. P. Abraham, E. Chain, Nature 1940, 146, 837.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaH3MXhtFejsA%3D%3D&md5=2dae5e2a454fed19ccd6af08f0a363e5CAS | 1:CAS:528:DyaH3MXhtFejsA%3D%3D&md5=2dae5e2a454fed19ccd6af08f0a363e5CAS |

[105]  F. P. Doyle, A. A. W. Long, J. H. C. Nayler, E. R. Stove, Nature 1961, 192, 1183.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF38XltlyjsQ%3D%3D&md5=62575df6afdf1835eeca4f2792d21294CAS | 1:CAS:528:DyaF38XltlyjsQ%3D%3D&md5=62575df6afdf1835eeca4f2792d21294CAS | 13887657PubMed | 13887657PubMed |

[106]  P. Acred, D. M. Brown, E. T. Knudsen, G. N. Rolinson, R. Sutherland, Nature 1967, 215, 25.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF2sXks1aru7k%3D&md5=0ff3f9eb2c20825d86d8a23b91043e1cCAS | 1:CAS:528:DyaF2sXks1aru7k%3D&md5=0ff3f9eb2c20825d86d8a23b91043e1cCAS | 6069557PubMed | 6069557PubMed |

[107]  G. P. Bodey, B. Deerhake, Appl. Microbiol. 1971, 21, 61.
         | 1:CAS:528:DyaE3MXmtF2jtg%3D%3D&md5=2784ba0a0ab30b5108d856966ddfdf0aCAS |
         | 1:CAS:528:DyaE3MXmtF2jtg%3D%3D&md5=2784ba0a0ab30b5108d856966ddfdf0aCAS | 4924999PubMed |

[108]  G. L. Drusano, S. C. Schimpff, W. L. Hewitt, Rev. Infect. Dis. 1984, 6, 13.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2cXhtlWrt7k%3D&md5=475c31dd4f569c6fc2784ebb76731a6cCAS | 6369480PubMed | 6369480PubMed |

[109]  (a) J. C. Sheehan, K. R. Henry-Logan, J. Am. Chem. Soc. 1962, 84, 2983.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF38Xks1aks74%3D&md5=fd352bae2be22c5568568ca7af1af778CAS |
      (b) J. M. Luengo, J. Antibiot. 1995, 48, 1195.
         | Crossref | GoogleScholarGoogle Scholar |
      (c) R. M. Lau, J. T. H. van Eupen, D. Schipper, G. I. Tesser, J. Verweij, E. de Vroom, Tetrahedron 2000, 56, 7601.
         | Crossref | GoogleScholarGoogle Scholar |
      (d) E. M. Scanlan, J. C. Walton, Helv. Chim. Acta 2006, 89, 2133.
         | Crossref | GoogleScholarGoogle Scholar |

[110]  J. C. Sheehan, K. R. Henery-Logan, J. Am. Chem. Soc. 1959, 81, 3089.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF3cXntFOk&md5=881724197c126acd0cf90be6ba5cda31CAS | 1:CAS:528:DyaF3cXntFOk&md5=881724197c126acd0cf90be6ba5cda31CAS |

[111]  A. Endo, K. Hasumi, Nat. Prod. Rep. 1993, 10, 541.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXht1yit7k%3D&md5=6dd0a15352a41a7fa4ddcd424dd3f2d2CAS | 8121646PubMed | 8121646PubMed |

[112]  Z. Časar, M. Steinbücher, J. Košmrlj, J. Org. Chem. 2010, 75, 6681.
         | Crossref | GoogleScholarGoogle Scholar | 20815370PubMed | 20815370PubMed |

[113]  A. Endo, M. Kuroda, Y. Tsujita, J. Antibiot. 1976, 29, 1346.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE2sXmsFKmtg%3D%3D&md5=a46149d8cceb40dd8221bb9910f84ddbCAS | 1010803PubMed | 1010803PubMed |

[114]  A. G. Brown, T. C. Smale, T. J. King, R. Hasenkamp, R. H. Thompson, J. Chem. Soc. Perkin Trans. 1 1976, 1165.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE28Xlt1eks7o%3D&md5=64553c35db506cc77a4a06113a58d59bCAS | 945291PubMed | 945291PubMed |

[115]  A. Endo, J. Antibiot. 1979, 32, 852.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE1MXmtV2htLc%3D&md5=dcee300c6f3e3871aa510f3c161bd5beCAS | 500505PubMed | 500505PubMed |

[116]  W. F. Hoffman, A. W. Alberts, P. S. Anderson, J. S. Chen, R. L. Smith, A. K. Willard, J. Med. Chem. 1986, 29, 849.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL28XhvVKhsLY%3D&md5=1e25dffdc23c4e9958ea3b4e2bad4dd4CAS | 3634830PubMed | 3634830PubMed |

[117]  A. K. Willard, R. L. Smith, J. Labelled Comp. Radiopharm. 1982, 19, 337.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL38Xlt1OgtL4%3D&md5=b9d815815dd3f2d59916b7ef7b5831c4CAS |

[118]  Y. Tsujita, M. Kuroda, Y. Shimada, K. Tanzawa, M. Arai, I. Kaneko, M. Tanaka, H. Masuda, C. Tarumi, Y. Watanabe, S. Fujii, Biochim. Biophys. Acta Lipids Lipid Metab. 1986, 877, 50.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL28Xkslansbk%3D&md5=de95a7a8c171c3dda6e1ff10b61502d6CAS |

[119]  T. Matsuoka, S. Miyakoshi, K. Tanzawa, K. Nakahara, M. Hosobuchi, N. Serizawa, Eur. J. Biochem. 1989, 184, 707.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3cXltFSjtQ%3D%3D&md5=a35e7d39698ba2a315b762d99c8cbb75CAS | 2509201PubMed | 2509201PubMed |

[120]  P. L. Anderson, F. G. Kathawala, N. A. Paolella, S. Wattanasin, Preparation of azaindole and indolizine derivatives as anticholesteremics, Patent No. WO1988001997A2, Sandoz AG, assignee 1988, p. 68.

[121]  O. Repič, K. Prasad, G. T. Lee, Org. Process Res. Dev. 2001, 5, 519.
         | Crossref | GoogleScholarGoogle Scholar |

[122]  B. D. Roth, C. J. Blankley, A. W. Chucholowski, E. Ferguson, M. L. Hoefle, D. F. Ortwine, R. S. Newton, C. S. Sekerke, D. R. Sliskovic, M. Wilson, J. Med. Chem. 1991, 34, 357.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3MXltlGrtb4%3D&md5=8d639059e3b75d4e41d0cd41cc19c300CAS | 1992137PubMed | 1992137PubMed |

[123]  M. Watanabe, H. Koike, T. Ishiba, T. Okada, S. Seo, K. Hirai, Bioorg. Med. Chem. 1997, 5, 437.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXhsVKhsL0%3D&md5=a79ca7a1f52fd9b33dc6e93f26b2ef01CAS | 9061208PubMed | 9061208PubMed |

[124]  (a) G. M. Cragg, D. J. Newman, K. M. Snader, J. Nat. Prod. 1997, 60, 52.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXitVOiug%3D%3D&md5=a74cf0cd1a4794742a044d8e360d3d81CAS | 9014353PubMed | 9014353PubMed |
      (b) D. J. Newman, G. M. Cragg, J. Nat. Prod. 2007, 70, 461.
         | Crossref | GoogleScholarGoogle Scholar |
      (c) D. J. Newman, G. M. Cragg, K. M. Snader, J. Nat. Prod. 2003, 66, 1022.
         | Crossref | GoogleScholarGoogle Scholar |

[125]  (a) C. Pearce, Adv. Appl. Microbiol. 1997, 44, 1.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXntVeisbk%3D&md5=dddc6969870d264af40f1b96bd7db797CAS | 9311104PubMed | 9311104PubMed |
      (b) I. Lanekoff, O. Geydebrekht, G. E. Pinchuk, A. E. Konopka, J. Laskin, Analyst 2013, 138, 1971.
         | Crossref | GoogleScholarGoogle Scholar |