Role of Cation in Enhancing the Conversion of the Alzheimer’s Peptide into Amyloid Fibrils Using Protic Ionic Liquids
Natalie Debeljuh B , Swapna Varghese A , Colin J. Barrow B and Nolene Byrne A C
+ Author Affiliations
- Author Affiliations
A Institute for Frontier Materials, Deakin University, Geelong, Vic. 3217, Australia.
B School of Life and Environmental Sciences, Deakin University, Geelong, Vic. 3217, Australia.
C Corresponding author. Email: nolene.byrne@deakin.edu.au
Australian Journal of Chemistry 65(11) 1502-1506 https://doi.org/10.1071/CH12316
Submitted: 5 July 2012 Accepted: 10 August 2012 Published: 2 October 2012
Abstract
We report on the impact of changes in the protic ionic liquid (pIL) cation on the fibrilisation kinetics and the conversion of the Aβ 16–22 from monomers to amyloid fibrils. When we compare the use of primary, secondary, and tertiary amines we find that the primary amine results in the greatest conversion into amyloid fibrils. We show that the pIL is directly interacting with the peptide and this likely drives the difference in conversion and kinetics observed.
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