Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-Component Reactions in Ionic Liquid

Xinying Zhang; Xiaoyan Li; Xuesen Fan; Xia Wang; Jianji Wang; Guirong Qu

doi:10.1071/CH08290

RESEARCH ARTICLE

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Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-Component Reactions in Ionic Liquid

Xinying Zhang ^A ^B , Xiaoyan Li ^A , Xuesen Fan ^A ^B , Xia Wang ^A , Jianji Wang ^A and Guirong Qu ^A

+ Author Affiliations

- Author Affiliations

^A School of Chemistry and Environmental Sciences, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University, Xinxiang, Henan 453007, China.

^B Corresponding authors. Email: xyzh518@sohu.com; xuesen.fan@yahoo.com

Australian Journal of Chemistry 62(4) 382-388 https://doi.org/10.1071/CH08290
Submitted: 9 July 2008 Accepted: 31 December 2008 Published: 24 April 2009

Abstract

A multi-component reaction of aldehyde, malononitrile, and 5-amino-3-methyl-1-phenylpyrazole was carried out smoothly in [bmim][BF₄] without any added catalyst. Through this reaction, pyrazolo[3,4-b]pyridines or substituted malononitrile derivatives were obtained conveniently and controllably at different temperatures. The ionic liquid used can be easily recovered and efficiently reused for at least five runs.

Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (No. 20772025 and No. 20873036) and Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 2008HASTIT006).

References

Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-Component Reactions in Ionic Liquid

Abstract

Acknowledgements

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