Graphisins A and B from the Lichen Graphis tetralocularis
Pattama Pittayakhajonwut A B , Veera Sri-indrasutdhi A , Aibrohim Dramae A , Sanisa Lapanun A , Rapheephat Suvannakad A and Morakot Tantichareon AA National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Paholyothin Rd., Klong Luang, Pathumthani, 12120, Thailand.
B Corresponding author. Email: pattamap@biotec.or.th
Australian Journal of Chemistry 62(4) 389-391 https://doi.org/10.1071/CH08313
Submitted: 22 July 2008 Accepted: 18 February 2009 Published: 24 April 2009
Abstract
Crude extracts of the lichen Graphis tetralocularis exhibited antimycobacterial activity, with minimum inhibitory concentration (MIC) values in a range of 100–200 μg mL–1. Chemical investigation of the broth led to the isolation of acremonidin E (1) and graphisins A (2) and B (3). Acremonidin E (1) displayed antitubercular activity with MIC values of 50 μg mL–1 and showed cytotoxicity against BC, KB, and NCI-H187 cell lines with IC50 values of 12.79–27.12 μg mL–1, whereas graphisins A (2) and B (3) were inactive to these tests.
Acknowledgements
Financial support from the Bioresources Research Network, National Center for Genetic Engineering and Biotechnology, is gratefully acknowledged. V.S. also thanks Bioresources Utilization Program supported by Biodiversity Research and Training Program (BRT) for a research grant (grant number BUP 004 G-47).
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