Long-Chained Pyridinium N-Chloramines: Synthesis and Remarkable Biocidal Efficacies for Antibacterial Application
Lingdong Li
A B C , Dongxue Jia B , Guangqing Zhang B and Hanxue Ma B
+ Author Affiliations
- Author Affiliations
A State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
B School of Chemical Engineering, Dalian University of Technology, Panjin 124221, China.
C Corresponding author. Email: lild@dlut.edu.cn
Australian Journal of Chemistry 74(5) 351-356 https://doi.org/10.1071/CH20354
Submitted: 4 December 2020 Accepted: 5 March 2021 Published: 30 March 2021
Abstract
Two types of long-chained pyridinium N-chloramines were designed and synthesised by covalent linking a N-chloramine unit and a long intact alkyl chain via varied alkylation of 3-hydroxypyridine. Preliminary antibacterial tests showed that both synthetic pyridinium N-chloramines exerted distinctively elevated biocidal efficacy in contrast to previously reported pyridinium N-chloramines that lack a long chain. Such enhanced bactericidal behaviour was probably caused by ‘synergistic’ biocidal action between the N-chloramine moiety and the long-chained pyridinium moiety.
Keywords: long-chained pyridinium salt, pyridinium N-chloramine, poly-step chemical synthesis, bactericidal application, remarkable biocidal efficacies, ‘synergistic’ biocidal effect.
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