DNA Binding and DNA Cleavage Activities of Newly Synthesized CoII and CuII Complexes of a β-Cyclodextrin Based Azo-Functionalized Schiff Base
Ananya Das A , Dipu Kumar Mishra A , Pritika Gurung A , Vikas Kumar Dakua B and Biswajit Sinha
A C
+ Author Affiliations
- Author Affiliations
A Department of Chemistry, University of North Bengal, Darjeeling-734013, India.
B Department of Chemistry, Alipurduar University, Alipurduar-736122, West Bengal, India.
C Corresponding author. Email: biswachem@gmail.com
Australian Journal of Chemistry 74(5) 341-350 https://doi.org/10.1071/CH20314
Submitted: 20 October 2020 Accepted: 14 December 2020 Published: 19 January 2021
Abstract
Two water soluble complexes with CoII and CuII ions were synthesized using a novel β-cyclodextrin based azo-functionalized Schiff base as a ligand. The Schiff base and its metal complexes were characterized by different physico-chemical and spectroscopic methods. From the analyses of the experimental data, distorted octahedral geometry has been assigned for both the metal complexes. The binding interactions between the metal complexes and DNA were investigated by means of a thermal denaturation study and viscosity measurements as well as by electronic absorption and fluorescence spectroscopy. The DNA cleavage efficacy of the metal complexes was also studied by agarose gel electrophoresis using pBR DNA. These studies revealed that both the metal complexes followed an intercalative mode of binding to calf thymus (CT)-DNA and also effectively cleaved the supercoiled pBR DNA. The CoII complex, however, more efficiently cleaved CT-DNA than the CuII complex as much as the experimental results are concerned.
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