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RESEARCH ARTICLE
Contents Vol 71(9)

Siliquapyranone: A Tannic Acid Tetrahydropyran-2-one Isolated from the Leaves of Carob (Ceratonia siliqua) by Pressurised Hot Water Extraction*

Bianca J. Deans A , Brianna E. Skierka A , Benjamin W. Karagiannakis A , Daniel Vuong B , Ernest Lacey B , Jason A. Smith A C and Alex C. Bissember orcid.org/0000-0001-5515-2878 A C
+ Author Affiliations
- Author Affiliations

A School of Natural Sciences – Chemistry, University of Tasmania, Hobart, Tas. 7001, Australia.

B Microbial Screening Technologies, Building C, 28-54 Percival Road, Smithfield, NSW 2164, Australia.

C Corresponding authors. Email: jason.smith@utas.edu.au; alex.bissember@utas.edu.au

Australian Journal of Chemistry 71(9) 702-707 https://doi.org/10.1071/CH18265
Submitted: 1 June 2018  Accepted: 2 July 2018   Published: 26 July 2018

Abstract

Studies of the phytochemistry of carob (Ceratonia siliqua) leaf material are extremely limited. This report features the second natural product isolation study of carob leaves and the first such investigation of C. siliqua grown in Australia. Investigation of leaf material from seven carob cultivars using pressurised hot water extraction (PHWE) revealed the presence of high levels of myricitrin, d-pinitol, and sucrose in addition to the previously unreported natural product siliquapyranone {(2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-2-(((2S,4S)-2-methyl-6-oxotetrahydro-2H-pyran-4-yl)oxy)tetrahydro-2H-pyran-3,4-diyl bis(3,4,5-trihydroxybenzoate)}. Siliquapyranone represents a biosynthetic fusion of conventional 2,3-gallate esters on a β-glucose tannin with a hydroxytetrahydro-2H-pyran-2-one-related non-tannin tetrahydropyran-2-one, parasorboside. Preliminary biological testing indicates that siliquapyranone exhibits weak activity against both tumour and normal cell lines. This suggests that, like most tannins and parasorboside, siliquapyranone may act as an antifeedant.


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