Rapid Microwave-Assisted Synthesis of N-Aryl 1,2,3,4-Tetrahydroisoquinolines
José Augusto Forni A , Martin Brzozowski A , John Tsanaktsidis A , G. Paul. Savage A and Anastasios Polyzos A B C
+ Author Affiliations
- Author Affiliations
A CSIRO Manufacturing Flagship, Private Bag 10, Clayton South, Vic. 3169, Australia.
B School of Chemistry, The University of Melbourne, Parkville, Vic. 3010, Australia.
C Corresponding author. Email: tash.polyzos@csiro.au
Australian Journal of Chemistry 68(12) 1890-1893 https://doi.org/10.1071/CH15490
Submitted: 11 August 2015 Accepted: 7 October 2015 Published: 28 October 2015
Abstract
N-aryl 1,2,3,4-tetrahydroisoquinolines were prepared rapidly in good yields by the microwave-assisted Pd-catalysed coupling of (hetero)aryl iodides or bromides with 1,2,3,4-tetrahydroisoquinoline. Reactions were typically complete within 5 min for aryl iodides and within 30 min for pyridyl bromides.
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