Host–Guest Inclusion System of Luteolin with Polyamine-β-cyclodextrin: Preparation, Characterisation, Anti-oxidant and Anti-cancer Activity
Manshuo Liu A , Rongqiang Liao A , Yulin Zhao B and Bo Yang A C
+ Author Affiliations
- Author Affiliations
A Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
B Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, China.
C Corresponding author. Email: yangb_2015@163.com
Australian Journal of Chemistry 69(2) 174-182 https://doi.org/10.1071/CH15194
Submitted: 16 April 2015 Accepted: 30 June 2015 Published: 7 August 2015
Abstract
The characterisation, inclusion complexation behaviours, and binding ability of inclusion complexes of luteolin (LU) with four polyamine-modified β-cyclodextrins (NH2-βCD, EN-βCD, DETA-βCD, TETA-βCD; where EN = ethylenediamine; DETA = diethylenediamine; TETA = triethylenetetramine) were investigated in both the solid and solution forms by photoluminescence spectroscopy, 1H and 2D NMR spectroscopy, differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy. The results showed that the water solubility, and the anti-oxidant activity and anti-cancer activity of LU were significantly increased in the inclusion complex with polyamine-β-cyclodextrin. The LU/CDs complex will be useful for its application as herbal medicine or healthcare product.
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