Evidence for Why Tri(ethylene oxide) Functionalized Si–C Linked Monolayers on Si(111) Have Inferior Protein Antifouling Properties Relative to the Equivalent Alkanethiol Monolayers Assembled on Gold

Till Böcking; Michael Gal; Katharina Gaus; J. Justin Gooding

doi:10.1071/CH05121

RESEARCH ARTICLE

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Evidence for Why Tri(ethylene oxide) Functionalized Si–C Linked Monolayers on Si(111) Have Inferior Protein Antifouling Properties Relative to the Equivalent Alkanethiol Monolayers Assembled on Gold

Till Böcking ^A ^B , Michael Gal ^B , Katharina Gaus ^C and J. Justin Gooding ^A ^D

+ Author Affiliations

- Author Affiliations

^A School of Chemistry, University of New South Wales, Sydney NSW 2052, Australia.

^B School of Physics, University of New South Wales, Sydney NSW 2052, Australia.

^C Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia.

^D Corresponding author. Email: Justin.Gooding@unsw.edu.au

Australian Journal of Chemistry 58(9) 660-663 https://doi.org/10.1071/CH05121
Submitted: 16 May 2005 Accepted: 19 July 2005 Published: 21 September 2005

Abstract

High quality methoxy-terminated monolayers containing a tri(ethylene oxide) moiety were formed on Si(111)–H surfaces in thermal hydrosilylation reactions. X-ray photoelectron spectroscopy, contact angle, and X-ray reflectivity measurements suggested that the suboptimal protein anti-fouling properties of these Si–C linked monolayers were due to a reduced lateral packing density of the chains resulting in a disordered layer with insufficient internal and external hydrophilicity.

Acknowledgments

This work was supported by the Australian Research Council and the Australian Institute for Nuclear Science and Engineering. The authors thank Dr Jeremy Ruggles for help with X-ray reflectometry.

References

^* The detection of oxygen is more sensitive than that of silicon in XPS. Thus, oxide can be detected more readily in the oxygen 1s region than in the silicon 2p region. The level of oxide detected here was considered to be insignificant. Even samples prepared from non-functionalized alkenes often reveal similar levels of surface oxidation.

Evidence for Why Tri(ethylene oxide) Functionalized Si–C Linked Monolayers on Si(111) Have Inferior Protein Antifouling Properties Relative to the Equivalent Alkanethiol Monolayers Assembled on Gold

Abstract

Acknowledgments

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