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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Reactivities of Piperazine-2,5-diones in Radical Bromination Reactions

CLL Chai, DCR Hockless and AR King

Australian Journal of Chemistry 49(11) 1229 - 1233
Published: 1996

Abstract

The reactivities of various N,N'- diacetylated piperazine-2,5-diones towards radical bromination reactions are reported. The studies show that glycyl centres of piperazine-2,5-diones are more reactive towards radical bromination reactions compared to α-substituted amino acid centres. In addition, large differences in reactivities were observed for the cis and trans isomers of N,N'-diacetylated alanine anhydride. Single-crystal structure determination of each isomer revealed that conformational effects may account for the difference in chemical reactivity.

https://doi.org/10.1071/CH9961229

© CSIRO 1996

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