Synthesis of Casein-Related Peptides and Phosphopeptides. XII. The Synthesis of O-Phosphoseryl-Containing Peptides With Site-Specific Serine Residues
JW Perich and RB Johns
Australian Journal of Chemistry
44(3) 405 - 409
Published: 1991
Abstract
The synthesis of the two Ser/Ser(P)-containing peptides H-Ser-Ser(P)-Ser(P)-NHMe.CF3CO2H and H-Ser(P)-Ser-Ser(P)-NHMe.CF3CO2H is described. The selective use of Boc-Ser(PO3Ph2)-OH and Boc -Ser( Bzl )-OH in the Boc mode of peptide synthesis for the preparation of the protected Ser( Bzl )/Ser(PO3Ph2)-containing peptides is followed by platinum-mediated hydrogenolytic cleavage of the benzyl ether and phenyl phosphate groups.
https://doi.org/10.1071/CH9910405
© CSIRO 1991