Two New Bromotyrosine-Derived Metabolites From an Australian Marine Sponge, Aplysina sp

Abstract

Two new bromotyrosine-derived secondary metabolites, aplysamine-1 (5) and aplysamine-2 (6), were isolated from an Australian marine sponge, Aplysina sp. The structures were assigned on the basis of detailed spectroscopic analysis, and the tertiary amine salt character was revealed by conversion into the corresponding free tertiary amines. Cooccurring with (5) and (6) were the known antibiotic compounds (+)-aeroplysinin (1) and (3′,5′-dibromo-4′-ethoxy-1′-hydroxy-4′-methoxycyclohexa-2′,5′-dienyl)acetamide (2).