(+)-Iforrestine: a Novel Heterocyclic Nephrotoxin From Isotropis forrestii

Abstract

A compound that reproduces the acute renal proximal tubular necrosis associated with ingestion of Isotropis forrestii, by animals, has been isolated from the plant. The novel heterocyclic structure was determined by a single-crystal X-ray diffraction study. The spectroscopic data are presented and rationalized with respect to the assigned structure.