Preparation of (S)-3-Azidodihydrofuran-2(3H)-one(α-Azidobutyrolactone) (1), a Useful Chiral Synthon

Abstract

(S)-3-Azidodihydrofuran-2(3H)-one (α- Azidobutyrolactone ) (1) has been resolved through the brucine salt of the corresponding hydroxy acid (2). Both (1), and various derivatives of (2), are useful synthons for the preparation of L-amino acids related to L- homoserine.