Thermodynamic Analysis of Tyrosyl-tRNA Synthetases Revealed Bacterial-Selective Tyrosine Derivatives
Zhongqiang Wang
A B C D , Hayden Matthews C D , Guozhong Deng A B , Xiaojian Zhou A B and Yongzheng Chen A B
+ Author Affiliations
- Author Affiliations
A Key Laboratory of Biocatalysis and Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China.
B Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, 563000, China.
C Research School of Chemistry, Australian National University, 137 Sullivans Creek Road, Acton, ACT 2601, Australia.
D Corresponding authors. Emails: zqwang_go@zmu.edu.cn; Hayden.Matthews@anu.edu.au
Australian Journal of Chemistry 74(10) 740-745 https://doi.org/10.1071/CH21218
Submitted: 1 September 2021 Accepted: 5 October 2021 Published: 2 November 2021
Abstract
The non-proteinogenic amino acids m-fluorotyrosine and 2,4-dihydroxyphenylalanine demonstrated a respective 6- and 12-fold greater binding affinity to the purified tyrosyl-tRNA synthetase from Escherichia coli than that from human cytosol. The differential binding was identified by probing the substrate selectivity of the two enzymes with structural analogues of tyrosine using a thermodynamic technique.
Keywords: tyrosyl-tRNA synthetase, enzyme selectivity, amino acids, species selectivity.
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