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RESEARCH ARTICLE
Contents Vol 73(12)

Bismuth(iii) Thiophosphinates: Understanding How a Small Atomic Change Influences Antibacterial Activity and Mammalian Cell Viability*

Dimuthu C. Senevirathna A , Rebekah N. Duffin A B , Liam J. Stephens A , Megan E. Herdman A , Melissa V. Werrett https://orcid.org/0000-0001-6811-4504 A C and Philip C. Andrews A C
+ Author Affiliations
- Author Affiliations

A School of Chemistry, Monash University, Clayton, Vic. 3800, Australia.

B Current address: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Parkville, Vic. 3052, Australia.

C Corresponding authors. Email: melissa.werrett@monash.edu; phil.andrews@monash.edu

Australian Journal of Chemistry 73(12) 1226-1236 https://doi.org/10.1071/CH20169
Submitted: 28 May 2020  Accepted: 3 August 2020   Published: 18 September 2020

Abstract

Diphenylphosphinothioic acid (HSP(=O)Ph2) and diphenylphosphinodithioic acid (HSP(=S)Ph2) have been used to synthesise four BiIII complexes: 1 [Bi(SP(=O)Ph2)3], 2 [BiPh(SP(=O)Ph2)2], 3 [BiPh2(SP(=O)Ph2)], and 4 [Bi(SP(=S)Ph2)3], using BiPh3 and [Bi(OtBu)3] as bismuth sources. The complexes have been characterised by NMR spectroscopy, mass spectrometry, infrared spectroscopy, powder X-ray diffraction, and singe crystal X-ray crystallography (2–4). Biological studies indicated that despite complexes 2 and 3 reducing mammalian cell viability, their antibacterial activity provides a good degree of selectivity towards both Gram positive and Gram negative bacterial strains. The minimum inhibitory concentrations for complexes 2 and 3 are in the range of 0.52–5.5 µM towards the bacteria tested. Homoleptic complexes 1 and 4 were generally less active towards both bacterial and mammalian cells.


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