Effect of Structured Surfaces on MALDI Analyte Peak Intensities*
Sajid Bashir A B E , Jingbo L. Liu B and Peter J. Derrick A C D
+ Author Affiliations
- Author Affiliations
A Institute of Mass Spectrometry, University of Warwick, Coventry, CV4 7AL, UK.
B Texas A&M University – Kingsville, Department of Chemistry, MSC 161, 700 University Boulevard, Kingsville, TX 78363, USA.
C Department of Physics, The University of Auckland, 7 Symonds Street, Auckland 1061, New Zealand.
D Deceased.
E Corresponding author. Email: br9@hotmail.com
Australian Journal of Chemistry 70(12) 1312-1316 https://doi.org/10.1071/CH17456
Submitted: 8 August 2017 Accepted: 5 September 2017 Published: 6 October 2017
Abstract
A surface modification method is presented: a sodium chloride crystal, a transparent wide bandgap insulator, was deposited onto a stainless steel surface. The surface was subjected to various stimuli to induce surface defects either on the steel surface or salt crystal and the ion yield of substance P, a model peptide, was investigated as a function of stimuli. The interaction of the laser at potential defect sites resulted in an increase in the ion yield of substance P (3–17 fold increase relative to no stimuli).
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