EBC-316, 325–327, and 345: New Pimarane Diterpenes from Croton insularis Found in the Australian Rainforest
Lidia A. Maslovskaya A , Andrei I. Savchenko B , Victoria A. Gordon C , Paul W. Reddell C , Carly J. Pierce A , Peter G. Parsons A and Craig M. Williams B D
+ Author Affiliations
- Author Affiliations
A QIMR Berghofer Medical Research Institute, PO Royal Brisbane Hospital, Brisbane, Qld 4029, Australia.
B School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Qld 4072, Australia.
C EcoBiotics Limited, PO Box 1, Yungaburra, Qld 4884, Australia.
D Corresponding author. Email: c.williams3@uq.edu.au
Australian Journal of Chemistry 68(4) 652-659 https://doi.org/10.1071/CH14550
Submitted: 8 September 2014 Accepted: 5 November 2014 Published: 13 January 2015
Abstract
Five new pimarane and related-type diterpenes (i.e. EBC-316, 325–327, and 345 (10–15)), together with two known pimaranes (EBC-221 (8) and EBC-346 (9)), were isolated from the stems of Croton insularis, found in the Australian rainforest. All pimarane diterpenes disclosed herein are suggested to be biogenetically related to the same keto-Jacobs–Reynolds intermediate 2, via ring A and C oxidation. Anticancer activities of compounds 11–13 are reported.
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