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RESEARCH ARTICLE
Contents Vol 67(1)

Understanding the Diffusion of Dextrans in ‘Click’ PNIPAAm Hydrogels

Huey Wen Ooi A , Hui Peng A , Kevin S. Jack B and Andrew K. Whittaker A C D
+ Author Affiliations
- Author Affiliations

A Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Qld 4072, Australia.

B Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Qld 4072, Australia.

C Centre for Advanced Imaging, The University of Queensland, Brisbane, Qld 4072, Australia.

D Corresponding author. Email: a.whittaker@uq.edu.au




Professor Andrew Whittaker leads the Polymer Chemistry group within the Australian Institute for Bioengineering and Nanotechnology, and the Centre for Advanced Imaging at the University of Queensland. He received his Ph.D. from the UQ in 1986, and subsequently held positions as a Research Fellow at the USTL, Montpellier, at the MPIP, Mainz, followed by a position as research chemist at BP Research Sunbury for three years. He rejoined UQ in 1991 and was promoted to full professor in 2004. His research interests span many aspects of polymer physical chemistry. The target application areas are polymeric biomaterials and polymers for photolithography.

Australian Journal of Chemistry 67(1) 85-92 https://doi.org/10.1071/CH13333
Submitted: 28 June 2013  Accepted: 1 September 2013   Published: 8 October 2013

Abstract

Arguably the most important property of a hydrogel is the ability to allow the diffusion of solutes through the crosslinked network. Studies of the diffusion in hydrogels are important for providing information on the rate and extent of the passage of the solute and on the details of the microstructure of the hydrogel. Such knowledge is directly relevant for applications such as controlled drug delivery systems. The structure of novel poly(N-isopropylacrylamide) (PNIPAAm) hydrogels can be revealed by the restricted diffusion of appropriate probe molecules. Dextran molecules, labelled with fluorescent moieties, were incorporated into well-defined PNIPAAm hydrogels to investigate the effects of hydrogel mesh size and dextran molecular size on the diffusivities of solute molecules.


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