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RESEARCH ARTICLE
Contents Vol 66(8)

Release Kinetics of 6-Mercaptopurine and 6-Thioguanine from Bioinspired Core-Crosslinked Thymine Functionalised Polymeric Micelles

Gagan Kaur A , Milton T. W. Hearn A , Toby D. M. Bell A and Kei Saito A B
+ Author Affiliations
- Author Affiliations

A School of Chemistry, Monash University, Clayton, Vic. 3800, Australia.

B Corresponding author. Email: kei.saito@monash.edu

Australian Journal of Chemistry 66(8) 952-958 https://doi.org/10.1071/CH13125
Submitted: 19 March 2013  Accepted: 30 April 2013   Published: 22 May 2013

Abstract

A bioinspired core-bound polymeric micellar system based on hydrogen bonding and photo-crosslinking of thymine has been prepared from the amphiphilic block copolymers, poly(vinylbenzylthymine)-block-poly(vinylbenzyltriethylammonium chloride). The chemical loading and controlled release potential of these micelles was investigated using two drugs, 6-mercaptopurine and 6-thioguanine. The release kinetics of drug-loaded polymeric micelles was determined by pressure ultrafiltration and the effects of hydrogen bonding, core-crosslinking, and core size on the loading capacity and release kinetics were analysed. The results demonstrate that drug release rates are affected by hydrogen bonding in the micelle core. Furthermore, these studies indicate that drug release rates can be controlled by changing the size of the core and by photo-crosslinking thymine groups in the core.


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