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Contents Vol 62(7)

Recent Advances in the Total Synthesis of Polyketide Natural Products as Promising Anticancer Agents

Ian Paterson A B and Alison D. Findlay A
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A University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.

B Corresponding author. Email: ip100@cam.ac.uk

Australian Journal of Chemistry 62(7) 624-638 https://doi.org/10.1071/CH09104
Submitted: 21 February 2009  Published: 13 July 2009

Abstract

A growing number of complex polyketides, isolated from a variety of marine and terrestrial sources, present novel scaffolds for the development of cancer therapeutic agents. However, the low natural abundance of such lead compounds often precludes full biological evaluation, which demands the development of efficient synthetic routes to afford a sustainable supply. In this account, we provide an overview of the total synthesis of several representative anticancer polyketides – dolastatin 19, spirangien A, reidispongiolide A, and spongistatin 1/altohyrtin A – based on versatile aldol methodology developed in our group.


Acknowledgements

It is a pleasure to thank my able and enthusiastic co-workers, whose work is described in this account and who are cited by name in the accompanying references. The EPSRC and Merck Research Laboratories are thanked for support, and Professor G. R. Pettit (Arizona State University) and Professor M. V. D’Auria (University of Naples ‘Federico II’) for many helpful discussions.


References


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