Polydimethylsiloxane-Based Polyurethanes: Phase-Separated Morphology and In Vitro Oxidative Biostability

Taeyi Choi; Jadwiga Weksler; Ajay Padsalgikar; Rebeca Hernández; James Runt

doi:10.1071/CH09096

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Polydimethylsiloxane-Based Polyurethanes: Phase-Separated Morphology and In Vitro Oxidative Biostability

Taeyi Choi ^A , Jadwiga Weksler ^B , Ajay Padsalgikar ^B , Rebeca Hernández ^C and James Runt ^A ^D

+ Author Affiliations

- Author Affiliations

^A Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA.

^B AorTech Biomaterials, Dalmore Drive, Caribbean Park, Scoresby, Vic. 3179, Australia.

^C Instituto de Ciencia y Tecnología de Polímeros, Consejo Superior de Investigaciones Cientificas, Juan de la Cierva, 328006 Madrid, Spain.

^D Corresponding author. Email: runt@matse.psu.edu

Australian Journal of Chemistry 62(8) 794-798 https://doi.org/10.1071/CH09096
Submitted: 15 February 2009 Accepted: 11 June 2009 Published: 13 August 2009

Abstract

Three series of segmented polyurethane block copolymers were synthesized using 4,4′-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BDO) or 1,3-bis(4-hydroxybutyl)tetramethyl disiloxane (BHTD) as the hard segments, and soft segments composed of poly(dimethyl siloxane) (PDMS)-based and poly(hexamethylene oxide) (PHMO) macrodiols. Copolymers synthesized with the PDMS macrodiol and PDMS and PHMO macrodiol mixtures consist of three microphases: a PDMS phase, hard domains, and a mixed phase of PHMO (when present), PDMS ether end-group segments and some dissolved hard segments. Degrees of phase separation were characterized using small-angle X-ray scattering by applying a pseudo two-phase model, and the morphology resulting from unlike segment demixing was found to be closely related to the in vitro oxidative biostability of these segmented polyurethanes.

References

Polydimethylsiloxane-Based Polyurethanes: Phase-Separated Morphology and In Vitro Oxidative Biostability

Abstract

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