Syntheses of the Seco Benzyltetrahydroisoquinoline Alkaloids Polysignine and Methoxypolysignine

Abstract

The structures previously assigned to the seco benzyltetrahydroisoquinoline alkaloids polysignine (1) and methoxypolysignine (2) have been confirmed by total syntheses in which the key step involved cleavage of the C1–N bonds in the corresponding N-methylbenzyltetrahydroisoquinolines.