Capturing benefits from the bovine genome sequence
Ross L. TellamCSIRO Livestock Industries, Queensland Biosciences Precinct, 306 Carmody Road, St Lucia, Qld 4067, Australia. Email: Ross.Tellam@csiro.au
Australian Journal of Experimental Agriculture 47(9) 1039-1050 https://doi.org/10.1071/EA06032
Submitted: 10 January 2006 Accepted: 6 September 2006 Published: 6 August 2007
Abstract
The bovine genome sequence in ‘draft’ form will be complete in 2007. The availability of the sequence and very large numbers of single nucleotide polymorphisms will have profound effects on livestock production. The dairy industry is well positioned to capture the benefits of this enormous and enabling resource because of its comprehensive databases containing phenotypic and pedigree data for large numbers of animals, intense utilisation of genetics in breeding programs and efficient management of reproductive performance. The bovine genome sequence will assist in the development of novel products, especially value-added products, and markedly enhance the rate of genetic gain in the Australian dairy population. The immediate challenge facing the industry is the integration of new technological capabilities into existing breeding programs and production systems.
Additional keywords: cow, ruminant.
Acknowledgements
I thank a long list of colleagues, particularly members of the BGSP and its advisory groups for stimulating thought and their enormous breadth of knowledge.
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1 ‘Finished’ sequence is defined as ‘the clone insert is contiguously sequenced with high quality standard error rate of 0.01% – there are usually no gaps in the sequence’. A ‘draft’ sequence can have different definitions depending on the specific project but a typical definition is: ‘at least 3–4× of the estimated clone insert is covered in Phred Q20 bases in the whole genome shotgun stage. Clone sequence may contain several pieces of sequence, separated by gaps. The true order and orientation of these pieces may not be known.’ (National Centre for Biotechnology Information, Bethesda, MD).
