Recent findings regarding calcium and phytase in poultry nutrition
M. Bedford A B and X. Rousseau A
+ Author Affiliations
- Author Affiliations
A AB Vista, Marlborough, Wiltshire, SN8 4AN, UK.
B Corresponding author. Email: Mike.Bedford@abvista.com
Animal Production Science 57(11) 2311-2316 https://doi.org/10.1071/AN17349
Submitted: 26 May 2017 Accepted: 5 July 2017 Published: 21 July 2017
Abstract
Calcium (Ca) is an essential element for poultry and even a mild deficiency can lead to significant welfare and performance issues. As a result, it is often fed at levels in excess of requirement, partly as an insurance policy and, to some degree, because of its relatively low cost compared with other feed ingredients. However, when diets meet but do not exceed the phosphorus (P) requirements of the bird, a marginal Ca excess can interfere with P digestibility. This problem is exacerbated when phytases are used to provide some of the required P because Ca decreases the efficiency of phytate (IP6) hydrolysis in a dose-dependent manner. More recently, phytases have been used at very high doses (1500 FyTase units (FTU); ‘superdosing’) in commercial diets, to improve bird performance by removing as much of the dietary IP6 and lower esters of phytate (IP5, IP4, IP3 and IP2) as possible, all of which are considered anti-nutrients, and concomitantly producing as much inositol, a nutrient, as possible. In such a regimen, the ability of the phytase to degrade the lower phytate esters, namely IP4, IP3 and IP2, takes on greater importance than does simply releasing phytate P. Calcium has recently been shown to reduce the efficacy of hydrolysis of the lower phytate esters to a greater degree than the extent to which it decreases IP6 hydrolysis. As a result, Ca concentrations in the diet should be monitored frequently if the maximum value of a phytase is to be realised.
Additional keywords: broiler, pH, phosphorus.
References
Amerah AM, Plumstead PW, Barnard LP, Kumar A (2014) Effect of calcium level and phytase addition on ileal phytate degradation and amino acid digestibility of broilers fed corn-based diets. Poultry Science 93, 906–915.| Effect of calcium level and phytase addition on ileal phytate degradation and amino acid digestibility of broilers fed corn-based diets.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC2cnht1Wlsw%3D%3D&md5=717313f9ff960138f566d3763f6f6c73CAS |
Bedford MR, Parr T, Persia ME, Batal AB, Wyatt CL (2007) Influence of dietary calcium and phytase source on litter moisture and mineral content. Poultry Science Abstracts 86, 673
Beeson L, Walk CL, Bedford MR, Olukosi OA (2017) Hydrolysis of phytate to its lower esters can influence the growth performance nutrient utilization of broilers with regular or superdoses of phytase. Poultry Science
| Hydrolysis of phytate to its lower esters can influence the growth performance nutrient utilization of broilers with regular or superdoses of phytase.Crossref | GoogleScholarGoogle Scholar |
Bradbury EJ, Wilkinson SJ, Cronin GM, Thomson P, Walk CL, Cowieson AJ (2016) Evaluation of the effect of a highly soluble calcium source in broiler diets supplemented with phytase on performance, nutrient digestibility, foot ash, mobility and leg weakness. Animal Production Science.
| Evaluation of the effect of a highly soluble calcium source in broiler diets supplemented with phytase on performance, nutrient digestibility, foot ash, mobility and leg weakness.Crossref | GoogleScholarGoogle Scholar |
Cowieson AJ, Acamovic T, Bedford MR (2004) The effects of phytase and phytic acid on the loss of endogenous amino acids and minerals from broiler chickens. British Poultry Science 45, 101–108.
| The effects of phytase and phytic acid on the loss of endogenous amino acids and minerals from broiler chickens.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhs1Wgu7c%3D&md5=1f0e209134af982f358fc085303804f5CAS |
Cowieson AJ, Wilcock P, Bedford MR (2011) Superdosing effects of phytase in poultry and other monogastrics. World’s Poultry Science Journal 67, 225–235.
| Superdosing effects of phytase in poultry and other monogastrics.Crossref | GoogleScholarGoogle Scholar |
Evans WJ, McCourtney EJ, Shrager RI (1982) Titration studies of phytic acid. Journal of the American Oil Chemists’ Society 59, 189–191.
| Titration studies of phytic acid.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL38XhvFyjsLk%3D&md5=f70d26b04b8cff69926af53679cb8368CAS |
Gao CQ, Ji C, Zhao LH, Zhang JY, Ma QG (2013) Phytase transgenic corn in nutrition of laying hens: residual activity and phytate phosphorus content in the gastrointestinal tract. Poultry Science 92, 2923–2929.
| Phytase transgenic corn in nutrition of laying hens: residual activity and phytate phosphorus content in the gastrointestinal tract.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXhslymtrrI&md5=7f0a4b6a679a5e46c6cf087dc73a21feCAS |
González-Vega JC, Walk CL, Liu Y, Stein HH (2014) The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility. Archives of Animal Nutrition 68, 126–142.
| The site of net absorption of Ca from the intestinal tract of growing pigs and effect of phytic acid, Ca level and Ca source on Ca digestibility.Crossref | GoogleScholarGoogle Scholar |
Lee SA, Dunne J, Mottram T, Bedford MR (2017) Effect of diet phase change, dietary Ca and P level and phytase on bird performance and real-time gizzard pH measurements. British Poultry Science
| Effect of diet phase change, dietary Ca and P level and phytase on bird performance and real-time gizzard pH measurements.Crossref | GoogleScholarGoogle Scholar |
Li W, Angel R, Kim SW, Brady K, Yu S, Plumstead PW (2016) Impacts of dietary calcium, phytate, and nonphytate phosphorus concentrations in the presence or absence of phytase on inositol hexakisphosphate (IP6) degradation in different segments of broilers digestive tract. Poultry Science 95, 581–589.
| Impacts of dietary calcium, phytate, and nonphytate phosphorus concentrations in the presence or absence of phytase on inositol hexakisphosphate (IP6) degradation in different segments of broilers digestive tract.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC28rnslejtg%3D%3D&md5=6eadfa0c786fa0b99c29fa5920de2cedCAS |
Liu N, Cowieson AJ (2011) Effect of Phytic acid and pH value on the activation of chicken pepsinogen in vitro. Australian Poultry Science Symposium 22, 84–87.
Liu SY, Bold RM, Plumstead PW, Selle PH (2015) Effects of 500 and 1000 FTU/kg phytase supplementation of maize-based diets with two tiers of nutrient specifications on performance of broiler chickens. Animal Feed Science and Technology 207, 159–167.
| Effects of 500 and 1000 FTU/kg phytase supplementation of maize-based diets with two tiers of nutrient specifications on performance of broiler chickens.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXhtVegs77O&md5=ab7bd672ebb2411669fdec6fce93a830CAS |
Lonnerdal B (2002) Phytic acid-trace element (Zn, Cu, Mn) interaction. International Journal of Food Science & Technology 37, 749–758.
| Phytic acid-trace element (Zn, Cu, Mn) interaction.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XotFygtLs%3D&md5=c880bbfc2fe5fbd06451f96bda0abf37CAS |
Lowe JT, Steenbock H (1936) Cereals and rickets. VIII. The hydrolysis of phytin in the intestine. The Biochemical Journal 30, 1991–1995.
| Cereals and rickets. VIII. The hydrolysis of phytin in the intestine.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaA2sXhtlCisw%3D%3D&md5=ad823a6ceaee9eb91e6d1b5ff3db1336CAS |
Maenz DD, Engele-Schaan CM, Newkirk RW, Classen HL (1999) The effect of minerals and mineral chelators on the formation of phytase-resistant and phytase-susceptible forms of phytic acid in solution and in a slurry of canola meal. Animal Feed Science and Technology 81, 177–192.
| The effect of minerals and mineral chelators on the formation of phytase-resistant and phytase-susceptible forms of phytic acid in solution and in a slurry of canola meal.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXmsVWmur4%3D&md5=5074147a0ab5288c007859e75b006d77CAS |
Menezes-Blackburn D, Gabler S, Greiner R (2015) Performance of seven commercial phytases in an in vitro simulation of poultry digestive tract. Journal of Agricultural and Food Chemistry 63, 6142–6149.
| Performance of seven commercial phytases in an in vitro simulation of poultry digestive tract.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXhtVOit73I&md5=7384a5784dc5a94b523decf6b6c1b56aCAS |
Morgan NK, Walk CL, Bedford MR, Burton EJ (2014) The effect of dietary calcium inclusion on broiler gastrointestinal pH: quantification and method optimization. Poultry Science 93, 354–363.
| The effect of dietary calcium inclusion on broiler gastrointestinal pH: quantification and method optimization.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXitFWisLY%3D&md5=960f1ae0f2069ac52542d67436d1e4c8CAS |
Onyango EM, Asem EK, Adeola O (2009) Phytic acid increases mucin and endogenous amino acid losses from the gastrointestinal tract of chickens. British Journal of Nutrition 101, 836–842.
| Phytic acid increases mucin and endogenous amino acid losses from the gastrointestinal tract of chickens.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXktleisr8%3D&md5=6e7f13f9e831c12071e9729923a7ae85CAS |
Pirgozliev V, Bedford MR, Rose SP (2014) Interaction between supplementary myo-inositol and phytase in poultry diets: effect on dietary phosphorus digestibility. British Poultry Abstracts 10, 14–15.
Rousseau X, Meme N, Magnin M, Nys Y, Narcy A (2011) Meta-analyse de l’utilisation de phosphore alimentaire par le poulet de chair en phase de finition; effet de l’apport de calcium et de phytase microbienne. Journees de la Recherché Avicole 9, 265–269.
Rousseau X, Valable A-S, Letourneau-Montminy MP, Meme N, Godet E, Magnin M, Nys Y, Duclos MJ, Narcy A (2016) Adaptive response of broilers to dietary phosphorus an calcium restrictions. Poultry Science 95, 2849–2860.
| Adaptive response of broilers to dietary phosphorus an calcium restrictions.Crossref | GoogleScholarGoogle Scholar |
Sommerfeld V, Schollenberger M, Hemberle L, Rodehutscord M (2017) Modification and application of an in vitro assay to examine inositol phosphate degradation in the digestive tract of poultry. Journal of the Science of Food and Agriculture
| Modification and application of an in vitro assay to examine inositol phosphate degradation in the digestive tract of poultry.Crossref | GoogleScholarGoogle Scholar |
Walk CL (2016) The influence of calcium on phytase efficacy in non-ruminant animals. Animal Production Science 56, 1345–1349.
| The influence of calcium on phytase efficacy in non-ruminant animals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC28XhtVCltLvP&md5=3c5891f5267e2d6bc4faebb5d4bd786bCAS |
Walk CL, Bedford MR, McElroy AP (2012) Influence of limestone and phytase on broiler performance, gastrointestinal pH and apparent ileal nutrient digestibility. Poultry Science 91, 1371–1378.
| Influence of limestone and phytase on broiler performance, gastrointestinal pH and apparent ileal nutrient digestibility.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XpsVKis7g%3D&md5=f68bbed87a5a671b0ce6c9b79e00412dCAS |
Walk CL, Santos TT, Bedford MR (2014) Influence of superdoses of a novel microbial phytase on growth performance, tibia ash, and gizzard phytate and inositol in young broilers. Poultry Science 93, 1172–1177.
| Influence of superdoses of a novel microbial phytase on growth performance, tibia ash, and gizzard phytate and inositol in young broilers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXosFCns70%3D&md5=cef160691200979587cdc809e8851a3cCAS |
Woyengo TA, Adeola O, Udenigwe CC, Nyachoti CM (2010) Gastro-intestinal digesta pH, pepsin activity and soluble mineral concentration responses to supplemental phytic acid and phytase in piglets. Livestock Science 134, 91–93.
| Gastro-intestinal digesta pH, pepsin activity and soluble mineral concentration responses to supplemental phytic acid and phytase in piglets.Crossref | GoogleScholarGoogle Scholar |
Yu S, Cowieson AJ, Gilbert C, Plumstead PW, Dalsgaard S (2012) Interactions of phytate and myo-inositol phosphate esters (IP1–5) including IP5 isomers with dietary protein and iron and inhibition of pepsin. Journal of Animal Science 90, 1824–1832.
| Interactions of phytate and myo-inositol phosphate esters (IP1–5) including IP5 isomers with dietary protein and iron and inhibition of pepsin.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XpsFWgsbw%3D&md5=c0388c2933c989b2f2e8fe5bd3b856abCAS |
Zeller E, Schollenberger M, Kuhn I, Rodehutscord M (2015a) Effect of diets containing enzyme supplements and microwave-treated or untreated wheat on inositol phosphates in the small intestine of broilers. Animal Feed Science and Technology 204, 42–51.
| Effect of diets containing enzyme supplements and microwave-treated or untreated wheat on inositol phosphates in the small intestine of broilers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXlsVOrtL8%3D&md5=f32a2ce963ffc4061549f5c65917bb71CAS |
Zeller E, Schollenberger M, Witzig M, Shastak Y, Kuhn I, Hoelzle E, Rodehutscord M (2015b) Interactions between supplemented mineral phosphorus and phytase on phytate hydrolysis and inositol phosphates in the small intestine of broilers. Poultry Science 94, 1018–1029.
| Interactions between supplemented mineral phosphorus and phytase on phytate hydrolysis and inositol phosphates in the small intestine of broilers.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC28XhvFektrzN&md5=43394c339d374695d11754e250a23fb5CAS |
Zhang B, Coon CN (1997) Improved in vitro methods for determining limestone and oyster shell solubility. Journal of Applied Poultry Research 6, 94–99.
| Improved in vitro methods for determining limestone and oyster shell solubility.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXisleiuro%3D&md5=93c4e07fb92deaecb7cf75de0ba32153CAS |
Zyla K, Mika M, Stodolak B, Wikiera A, Koreleski J, Swiatkiewicz S (2004) Towards complete dephosphorylation and total conversion of phytates in poultry feeds. Poultry Science 83, 1175–1186.
| Towards complete dephosphorylation and total conversion of phytates in poultry feeds.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXmt1Okt7c%3D&md5=13d79199f033bc1b4d58a7a241c1337bCAS |
