Immunisation against gonadotrophin-releasing hormone (GnRH) reduces agonistic behaviours in male rangeland goats
Catherine C. Bishop A , Patricia A. Fleming A , Anne L. Barnes A , Teresa Collins A and David W. Miller A BA School of Veterinary and Life Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia.
B Corresponding author. Email: D.Miller@murdoch.edu.au
Animal Production Science 56(11) 1882-1887 https://doi.org/10.1071/AN15076
Submitted: 10 February 2015 Accepted: 31 May 2015 Published: 27 July 2015
Abstract
Rangeland goat bucks were used to evaluate the efficacy of a commercially available anti-gonadotrophin-releasing hormone vaccine, Improvac (Zoetis Australia, West Ryde, NSW, Australia). The hypothesis tested was that immunisation would suppress testosterone secretion by the testis and agonistic behaviour between male goats. We also compared intervals of 2 and 4 weeks between primary and booster immunisations and monitored responses over a 2-month period. The 45 goats were split into three groups (n = 15): one group receiving the vaccination booster on Day 14, one group receiving the vaccination booster on Day 28, and the Control group receiving sterile saline injections. Body mass, body condition score and scrotal circumference were measured fortnightly, and blood was collected at 2-week intervals and analysed for testosterone concentration. Behavioural interaction tests of 2-min duration were also conducted fortnightly. There was a significant decrease in paired testicular circumference (P < 0.05) and testosterone concentration (P < 0.01) in both vaccination groups by the end of the experiment at Day 60, compared with the Control group. Agonistic interactions measured at Day 60 were significantly reduced in both vaccination groups (P < 0.05) compared with the Control group. These results support the efficacy of Improvac in reducing agonistic behaviours in rangeland goat bucks and suggest that the use of the vaccine may assist in reducing social stress and possible injury in groups of confined male goats.
Additional keywords: behaviour, goat, testosterone, vaccine.
References
Albrecht AK, Kanitz E, Puppe B, Traulsen I, Krieter J (2012) Influence of immunisation against GnRF on agonistic and mounting behaviour, serum testosterone concentration and body weight in male pigs compared with boars and barrows. Applied Animal Behaviour Science 138, 28–35.| Influence of immunisation against GnRF on agonistic and mounting behaviour, serum testosterone concentration and body weight in male pigs compared with boars and barrows.Crossref | GoogleScholarGoogle Scholar |
Barroso FG, Alados CL, Boza J (2000) Social hierarchy in the domestic goat: effect on food habits and production. Applied Animal Behaviour Science 69, 35–53.
| Social hierarchy in the domestic goat: effect on food habits and production.Crossref | GoogleScholarGoogle Scholar | 10856783PubMed |
Coblentz BE (1978) The effect of feral goats (Capra hircus) on island ecosystems. Biological Conservation 13, 279–286.
| The effect of feral goats (Capra hircus) on island ecosystems.Crossref | GoogleScholarGoogle Scholar |
Cowley C, Grace P (1988) Bullying a problem in confined goats. Surveillance 15, 30
Delgadillo JA, Cortez ME, Duarte G, Chemineau P, Malpaux B (2004) Evidence that the photoperiod controls the annual changes in testosterone secretion, testicular and body weight in subtropical male goats. Reproduction, Nutrition, Development 44, 183–193.
| Evidence that the photoperiod controls the annual changes in testosterone secretion, testicular and body weight in subtropical male goats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXoslGlsb0%3D&md5=b0e232deda3c96c0a99e7e1ab220c198CAS | 15460158PubMed |
Entwhistle K, Jephcott S (2005) Investigating opportunities to modify the aggressive behaviour of entire male cattle, sheep and goats and the potential impacts on market acceptance and animal productivity, final report of project LIVE.121, pp. 60. Meat & Livestock Australia, North Sydney.
Ewing LL, Wing TY, Cochran RC, Kromann N, Zirkin BR (1983) Effect of luteinizing hormone on Leydig cell structure and testosterone secretion. Endocrinology 112, 1763–1769.
| Effect of luteinizing hormone on Leydig cell structure and testosterone secretion.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3sXhvFais7s%3D&md5=9d9a8d8b3cd237b6652367884535d34eCAS | 6403335PubMed |
Godfrey SI, Walkden-Brown SW, Martin GB, Speijers EJ (1996) Immunisation of goat bucks GnRH to prevent seasonal reproductive and agonistic behaviours. Animal Reproduction Science 44, 41–54.
| Immunisation of goat bucks GnRH to prevent seasonal reproductive and agonistic behaviours.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28XlvVKqt7w%3D&md5=066295f128fe963c12ddee326ed06ed9CAS |
Houpt KA (2011) Aggression and social structure. In Domestic Animal Behaviour for Veterinarians and Animal Scientists. 5th edn. pp. 27–36. (John Wiley & Sons: Ames, IA)
Le Neindre P (1989) Influence of rearing conditions and breed on social behaviour and activity of cattle in novel environments. Applied Animal Behaviour Science 23, 129–140.
| Influence of rearing conditions and breed on social behaviour and activity of cattle in novel environments.Crossref | GoogleScholarGoogle Scholar |
Mitchell TD (1986) ‘Condition scoring goats.’ Agfact A7.2.3. (Agriculture New South Wales: Sydney)
Romeyer A, Bouissou M-F (1992) Assessment of fear reactions in domestic sheep, and influence of breed and rearing conditions. Applied Animal Behaviour Science 34, 93–119.
| Assessment of fear reactions in domestic sheep, and influence of breed and rearing conditions.Crossref | GoogleScholarGoogle Scholar |
Sherwood NM, Lovejoy DA, Coe IR (1993) Origin of mammalian gonadotropin-releasing hormones. Endocrine Reviews 14, 241–254.
Thompson DL (2000) Immunization against GnRH in male species (comparative aspects). Animal Reproduction Science 60–61, 459–469.
| Immunization against GnRH in male species (comparative aspects).Crossref | GoogleScholarGoogle Scholar | 10844216PubMed |
Walkden-Brown SW, Bocquier F (2000) Nutritional regulation of reproduction in goats. International Conference on Goats 7, 389–395.
Walkden-Brown SW, Restall BJ, Norton BW, Scaramuzzi RJ, Martin GB (1994) Effect of nutrition on seasonal patterns of LH, FSH and testosterone concentration, testicular mass, sebaceous gland volume and odour in Australian Cashmere goats. Journal of Reproduction and Fertility 102, 351–360.
| Effect of nutrition on seasonal patterns of LH, FSH and testosterone concentration, testicular mass, sebaceous gland volume and odour in Australian Cashmere goats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXjtFyns78%3D&md5=cc8f30859ad06ad23910f57d854a2d55CAS | 7861388PubMed |
Wu FC, Irby DC, Clarke IJ, Cummins JT, de Kretser DM (1987) Effects of gonadotropin-releasing hormone pulse-frequency modulation on luteinizing hormone, follicle-stimulating hormone and testosterone secretion in hypothalamo/pituitary-disconnected rams. Biology of Reproduction 37, 501–510.
| Effects of gonadotropin-releasing hormone pulse-frequency modulation on luteinizing hormone, follicle-stimulating hormone and testosterone secretion in hypothalamo/pituitary-disconnected rams.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2sXmt12lsLw%3D&md5=e6300f4bda252fcbea607762b4e34ab2CAS | 3118979PubMed |
