Evaluation of the serum fructosamine test to monitor plasma glucose concentration in the late-pregnant sheep
M. L. Sorondo A and A. Cirio B C
+ Author Affiliations
- Author Affiliations
A Departamento de Patología y Clínica de Rumiantes y Suinos, Alberto Lasplaces 1550, Montevideo 11600, Uruguay.
B Departamento de Fisiología, Facultad de Veterinaria, Alberto Lasplaces 1550, Montevideo 11600, Uruguay.
C Corresponding author. Email: albertocirio@yahoo.com
Animal Production Science 51(7) 662-666 https://doi.org/10.1071/AN10244
Submitted: 3 November 2010 Accepted: 16 March 2011 Published: 27 June 2011
Abstract
Since the persistent decrease in blood glucose during late pregnancy in sheep is an index of high risk of metabolic disorder, the present study aimed to evaluate the capacity of the serum fructosamine (Fser) to retrospectively monitor blood glucose. Pregnant grazing sheep were assigned to three treatments: high energy (n = 8), supplemented with 400 g of corn grain from Day 100 until lambing; medium energy (n = 7), not supplemented, and low energy (n = 8), fasted from Days 136 to 141. In weekly blood samples (7 weeks before to 3 weeks after lambing), glucose, fructosamine, β-hydroxybutyrate and total proteins were determined. Serum protein were stable and without differences among groups. β-hydroxybutyrate was higher in the fasted group the week after fasting (P < 0.05). The regression analysis between plasma glucose and Fser in the same week and in the 3 weeks following, showed no significant correlations, actual or retrospective, neither considering all sheep nor within each energy level. The results did not support the usefulness of Fser for monitoring plasma glucose concentration in late pregnant ewes.
References
Aiello SE (Ed.) (1998) ‘The Merck veterinary manual.’ 8th edn. (Merck & Co.: Whitehouse Station, NJ)Armbruster DA (1987) Fructosamine: structure, analysis and clinical usefulness. Clinical Chemistry 33, 2157–2163.
Arnt Brito M, Díaz Gonzáles F, Ribeiro LA, Campos R, Lacerda L, Rick Barbosa P, Bergmann G (2006) Blood and milk composition in dairy ewes from southern Brazil: variations during pregnancy and lactation. Ciência Rural 36, 942–948.
Cal Pereyra L (2007) Inducción experimental de toxemia de la gestación ovina. Aplicación a la explotación ovina en Uruguay. PhD Thesis, León University.
Campbell RM, Cuthbertson DP, Mackie W, McFarlane AS, Phillipson AT, Sudsaneh S (1961) Passage of plasma albumin into the intestine of the sheep. The Journal of Physiology 158, 113–131.
Cantley CE, Ford DM, Heath MF (1991) Serum fructosamine in ovine pregnancy toxaemia: a possible prognostic index. The Veterinary Record 128, 525–526.
| Serum fructosamine in ovine pregnancy toxaemia: a possible prognostic index.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3MzislGktA%3D%3D&md5=c44e52c707d9a5e037eb6b16efc25934CAS | 1866884PubMed |
Ceballos A, Gómez P, Vélez M, Villa N, López L (2002a) Variación de los indicadores bioquímicos del balance de energía según el estado productivo en bovinos lecheros de Manizales, Colombia. Revista Colombiana de Ciencias Pecuarias 15, 13–25.
Ceballos A, Villa NA, Andaur M, Gómez PM, Vélez ML, Escobar DM, Osorio M, Loaiza J, Wittwer F (2002b) Serum fructosamine concentration during the transitional period in Holstein and Brahman cows. In ‘Proceedings of the 10th Congress of the International Society of Animal Clinical Biochemistry, Gainesville, Florida’.
Chilliard Y (1987) Revue bibliographique: variations quantitatives et métabolisme des lipides dans les tissus adipeux et le foie au cours du cycle gestation-lactation. 2e partie: chez la brebis et la vache. Reproduction, Nutrition, Developpement 27, 327–396.
| Revue bibliographique: variations quantitatives et métabolisme des lipides dans les tissus adipeux et le foie au cours du cycle gestation-lactation. 2e partie: chez la brebis et la vache.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2sXktVCku70%3D&md5=37169d670dba7d8267e6342b51aa9fa1CAS |
Contreras PA, Möller I, Wittwer F, Tadich N (1990) Concentraciones sanguíneas de glucosa, colesterol, cuerpos cetónicos y actividad de aspartato aminotransferasa en ovejas, con gestación única y gemelar en pastoreo rotacional intensivo. Archivos de Medicina Veterinaria 22, 65–69.
Coppo JA (2001) Evolution of fructosaminaemia and glicaemia during the growth of unweaned and early weaned half-bred Zebu calves. Veterinary Research Communications 25, 449–459.
| Evolution of fructosaminaemia and glicaemia during the growth of unweaned and early weaned half-bred Zebu calves.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3Mvns1Krsw%3D%3D&md5=ed728a53f412d9cf04f26cda08cee734CAS | 11519677PubMed |
Coppo JA, Mussart de Coppo NB (1997) La glicosilación de proteínas hemáticas como evaluación retrospectiva de la glucemia. Aplicaciones en medicina veterinaria. Revista de Medicina Veterinaria 78, 292–295.
Hom FG, Ettinger B, Lin MJ (1998) Comparison of serum fructosamine vs glycohemoglobin as measures of glycemic control in a large diabetes population. Acta Diabetologica 35, 48–51.
| Comparison of serum fructosamine vs glycohemoglobin as measures of glycemic control in a large diabetes population.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXks1yht7w%3D&md5=55e6a4f215b1037479e71556d5f8e452CAS | 9625289PubMed |
Jensen AL, Petersen MB, Houe H (1993) Determination of fructosamine concentration in bovine serum samples. Journal of Veterinary Medicine A40, 111–117.
Kaneko JJ (1997) Carbohydrate metabolism and its diseases. In ‘Clinical biochemistry of domestic animals’. (Eds JJ Kaneko, JW Harvey, ML Bruss) pp. 45–81. (Academic Press: London)
Reusch CE, Lihes MR, Hoyer M, Vochezer R (1993) Fructosamine: a new parameter for diagnosis and metabolic control in diabetic dogs and cats. Journal of Veterinary Internal Medicine 7, 177–182.
| Fructosamine: a new parameter for diagnosis and metabolic control in diabetic dogs and cats.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3szitlSmtQ%3D%3D&md5=102733f2e6fdf291580b2f28cdcea7ccCAS | 8331612PubMed |
Rook JS (2000) Pregnancy toxemia of ewes, does and beef cows. The Veterinary Clinics of North America. Food Animal Practice 16, 293–317.
Russel AFJ, Doney JM, Reid RL (1967) The use of biochemical parameters in controlling nutrition state in pregnancy ewes and the effect of undernourishment during pregnancy of lamb birth weight. The Journal of Agricultural Science 68, 351–358.
| The use of biochemical parameters in controlling nutrition state in pregnancy ewes and the effect of undernourishment during pregnancy of lamb birth weight.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaF2sXks1Wqt78%3D&md5=bc5abc3a02ec7d60987ddc398383c59cCAS |
Sienra R, Bonino J, Larregui V, Echeguía M (1984) Toxemia de la preñez II. Inducción experimental y respuesta a la terapia con glicerol-propilenglicol. Veterinaria 20, 78–83.
Sorondo ML, Cirio A (2009) Evaluation of serum fructosamine test to monitor the plasma glucose concentration in the transition dairy cow. The Journal of Dairy Research 76, 173–178.
| Evaluation of serum fructosamine test to monitor the plasma glucose concentration in the transition dairy cow.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXjsl2hsrg%3D&md5=fd87a94ca8d2d5df3d1962584f3a9f5cCAS | 19121232PubMed |
Voziyan PA, Khalifah RG, Thibaudeau C, Yildiz A, Jacob J, Serianni AS, Hudson BG (2003) Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions. The Journal of Biological Chemistry 278, 46 616–46 624.
| Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXovFKksr8%3D&md5=149d6977cdf5f0cbbda69de46785e2c0CAS |
West HJ (1996) Maternal undernutrition during late pregnancy in sheep. Its relationship to maternal condition, gestation length, hepatic physiology and glucose metabolism. The British Journal of Nutrition 75, 593–605.
| Maternal undernutrition during late pregnancy in sheep. Its relationship to maternal condition, gestation length, hepatic physiology and glucose metabolism.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28XivVylsLc%3D&md5=f19ece422573860b3039863b6f41f272CAS | 8672411PubMed |
