The frontiers of biomedical science and its application to animal science in addressing the major challenges facing Australasian dairy farming
Murray D. Mitchell
A E , Mallory A. Crookenden B , Kanchan Vaswani A , John R. Roche B C D and Hassendrini N. Peiris A
+ Author Affiliations
- Author Affiliations
A Centre for Children’s Health Research, Institute of Health and Biomedical Innovation, Faculty of Health, The Queensland University of Technology, 62 Graham Street, South Brisbane, Qld 4101, Australia.
B DairyNZ Ltd, Private Bag 3221, Hamilton 3240, New Zealand.
C School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
D Present address: Ministry for Primary Industries, Pastoral House, Wellington 6140, New Zealand.
E Corresponding author. Email: murray.mitchell@qut.edu.au
Animal Production Science 60(1) 1-9 https://doi.org/10.1071/AN18579
Submitted: 10 September 2018 Accepted: 1 December 2018 Published: 21 December 2018
Journal Compilation © CSIRO 2020 Open Access CC BY-NC-ND
Abstract
Extraordinary advances are occurring in biomedical science that may revolutionise how we approach health and disease. Many have applications in the dairy industry. We have described one particular area of extracellular vesicles that have already proven to be of interest in diagnostics and prognostics for fertility and assessment of ‘transition’ cows (i.e. evaluation of the problems related to the risk of clinical diseases in dairy cows, such as mastitis and milk fever, during transition period). The addition of measurements of circulating RNA and DNA may prove of value in identifying dairy cows with higher risks of clinical diseases and potentially poor fertility. We describe the exciting opportunity provided by the possibility of generating exosomes to order as therapeutic agents to potentially enhance fertility. The even more radical concept of using exosomes to deliver a CRISPR-linked gene editing function is presented. Undoubtedly, the use of biomedical advances to assist the dairy industry is an obvious and practical approach that has significant merit.
Additional keywords: dairy cow, exosomes, fertility.
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