Nutritional strategies to alleviate heat stress in pigs
J. J. Cottrell A , F. Liu A , A. T. Hung A , K. DiGiacomo A , S. S. Chauhan A B , B. J. Leury A , J. B. Furness C , P. Celi D E F and F. R. Dunshea A G
+ Author Affiliations
- Author Affiliations
A Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Vic. 3010, Australia.
B Directorate of Animal Husbandry, Government of Himachal Pradesh, Shimla-171 005, India.
C Department of Anatomy and Neuroscience, The University of Melbourne, Vic. 3010, Australia.
D Faculty of Veterinary Science, University of Sydney, Narellan, NSW 2567, Australia.
E Present address: DSM Nutritional Products, Animal Nutrition and Health, Columbia, MD 21045, USA.
F Present address: Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Vic. 3010, Australia.
G Corresponding author. Email: fdunshea@unimelb.edu.au
Animal Production Science 55(12) 1391-1402 https://doi.org/10.1071/AN15255
Submitted: 25 May 2015 Accepted: 8 September 2015 Published: 21 October 2015
Abstract
Pigs are comparatively less heat tolerant than other species of production animals, which poses challenges for stock productivity and management during seasonal heat waves that occur in summer. The issues surrounding heat and pig production are predicted to increase, based on the actions of climate change increasing the intensity, frequency and duration of heat waves. Furthermore, future growth areas of pig production are going to be in tropical regions such as South-east Asia and Latin America. Efforts by the pig to dissipate excess body heat come at a cost to health and divert energy away from growth, compromising efficient pig production. Management of heat stress requires multiple strategies, and recent research is improving the understanding of the application of nutritional strategies to ameliorate the effects of heat stress. In particular the use of feed additives is an important, flexible and economical method to alleviate heat stress and the intensive nature of pig production lends itself to the use of additives. Some specific examples include antioxidants, betaine and chromium, which have been proved effective or being tested in mitigating some certain impacts of heat stress in pigs. The aim of this review is to summarise recent advances in the nutritional management of heat stress in pigs.
Additional keywords: hyperthermia, nutrition.
References
Akilen R, Tsiami A, Devendra D, Robinson N (2012) Cinnamon in glycaemic control: systematic review and meta analysis. Clinical Nutrition 31, 609–615.Al-Saiady MY, Al-Shaikh MA, Al-Mufarrej SI, Al-Showeimi TA, Mogawer HH, Dirrar A (2004) Effect of chelated chromium supplementation on lactation performance and blood parameters of Holstein cows under heat stress. Animal Feed Science and Technology 117, 223–233.
| Effect of chelated chromium supplementation on lactation performance and blood parameters of Holstein cows under heat stress.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXpsFSjsLk%3D&md5=52f48b83fda36a01a4f281dc58d38b1fCAS |
Alhidary IA, Shini S, Al Jassim RA, Gaughan JB (2012) Effect of various doses of injected selenium on performance and physiological responses of sheep to heat load. Journal of Animal Science 90, 2988–2994.
| Effect of various doses of injected selenium on performance and physiological responses of sheep to heat load.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsVKku7vK&md5=6ed43c71b69c33c4582b7d1b6daf89acCAS | 22585786PubMed |
Angus DJ, Hargreaves M, Dancey J, Febbraio MA (2000) Effect of carbohydrate or carbohydrate plus medium-chain triglyceride ingestion on cycling time trial performance. Journal of Applied Physiology 88, 113–119.
Attia Y, Hassan R, Qota E (2009) Recovery from adverse effects of heat stress on slow-growing chicks in the tropics 1: effect of ascorbic acid and different levels of betaine. Tropical Animal Health and Production 41, 807–818.
| Recovery from adverse effects of heat stress on slow-growing chicks in the tropics 1: effect of ascorbic acid and different levels of betaine.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1MzislKkuw%3D%3D&md5=f28868b7065a1f4b535da3442c0a1217CAS | 18987986PubMed |
Barak AJ, Beckenhauer HC, Tuma DJ (1996) Betaine, ethanol, and the liver: a review. Alcohol (Fayetteville, N.Y.) 13, 395–398.
| Betaine, ethanol, and the liver: a review.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28XlsV2rsrk%3D&md5=2478e0cfbaa69c323c0a0f2f14a1ca82CAS |
Baumgard LH, Rhoads RP (2012) Ruminant Nutrition Symposium: ruminant production and metabolic responses to heat stress. Journal of Animal Science 90, 1855–1865.
| Ruminant Nutrition Symposium: ruminant production and metabolic responses to heat stress.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XpsFWgsbg%3D&md5=cc65886e7fc38ac204305a5306dabe4aCAS | 22205665PubMed |
Baumgard LH, Rhoads RP, (2013) Effects of heat stress on postabsorptive metabolism and energetics. Annual Review of Animal Biosciences 1, 311–337.
| Effects of heat stress on postabsorptive metabolism and energetics.Crossref | GoogleScholarGoogle Scholar | 25387022PubMed |
Baumgard LH, Wheelock JB, Sanders SR, Moore CE, Green HB, Waldron MR, Rhoads RP (2011) Postabsorptive carbohydrate adaptations to heat stress and monensin supplementation in lactating Holstein cows. Journal of Dairy Science 94, 5620–5633.
| Postabsorptive carbohydrate adaptations to heat stress and monensin supplementation in lactating Holstein cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtl2qsLvM&md5=47029859a98195463d994b5f2e087532CAS | 22032385PubMed |
Belhadj Slimen I, Najar T, Ghram A, Dabbebi H, Ben Mrad M, Abdrabbah M (2014) Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review. International Journal of Hyperthermia 30, 513–523.
| Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhvVGls77E&md5=5e8c059e88c81c0c059485cd259a9875CAS |
Bell JA (1993) Selective blockade of spinal reflexes by w-conotoxin in the isolated spinal cord of the neonatal rat. Neuroscience 52, 711–716.
| Selective blockade of spinal reflexes by w-conotoxin in the isolated spinal cord of the neonatal rat.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3sXhsVWmt7k%3D&md5=cd128de4e78cc7a6cc7e4cb37001a633CAS | 7680794PubMed |
Bernabucci U, Ronchi B, Lacetera N, Nardone A (2002) Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season. Journal of Dairy Science 85, 2173–2179.
| Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XnsV2nsrk%3D&md5=738485d99013695af61379a9db3087f6CAS | 12362449PubMed |
Black JL, Mullan BP, Lorschy ML, Giles LR (1993) Lactation in the sow during heat stress. Livestock Production Science 35, 153–170.
| Lactation in the sow during heat stress.Crossref | GoogleScholarGoogle Scholar |
Borgs P, Mallard BA (1998) Immune-endocrine interactions in agricultural species: chromium and its effect on health and performance. Domestic Animal Endocrinology 15, 431–438.
| Immune-endocrine interactions in agricultural species: chromium and its effect on health and performance.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXmvVKjt70%3D&md5=d74860d90df6c00272b8460e1853671cCAS | 9785047PubMed |
Bottje WG, Carstens GE (2009) Association of mitochondrial function and feed efficiency in poultry and livestock species. Journal of Animal Science 87, E48–E63.
| Association of mitochondrial function and feed efficiency in poultry and livestock species.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1M3mtVWksQ%3D%3D&md5=dd67c11550a3402d997a3afa1f6a611dCAS | 19028862PubMed |
Brestenský M, Heger J, Nitrayová S, Patráš P (2012) Total tract digestibility of nitrogen in pigs exposed to high environmental temperatures. Journal of Animal Science 90, 101–103.
| Total tract digestibility of nitrogen in pigs exposed to high environmental temperatures.Crossref | GoogleScholarGoogle Scholar | 23365296PubMed |
Brown-Brandl TM, Nienaber JA, Xin H, Gates RS (2004) A literature review of swine heat production. Transactions of the American Society of Agricultural and Biological Engineers 47, 259–270.
| A literature review of swine heat production.Crossref | GoogleScholarGoogle Scholar |
Brown-Brandl TM, Nienaber JA, Eigenberg RA, Mader TL, Morrow JL, Dailey JW (2006) Comparison of heat tolerance of feedlot heifers of different breeds. Livestock Science 105, 19–26.
| Comparison of heat tolerance of feedlot heifers of different breeds.Crossref | GoogleScholarGoogle Scholar |
Burg MB (1995) Molecular basis of osmotic regulation. The American Journal of Physiology 268, F983–F996.
Calamari L, Petrera F, Abeni F, Bertin G (2011) Metabolic and hematological profiles in heat stressed lactating dairy cows fed diets supplemented with different selenium sources and doses. Livestock Science 142, 128–137.
| Metabolic and hematological profiles in heat stressed lactating dairy cows fed diets supplemented with different selenium sources and doses.Crossref | GoogleScholarGoogle Scholar |
Caldas T, Demont-Caulet N, Ghazi A, Richarme G (1999) Thermoprotection by glycine betaine and choline. Microbiology 145, 2543–2548.
| Thermoprotection by glycine betaine and choline.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXmsVyhtbw%3D&md5=d1f1e4d0e03b8310861531764080a9b2CAS | 10517607PubMed |
Cao H, Polansky MM, Anderson RA (2007) Cinnamon extract and polyphenols affect the expression of tristetraprolin, insuin recrptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Archives of Biochemistry and Biophysics 459, 214–222.
Chang X, Mowat DN (1992) Supplemental chromium for stressed and growing feeder calves. Journal of Animal Science 70, 559–565.
Chauhan SS, Celi P, Fahri FT, Leury BJ, Dunshea FR (2014a) Dietary antioxidants at supranutritional doses modulate skeletal muscle heat shock protein and inflammatory gene expression in sheep exposed to heat stress. Journal of Animal Science 92, 4897–4908.
| Dietary antioxidants at supranutritional doses modulate skeletal muscle heat shock protein and inflammatory gene expression in sheep exposed to heat stress.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXitVyju7nP&md5=361022cb6de141a829112e0b2675d451CAS | 25349340PubMed |
Chauhan SS, Celi P, Leury BJ, Clarke IJ, Dunshea FR (2014b) Dietary antioxidants at supranutritional doses improve oxidative status and reduce the negative effects of heat stress in sheep. Journal of Animal Science 92, 3364–3374.
| Dietary antioxidants at supranutritional doses improve oxidative status and reduce the negative effects of heat stress in sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhtlKnur3F&md5=07c310b789d460b19bc52ab54df3809dCAS | 24894002PubMed |
Chauhan SS, Celi P, Ponnampalam EN, Leury BJ, Liu F, Dunshea FR (2014c) Antioxidant dynamics in the live animal and implications for ruminant health and product (meat/milk) quality: role of vitamin E and selenium. Animal Production Science 54, 1525–1536.
| Antioxidant dynamics in the live animal and implications for ruminant health and product (meat/milk) quality: role of vitamin E and selenium.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXhsVWjtrbL&md5=675ed93bb340ad66adb0584d18062983CAS |
Chen WY, Chen CJ, Liu CH, Mao FC (2009) Chromium supplementation enhances insulin signalling in skeletal muscle of obese KK/HlJ diabetic mice. Diabetes, Obesity & Metabolism 11, 293–303.
| Chromium supplementation enhances insulin signalling in skeletal muscle of obese KK/HlJ diabetic mice.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXksF2kurc%3D&md5=a747b6ef65a69ed4722cc6d8b05195deCAS |
Christon R (1988) The effect of tropical ambient temperature on growth and metabolism in pigs. Journal of Animal Science 66, 3112–3123.
Chung J, Nguyen A-K, Henstridge DC, Holmes AG, Chan MHS, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A, Febbraio MA (2008) HSP72 protects against obesity-induced insulin resistance. Proceedings of the National Academy of Sciences of the United States of America 105, 1739–1744.
| HSP72 protects against obesity-induced insulin resistance.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhvFalsbs%3D&md5=1652998e2c1fbb3e48ffa14109b10255CAS | 18223156PubMed |
Collier RJ, Beede DK, Thatcher WW, Israel LA, Wilcox CJ (1982) Influences of environment and its modification on dairy animal health and production. Journal of Dairy Science 65, 2213–2227.
| Influences of environment and its modification on dairy animal health and production.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL3s7gvFOktg%3D%3D&md5=18cf3472cb810587b53552f45f9172b7CAS | 6759540PubMed |
Collier RJ, Collier JL, Rhoads RP, Baumgard LH (2008) Invited review: genes involved in the bovine heat stress response. Journal of Dairy Science 91, 445–454.
| Invited review: genes involved in the bovine heat stress response.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhsVais7c%3D&md5=2b46c812ee3026cecb750203159da87dCAS | 18218730PubMed |
Craig SAS (2004) Betaine in human nutrition. The American Journal of Clinical Nutrition 80, 539–549.
Cronje P (2005) Heat stress in livestock – the role of the gut in its aetiology and a potential role for betaine in its alleviation. Recent Advances in Animal Nutrition in Australia 15, 107–122.
Davis CM, Royer AC, Vincent JB (1997) Synthetic multinuclear chromium assembly activates insulin receptor kinase activity: functional model for low-molecular-weight chromium-binding substance. Inorganic Chemistry 36, 5316–5320.
| Synthetic multinuclear chromium assembly activates insulin receptor kinase activity: functional model for low-molecular-weight chromium-binding substance.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXms1Ohu74%3D&md5=85ad82c79bd8e04270a756bb4502604cCAS |
DiGiacomo K, Leury BJ, Dunshea FR (2014) Potential nutritional strategies for the amelioration or prevention of high rigor temperature in cattle – a review. Animal Production Science 54, 430–443.
| Potential nutritional strategies for the amelioration or prevention of high rigor temperature in cattle – a review.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXktlektro%3D&md5=923683aad01fa2bef6088e84869f6d6aCAS |
Dunshea FR, Harris DM, Bauman DE, Boyd RD, Bell AW (1992) Effect of somatotropin on nonesterified fatty acid and glycerol metabolism in growing pigs. Journal of Animal Science 70, 132–140.
Dunshea FR, Ostrowska E, Ferrari JM, Gill HS (2007) Dairy proteins and the regulation of satiety and obesity. Australian Journal of Experimental Agriculture 47, 1051–1058.
| Dairy proteins and the regulation of satiety and obesity.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXos1Kgur8%3D&md5=eaaf14ad042461b72a856d019b8fa6d0CAS |
Dunshea FR, Cadogan DJ, Partridge GG (2009) Dietary betaine and ractopamine combine to increase lean tissue deposition in finisher pigs, particularly gilts. Animal Production Science 49, 65–70.
| Dietary betaine and ractopamine combine to increase lean tissue deposition in finisher pigs, particularly gilts.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtVehtb4%3D&md5=eb996ed66da59ed41f2c2080d7b7f7e7CAS |
Dunshea FR, Leury BJ, Fahri F, DiGiacomo K, Hung A, Chauhan S, Clarke IJ, Collier R, Little S, Baumgard L, Gaughan JB (2013) Amelioration of thermal stress impacts in dairy cows. Animal Production Science 53, 965–975.
| Amelioration of thermal stress impacts in dairy cows.Crossref | GoogleScholarGoogle Scholar |
Eklund M, Bauer E, Wamatu J, Mosenthin R (2005) Potential nutritional and physiological functions of betaine in livestock. Nutrition Research Reviews 18, 31–48.
| Potential nutritional and physiological functions of betaine in livestock.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXntFSktLk%3D&md5=e6f4a883b5ad6dda718d109311a97cf3CAS | 19079893PubMed |
Febbraio MA (2001) Alterations in energy metabolism during exercise and heat stress. Sports Medicine (Auckland, N.Z.) 31, 47–59.
| Alterations in energy metabolism during exercise and heat stress.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M3isFaktA%3D%3D&md5=7669ffdf92c215a37dd318d9c2098671CAS |
Febbraio MA, Snow RJ, Hargreaves M, Stathis CG, Martin IK, Carey MF (1994) Muscle metabolism during exercise and heat stress in trained men: effect of acclimation. Journal of Applied Physiology 76, 589–597.
Fernández C, Gallego L, Lopez-Bote CJ (1998) Effect of betaine on fat content in growing lambs. Animal Feed Science and Technology 73, 329–338.
| Effect of betaine on fat content in growing lambs.Crossref | GoogleScholarGoogle Scholar |
Fernández-Figares I, Wray-Cahen D, Steele NC, Campbell RG, Hall DD, Virtanen E, Caperna TJ (2002) Effect of dietary betaine on nutrient utilization and partitioning in the young growing feed restricted pig. Journal of Animal Science 80, 421–428.
Finch JM, Turner RJ (1996) Effects of selenium and vitamin E on the immune responses of domestic animals. Research in Veterinary Science 60, 97–106.
| Effects of selenium and vitamin E on the immune responses of domestic animals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28Xitlaksb4%3D&md5=9719dd2d479f11b45dc12935a40f7983CAS | 8685547PubMed |
Fink WJ, Costill DL, Van Handel PJ (1975) Leg muscle metabolism during exercise in the heat and cold. European Journal of Applied Physiology and Occupational Physiology 34, 183–190.
| Leg muscle metabolism during exercise in the heat and cold.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE28Xlt1Srt7w%3D&md5=07d9a7738ffccd9423ae90aff9021c72CAS | 1181181PubMed |
Flanagan SW, Moseley PL, Buettner GR (1998) Increased flux of free radicals in cells subjected to hyperthermia: detection by electron paramagnetic resonance spin trapping. FEBS Letters 431, 285–286.
| Increased flux of free radicals in cells subjected to hyperthermia: detection by electron paramagnetic resonance spin trapping.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXks1KqtLs%3D&md5=5be584680c3fbe9aad16c3808084de2dCAS | 9708920PubMed |
Fuller MF (1965) The effect of environmental temperature on the nitrogen metabolism and growth of the young pig. British Journal of Nutrition 19, 531–546.
| The effect of environmental temperature on the nitrogen metabolism and growth of the young pig.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaF28%2FmsVOlsw%3D%3D&md5=605e1c0772d35358385529ee8af9addeCAS | 5852120PubMed |
Gabai VL, Sherman MY (2002) Molecular biology of thermoregulation: Invited Review: interplay between molecular chaperones and signaling pathways in survival of heat shock. Journal of Applied Physiology 92, 1743–1748.
| Molecular biology of thermoregulation: Invited Review: interplay between molecular chaperones and signaling pathways in survival of heat shock.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XjtVKjtLk%3D&md5=55d5a0953ff58dd690398fad84f7193cCAS | 11896044PubMed |
Gabler NK, Frouel S, Awati A, Owusu-Asiedu A, Amerah AM, Patridge GG, Dunshea FR (2013) Betaine mitigates intestinal permeability in growing pigs induced by heat stress. In ‘Manipulating pig production XIV’. (Eds JR Pluske, JM Pluske) pp. 85. (Australasian Pig Science Association (Inc.): Melbourne)
Gabler NK, Pearce SC (2015) The impact of heat stress on intestinal function and productivity in grow-finish pigs. In ‘Manipulating pig production XV’. (Eds JR Pluske, JM Pluske) pp. 1403–1410. (Australasian Pig Science Association: Melbourne)
Gaughan J, Mader T, Holt S, Sullivan M, Hahn G (2010) Assessing the heat tolerance of 17 beef cattle genotypes. International Journal of Biometeorology 54, 617–627.
| Assessing the heat tolerance of 17 beef cattle genotypes.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BC3cbntlSlsw%3D%3D&md5=b326fd616266d4e830260c9b073896eeCAS | 19458966PubMed |
Gething M-J, Sambrook J (1992) Protein folding in the cell. Nature 355, 33–45.
Gu XH, Hao Y, Wang XL (2012) Overexpression of heat shock protein 70 and its relationship to intestine under acute heat stress in broilers: 2. Intestinal oxidative stress. Poultry Science 91, 790–799.
| Overexpression of heat shock protein 70 and its relationship to intestine under acute heat stress in broilers: 2. Intestinal oxidative stress.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xls1aqsr4%3D&md5=33cf46470cf2532be04dc012257f7feaCAS | 22399716PubMed |
Hall GM, Lucke JN, Lovell R, Lister D (1980) Porcine malignant hyperthermia. VII: hepatic metabolism. British Journal of Anaesthesia 52, 11–17.
| Porcine malignant hyperthermia. VII: hepatic metabolism.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3cXht1Kgu70%3D&md5=43577b1a8dad4e7efb4d1ff4aeb1c603CAS | 6990947PubMed |
Hall DM, Baumgardner KR, Oberley TD, Gisolfi CV (1999) Splanchnic tissues undergo hypoxic stress during whole body hyperthermia. The American Journal of Physiology 276, G1195–G1203.
Hall DM, Buettner GR, Oberley LW, Xu L, Matthes RD, Gisolfi CV (2001) Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia. The American Journal of Physiology 280, H509–H521.
Hao Y, Gu XH, Wang XL (2012) Overexpression of heat shock protein 70 and its relationship to intestine under acute heat stress in broilers: 1. Intestinal structure and digestive function. Poultry Science 91, 781–789.
| Overexpression of heat shock protein 70 and its relationship to intestine under acute heat stress in broilers: 1. Intestinal structure and digestive function.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xls1aru7Y%3D&md5=48dc9bbb948b7415cc3196cd485451a0CAS | 22399715PubMed |
Hargreaves M, Angus D, Howlett K, Conus NM, Febbraio M (1996) Effect of heat stress on glucose kinetics during exercise. Journal of Applied Physiology 81, 1594–1597.
Hefnawy AE, Tortora-Perez JL (2010) The importance of selenium and the effects of its deficiency in animal health. Small Ruminant Research 89, 185–192.
| The importance of selenium and the effects of its deficiency in animal health.Crossref | GoogleScholarGoogle Scholar |
Hidiroglou N, Cave N, Atwall AS, Farnworth ER, McDowell LR (1992) Comparative vitamin E requirements and metabolism in livestock. Annales de Recherches Veterinaires 23, 337–359.
Hilder TL, Tou JCL, Grindeland RE, Wade CE, Graves LM (2003) Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle. FEBS Letters 553, 63–67.
| Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXnvFWhsL0%3D&md5=f013864808e7256338aea934bc6faab0CAS | 14550547PubMed |
Huang QC, Xu ZR, Han XY, Li WF (2006) Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine. Livestock Science 105, 78–85.
| Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine.Crossref | GoogleScholarGoogle Scholar |
Huang QC, Xu ZR, Han XY, Li WF (2007) Effect of betaine on growth hormone pulsatile secretion and serum metabolites in finishing pigs. Journal of Animal Physiology and Animal Nutrition 91, 85–90.
| Effect of betaine on growth hormone pulsatile secretion and serum metabolites in finishing pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXksFWqs78%3D&md5=74c4694891828e2b11047b840298b77eCAS | 17355337PubMed |
Huang QC, Xu ZR, Han XY, Li WF (2008) Effect of dietary betaine supplementation on lipogenic enzyme activities and fatty acid synthase mRNA expression in finishing pigs. Animal Feed Science and Technology 140, 365–375.
| Effect of dietary betaine supplementation on lipogenic enzyme activities and fatty acid synthase mRNA expression in finishing pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXlvV2ltg%3D%3D&md5=44b24bb36c1de3c37b12fd533309c731CAS |
Hung TY (2014) The effects of nano-chromium on growth performance and metabolism of pigs and sheep. PhD Thesis, The University of Melbourne.
Hung TY, Leury BJ, Lien TF, Lu JJ, Dunshea FR (2010) Potential of nano-chromium to improve body composition and performance of pigs. In ‘14th AAAP animal science congress proceedings’. pp. 108–112. (AAAP Animal Science Congress: Pingtong, Taiwan)
Hung AT, Sabin MA, Leury BJ, Dunshea FR (2012) Dietary cinnamon improves insulin sensitivity in growing pigs. In ‘Proceedings of the Nutrition Society of Australia. Volume 36’. pp. 706. (Nutrition Society of Australia (Inc.): Wollongong)
Hung A, Leury B, Sabin M, Collins C, Dunshea F (2014) Dietary nano-chromium tripicolinate increases feed intake and decreases plasma cortisol in finisher gilts during summer. Tropical Animal Health and Production 46, 1483–1489.
| Dietary nano-chromium tripicolinate increases feed intake and decreases plasma cortisol in finisher gilts during summer.Crossref | GoogleScholarGoogle Scholar | 25267321PubMed |
Hung AT, Leury BJ, Sabin MA, Lien TF, Dunshea FR (2015) Dietary chromium picolinate of varying particle size improves carcass characteristics and insulin sensitivity in finishing pigs fed low- and high-fat diets. Animal Production Science 55, 454–460.
| Dietary chromium picolinate of varying particle size improves carcass characteristics and insulin sensitivity in finishing pigs fed low- and high-fat diets.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2MXjvVOns7k%3D&md5=7987a69d3a745c898eeb090f02773f9aCAS |
Katschinski DM, Boos K, Schindler SG, Fandrey J (2000) Pivotal role of reactive oxygen species as intracellular mediators of hyperthermia-induced apoptosis. The Journal of Biological Chemistry 275, 21094–21098.
| Pivotal role of reactive oxygen species as intracellular mediators of hyperthermia-induced apoptosis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXkvFGjtb4%3D&md5=16d379f3f589e2986f9c2f41db5ad258CAS | 10781588PubMed |
Katsumata M, Yano H, Ishida N, Miyazaki A (1990) Influence of a high ambient temperature and administration of clenbuterol on body composition in rats. Journal of Nutritional Science and Vitaminology 36, 569–578.
| Influence of a high ambient temperature and administration of clenbuterol on body composition in rats.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3MXkt1yis7Y%3D&md5=63a0e67113e5469546d455d4bbefba16CAS | 2097328PubMed |
Katsumata M, Kaji Y, Saitoh M (1996) Growth and carcass fatness responses of finishing pigs to dietary fat supplementation at a high ambient temperature. Animal Science 62, 591–598.
| Growth and carcass fatness responses of finishing pigs to dietary fat supplementation at a high ambient temperature.Crossref | GoogleScholarGoogle Scholar |
Kempson SA, Parikh V, Xi L, Chu S, Montrose MH (2003) Subcellular redistribution of the renal betaine transporter during hypertonic stress. American Journal of Physiology Cell Physiology 285, C1091–C1100.
| Subcellular redistribution of the renal betaine transporter during hypertonic stress.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXpt1Kjtr0%3D&md5=1a7e36fd4723e91066f697791953d969CAS | 12839828PubMed |
Kerr BJ, Yen JT, Nienaber JA, Easter RA (2003) Influences of dietary protein level, amino acid supplementation and environmental temperature on performance, body composition, organ weights and total heat production of growing pigs. Journal of Animal Science 81, 1998–2007.
Kettunen H, Peuranen S, Tiihonen K, Saarinen M (2001) Intestinal uptake of betaine in vitro and the distribution of methyl groups from betaine, choline, and methionine in the body of broiler chicks. Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology 128, 269–278.
| Intestinal uptake of betaine in vitro and the distribution of methyl groups from betaine, choline, and methionine in the body of broiler chicks.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3M3lvVyqtg%3D%3D&md5=96d24ace0a2728746a5300e7b5dc7960CAS |
Kiefer C, dos Santos TMB, Moura MD, Silva CM, Lucas LD, Rosa EM (2012) Digestibility of diets supplemented with phytase for pigs under different thermal environments. Ciência Rural 42, 1483–1489.
| Digestibility of diets supplemented with phytase for pigs under different thermal environments.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhslGltLjM&md5=b805ac707f31c56ebc48b504ee16e03cCAS |
Kouba M, Hermier D, Le Dividich J (2001) Influence of a high ambient temperature on lipid metabolism in the growing pig. Journal of Animal Science 79, 81–87.
Lambert GP (2009) Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects. Journal of Animal Science 87, E101–E108.
| Stress-induced gastrointestinal barrier dysfunction and its inflammatory effects.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1M3mtVSrug%3D%3D&md5=40fcc87ab05b1757d7f6ca5074c39310CAS | 18791134PubMed |
Lever M, Slow S (2010) The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical Biochemistry 43, 732–744.
| The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXmsVSmsLk%3D&md5=b18c2c498ce3ff51112621186bd6b7f5CAS | 20346934PubMed |
Liu F, Cottrell JJ, Leury BJ, Chauhan SS, Celi P, Abrasaldo A, Dunshea FR (2014) Selenium or vitamin E mitigates hyperthermia in growing pigs. In ‘Proceedings of Nutritional Society of Australia annual scientific meeting. Volume 1’. pp. 22. (Nutrition Society of Australia (Inc.): Hobart, Tas.)
Liu F, Celi P, Chauhan SS, Cottrell JJ, Abrasaldo A, Talukder S, Leury BJ, Dunshea FR (2015a) Effects of heat stress and antioxidants (selenium or vitamin E) supplementation on oxidative status in growing pigs. In ‘Proceedings of American Dairy Science Association and American Society of Animal Science midwest meeting’. (American Dairy Science Association and American Society of Animal Science: Des Moines, IA)
Liu F, Cottrell JJ, Celi P, Kelly F, Wijesiriwardana D, Leury BJ, Gabler NK, Dunshea FR (2015b) Dietary selenium and vitamin E protect against small intestinal oxidative stress induced by high heat load in growing pigs. In ‘Proceedings of 13th digestive physiology of pigs’. (Eds R Zabielski, J Zentek) pp. 230. (Committee of Digestive Physiology of Pigs: Kliczkow, Poland)
Liu F, Cottrell JJ, Rivera L, Kelly F, Wijesiriwardana D, Pustovit R, Fothergill L, Melo C, Furness J, Celi P, Leury B, Gabler N, Dunshea F (2015c) Dietary selenium and vitamin E combine to reverse the effects of heat stress on intestinal barrier integrity in growing pigs. In ‘Proceedings of 13th digestive physiology of pigs’. (Eds R Zabielski, J Zentek) pp. 154. (Committee of Digestive Physiology of Pigs: Kliczkow, Poland)
Liu F, Cottrell JJ, Wijesiriwardana D, Kelly FW, Celi P, Leury BJ, Dunshea FR (2015d) Chromium supplementation alleviates heat stress in growing pigs. In ‘Proceedings of ADSA-ASAS Joint Annual Meeting (JAM)’. (Eds A Kertz, D Aaron) (American Dairy Science Association and American Society of Animal Science: Orlando, FL)
Lykkesfeldt J, Svendsen O (2007) Oxidants and antioxidants in disease: oxidative stress in farm animals. Veterinary Journal (London, England) 173, 502–511.
| Oxidants and antioxidants in disease: oxidative stress in farm animals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXlt1Sis74%3D&md5=3743a1696f160cbbe0e0d43dce92bf38CAS |
Machlin LJ, Bendich A (1987) Free radical tissue damage: protective role of antioxidant nutrients. The FASEB Journal 1, 441–445.
Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A (2006) Effects of a cinnamon extract on plasma glucose, HbAic, and serum lipids in diabetes mellitus type 2. European Journal of Clinical Investigation 36, 340–344.
Maseko T, Dunshea FR, Howell K, Cho HJ, Rivera LR, Furness JB, Ng K (2014) Selenium-enriched Agaricus bisporus mushroom protects against increase in gut permeability ex vivo and up-regulates glutathione peroxidase 1 and 2 in hyperthermally-induced oxidative stress in rats. Nutrients 6, 2478–2492.
Matthews JO, Southern LL, Bidner TD (2001a) Estimation of the total sulfur amino acid requirement and the effect of betaine in diets deficient in total sulfur amino acids for the weanling pig. Journal of Animal Science 79, 1557–1565.
Matthews JO, Southern LL, Higbie AD, Persica MA, Bidner TD (2001b) Effects of betaine on growth, carcass characteristics, pork quality and plasma metabolites of finishing pigs. Journal of Animal Science 79, 722–728.
McDowell LR, Williams SN, Hidiroglou N, Njeru CA, Hill GM, Ochoa L, Wilkinson NS (1996) Vitamin E supplementation for the ruminant. Animal Feed Science and Technology 60, 273–296.
| Vitamin E supplementation for the ruminant.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28XmvF2rsb0%3D&md5=b0b5246c5a128d77d0e6e54d44a59c06CAS |
Mendoza SM, van Heugten E, Zier-Rush CE, Boyd RD (2015) Effect of dietary betaine and ractopamine on growth and carcass characteristics in finishing pigs housed under high ambient temperatures. In ‘Proceedings of American Dairy Science Association and American Society of Animal Science midwest meeting’. (American Dairy Science Association and American Society of Animal Science: Des Moines, IA)
Moeckel GW, Shadman R, Fogel JM, Sadrzadeh SMH (2002) Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases. Life Sciences 71, 2413–2424.
| Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XmvVansLo%3D&md5=e01d2ee779878098bb35f3392633b170CAS | 12231402PubMed |
Montilla SIR, Johnson TP, Pearce SC, Gardan-Salmon D, Gabler NK, Ross JW, Rhoads RP, Baumgard LH, Lonergan SM, Selsby JT (2013) Heat stress triggers an antioxidant response in porcine skeletal muscle. FASEB Journal 27S, 1201.2
Montilla SIR, Johnson TP, Pearce SC, Gardan-Salmon D, Gabler NK, Ross JW, Rhoads RP, Baumgard LH, Lonergan SM, Selsby JT (2014) Heat stress causes oxidative stress but not inflammatory signaling in porcine skeletal muscle. Temperature 1, 42–50.
| Heat stress causes oxidative stress but not inflammatory signaling in porcine skeletal muscle.Crossref | GoogleScholarGoogle Scholar |
Mujahid A (2011) Nutritional strategies to maintain efficiency and production of chickens under high environmental temperature. Japanese Poultry Science 48, 145–154.
| Nutritional strategies to maintain efficiency and production of chickens under high environmental temperature.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtFGmt73I&md5=d610ceb2b6f68573b46450870ef3983aCAS |
Mujahid A, Yoshiki Y, Akiba Y, Toyomizu M (2005) Superoxide radical production in chicken skeletal muscle induced by acute heat stress. Poultry Science 84, 307–314.
| Superoxide radical production in chicken skeletal muscle induced by acute heat stress.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhs1ehu70%3D&md5=3e5650c347aff65bf660a4935eb52ebeCAS | 15742968PubMed |
Mujahid A, Sato K, Akiba Y, Toyomizu M (2006) Acute heat stress stimulates mitochondrial superoxide production in broiler skeletal muscle, possibly via downregulation of uncoupling protein content. Poultry Science 85, 1259–1265.
| Acute heat stress stimulates mitochondrial superoxide production in broiler skeletal muscle, possibly via downregulation of uncoupling protein content.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XntVyktrk%3D&md5=7236534ea8f2981558054bd8ed3ab123CAS | 16830867PubMed |
O’Brien MD, Rhoads RP, Sanders SR, Duff GC, Baumgard LH (2010) Metabolic adaptations to heat stress in growing cattle. Domestic Animal Endocrinology 38, 86–94.
| Metabolic adaptations to heat stress in growing cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXosFWn&md5=0021fd2ac1e9a9f7c3e9e37f3e457d4bCAS | 19783118PubMed |
Patience JF, Umboh JF, Chaplin RK, Nyachoti CM (2005) Nutritional and physiological responses of growing pigs exposed to a diurnal pattern of heat stress. Livestock Production Science 96, 205–214.
| Nutritional and physiological responses of growing pigs exposed to a diurnal pattern of heat stress.Crossref | GoogleScholarGoogle Scholar |
Patience JF, Rossoni-Serao MC, Gutierrez NA (2015) A review of feed efficiency in swine: biology and application. Journal of Animal Science and Biotechnology 6, 33
| A review of feed efficiency in swine: biology and application.Crossref | GoogleScholarGoogle Scholar | 26251721PubMed |
Pearce SC, Mani V, Boddicker RL, Johnson JS, Weber TE, Ross JW, Baumgard LH, Gabler NK (2012) Heat stress reduces barrier function and alters intestinal metabolism in growing pigs. Journal of Animal Science 90, 257–259.
| Heat stress reduces barrier function and alters intestinal metabolism in growing pigs.Crossref | GoogleScholarGoogle Scholar | 23365348PubMed |
Pearce SC, Gabler NK, Ross JW, Escobar J, Patience JF, Rhoads RP, Baumgard LH (2013a) The effects of heat stress and plane of nutrition on metabolism in growing pigs. Journal of Animal Science 91, 2108–2118.
| The effects of heat stress and plane of nutrition on metabolism in growing pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXotl2gsbg%3D&md5=77b493ac57a3563192a572e4e5cffea1CAS | 23463563PubMed |
Pearce SC, Mani V, Boddicker RL, Johnson JS, Weber TE, Ross JW, Rhoads RP, Baumgard LH, Gabler NK (2013b) Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs. PLoS One 8, e70215
| Heat stress reduces intestinal barrier integrity and favors intestinal glucose transport in growing pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXht1yqu7vL&md5=60a7d489a186ca38cb6be54c0eef3f0eCAS | 23936392PubMed |
Peng CL, Heitman H, (1974) The effect of ambient temperature on the thiamin requirement of growing-finishing pigs. British Journal of Nutrition 32, 1–9.
| The effect of ambient temperature on the thiamin requirement of growing-finishing pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE2cXltVemt7k%3D&md5=c940bbcd0d828eff8cfcc883bbe38834CAS | 4843731PubMed |
Qian L, Song X, Ren H, Gong J, Cheng S (2004) Mitochondrial mechanism of heat stress-induced injury in rat cardiomyocyte. Cell Stress & Chaperones 9, 281–293.
| Mitochondrial mechanism of heat stress-induced injury in rat cardiomyocyte.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXhtVSgsrvO&md5=f04bf6255b2657ea5facc261ae8254f2CAS |
Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y (2004) Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Hormone And Metabolic Research 36, 119–125.
Qin B, Polansky MM, Anderson RA (2010) Cinnamon extract regulates plasma levels of adipose-derived factors and expression of multiple genes related to carbohydrate metabolism and lipogenesis in adipose tissue of fructose-fed rats. Hormone and Metabolic Research 42, 187–193.
Renaudeau D, Anaïs C, Noblet J (2003) Effects of dietary fiber on performance of multiparous lactating sows in a tropical climate. Journal of Animal Science 81, 717–725.
Roffry B, Atwal A, Kudow S (2006) Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells. Molecular Nutrition and Food Research 50, 739–745.
Rojas-Cano ML, Lachica M, Lara L, Haro A, Fernández-Fígares I (2013) Portal-drained viscera heat production in pigs fed betaine and conjugated linoleic acid (CLA) supplemented diets. In ‘Energy and protein metabolism and nutrition in sustainable animal production – EAAP Scientific Series, publication no. 134’. (Eds JW Oltjen, E Kebreab, H Lapierre) p. 433. (Wageningen Academic Publishers: Wageningen)
Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium – biochemical role as a component of glutathione peroxidase. Science 179, 588–590.
| Selenium – biochemical role as a component of glutathione peroxidase.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE3sXps1ensg%3D%3D&md5=4a20f78e6d13ae1e843fe9b7fbb30457CAS | 4686466PubMed |
Sahin K, Ozbey O, Onderci M, Cikim G, Aysondu MH (2002a) Chromium supplementation can alleviate negative effects of heat stress on egg production, egg quality and some serum metabolites of laying Japanese quail. The Journal of Nutrition 132, 1265–1268.
Sahin K, Sahin N, Onderci M (2002b) Vitamin E supplementation can alleviate negative effects of heat stress on egg production, egg quality, digestibility of nutrients and egg yolk mineral concentrations of Japanese quails. Research in Veterinary Science 73, 307–312.
| Vitamin E supplementation can alleviate negative effects of heat stress on egg production, egg quality, digestibility of nutrients and egg yolk mineral concentrations of Japanese quails.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXltF2ksg%3D%3D&md5=9e8be470ca41a5533c85ee121648da21CAS | 12443690PubMed |
Sahin K, Sahin N, Kucuk O (2003) Effects of chromium, and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant status of broiler chickens reared at a high ambient temperature. Nutrition Research (New York, N.Y.) 23, 225–238.
| Effects of chromium, and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant status of broiler chickens reared at a high ambient temperature.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXhvFajtLs%3D&md5=cab236eea4b5d8f5ec4fb9288f3c6f52CAS |
Sahin N, Sahin K, Onderci M, Gursu MF, Cikim G, Vijaya J, Kucuk O (2005) Chromium picolinate, rather than biotin, alleviates performance and metabolic parameters in heat-stressed quail. British Poultry Science 46, 457–463.
| Chromium picolinate, rather than biotin, alleviates performance and metabolic parameters in heat-stressed quail.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXpslyrsb4%3D&md5=6d8a064e3ba60bd68661fa295bcb8f99CAS | 16268103PubMed |
Sahin K, Orhan C, Smith MO, Sahin N (2013) Molecular targets of dietary phytochemicals for the alleviation of heat stress in poultry. World’s Poultry Science Journal 69, 113–124.
| Molecular targets of dietary phytochemicals for the alleviation of heat stress in poultry.Crossref | GoogleScholarGoogle Scholar |
Sales J (2011) A meta-analysis of the effects of dietary betaine supplementation on finishing performance and carcass characteristics of pigs. Animal Feed Science and Technology 165, 68–78.
| A meta-analysis of the effects of dietary betaine supplementation on finishing performance and carcass characteristics of pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXktFyhsLc%3D&md5=c27ee59ffe56cb06d313bb7c1ee3b347CAS |
Samanta S, Haldar S, Bahadur V, Ghosh TK (2008) Chromium picolinate can ameliorate the negative effects of heat stress and enhance performance, carcass and meat traits in broiler chickens by reducing the circulatory cortisol level. Journal of the Science of Food and Agriculture 88, 787–796.
| Chromium picolinate can ameliorate the negative effects of heat stress and enhance performance, carcass and meat traits in broiler chickens by reducing the circulatory cortisol level.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjsleqt7g%3D&md5=8c85feab046f9033dbbc269db459fb52CAS |
Sanz Fernandez MV, Johnson JS, Abuajamieh M, Stoakes SK, Seibert JT, Cox L, Kahl S, Elsasser TH, Ross JW, Isom SC, Rhoads RP, Baumgard LH (2015a) Effects of heat stress on carbohydrate and lipid metabolism in growing pigs. Physiological Reports 3, e12315
| Effects of heat stress on carbohydrate and lipid metabolism in growing pigs.Crossref | GoogleScholarGoogle Scholar |
Sanz Fernandez MV, Stoakes SK, Abuajamieh M, Seibert JT, Johnson JS, Horst EA, Rhoads RP, Baumgard LH (2015b) Heat stress increases insulin sensitivity in pigs. Physiological Reports 3, e12478
| Heat stress increases insulin sensitivity in pigs.Crossref | GoogleScholarGoogle Scholar | 26243213PubMed |
Schrama JW, Heetkamp MJW, Simmins PH, Gerrits WJJ (2003) Dietary betaine supplementation affects energy metabolism of pigs. Journal of Animal Science 81, 1202–1209.
Schuman SH (1972) Patterns of urban heat-wave deaths and implications for prevention: data from New York and St. Louis during July, 1966. Environmental Research 5, 59–75.
| Patterns of urban heat-wave deaths and implications for prevention: data from New York and St. Louis during July, 1966.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaE383gsFSitg%3D%3D&md5=ae08ea683168acfd270d8ec964ca68abCAS | 5032925PubMed |
Schwahn BC, Hafner D, Hohlfeld T, Balkenhol N, Laryea MD, Wendel U (2003) Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria. British Journal of Clinical Pharmacology 55, 6–13.
Semenza JC, McCullough JE, Flanders WD, McGeehin MA, Lumpkin JR (1999) Excess hospital admissions during the July 1995 heat wave in Chicago. American Journal of Preventive Medicine 16, 269–277.
| Excess hospital admissions during the July 1995 heat wave in Chicago.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK1MvitFShtg%3D%3D&md5=476e673853c0467ee978ea6ded8e7975CAS | 10493281PubMed |
Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ (2008) Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors. PPAR Research 2008.
Sizeland PC, Chambers ST, Lever M, Bason LM, Robson RA (1993) Organic osmolytes in human and other mammalian kidneys. Kidney International 43, 448–453.
| Organic osmolytes in human and other mammalian kidneys.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3s7otVertw%3D%3D&md5=2d2d2fd508052080103d20e26a4d64d6CAS | 8441242PubMed |
Soares AD, Costa KA, Wanner SP, Santos RG, Fernandes SO, Martins FS, Nicoli JR, Coimbra CC, Cardoso VN (2014) Dietary glutamine prevents the loss of intestinal barrier function and attenuates the increase in core body temperature induced by acute heat exposure. British Journal of Nutrition 112, 1601–1610.
| Dietary glutamine prevents the loss of intestinal barrier function and attenuates the increase in core body temperature induced by acute heat exposure.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC2cXitVChu7zK&md5=eb90146647a5d67864b5524bb8276a25CAS | 25322775PubMed |
Sordillo LM, Raphael W (2013) Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders. The Veterinary Clinics of North America. Food Animal Practice 29, 267–278.
| Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders.Crossref | GoogleScholarGoogle Scholar | 23809891PubMed |
Spencer JD, Gaines AM, Berg EP, Allee GL (2005) Diet modifications to improve finishing pig growth performance and pork quality attributes during periods of heat stress. Journal of Animal Science 83, 243–254.
St-Pierre NR, Cobanov B, Schnitkey G (2003) Economic losses from heat stress by US Livestock Industries. Journal of Dairy Science 86, E52–E77.
| Economic losses from heat stress by US Livestock Industries.Crossref | GoogleScholarGoogle Scholar |
Stahly TS, Cromwell GL, Aviotti MP (1979) The effect of environmental temperature and dietary lysine source and level on the performance and carcass characteristics of growing swine. Journal of Animal Science 49, 1242–1251.
Suster D, Leury BJ, King RH, Mottram M, Dunshea FR (2004) Interrelationships between porcine somatotropin (pST), betaine, and energy level on body composition and tissue distribution of finisher boars. Australian Journal of Agricultural Research 55, 983–990.
| Interrelationships between porcine somatotropin (pST), betaine, and energy level on body composition and tissue distribution of finisher boars.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXnvVKiurk%3D&md5=93067a9662fe094cf4e012ac4687e151CAS |
Suttle NF (2010) ‘Mineral nutrition of livestock.’ 4th edn. (CAB International: Oxfordshire, UK)
Suzuki M, Yasumoto E, Baba S, Ashihara H (2003) Effect of salt stress on the metabolism of ethanolamine and choline in leaves of the betaine-producing mangrove species Avicennia marina. Phytochemistry 64, 941–948.
| Effect of salt stress on the metabolism of ethanolamine and choline in leaves of the betaine-producing mangrove species Avicennia marina.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXotVeqsL0%3D&md5=705314bd6383a493df383ff6ff69daa1CAS | 14561509PubMed |
Verstegen MW, Close WH, Start IB, Mount LE (1973) The effects of environmental temperature and plane of nutrition on heat loss, energy retention and deposition of protein and fat in groups of growing pigs. British Journal of Nutrition 30, 21–35.
| The effects of environmental temperature and plane of nutrition on heat loss, energy retention and deposition of protein and fat in groups of growing pigs.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE3sXltVequr8%3D&md5=973ae6668856d095807eb9347967d68eCAS | 4720731PubMed |
Wheelock JB, Rhoads RP, VanBaale MJ, Sanders SR, Baumgard LH (2010) Effects of heat stress on energetic metabolism in lactating Holstein cows. Journal of Dairy Science 93, 644–655.
| Effects of heat stress on energetic metabolism in lactating Holstein cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXht1CjtLY%3D&md5=efe9ce05fb26a5d6eb876885db73c7f3CAS | 20105536PubMed |
Williams AM, Safranski TJ, Spiers DE, Eichen PA, Coate EA, Lucy MC (2013) Effects of a controlled heat stress during late gestation, lactation, and after weaning on thermoregulation, metabolism, and reproduction of primiparous sows. Journal of Animal Science 91, 2700–2714.
| Effects of a controlled heat stress during late gestation, lactation, and after weaning on thermoregulation, metabolism, and reproduction of primiparous sows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXpvFCrsbc%3D&md5=100515b34d0c37544896dc490d3c7133CAS | 23508026PubMed |
Willshire JA, Payne JH (2011) Selenium and vitamin E in dairy cows – a review. Cattle Practitioner 19, 22–30.
Wray-Cahen D, Fernández-Fígares I, Virtanen E, Steele NC, Caperna TJ (2004) Betaine improves growth, but does not induce whole body or hepatic palmitate oxidation in swine (Sus scrofa domestica). Comparative Biochemistry and Physiology. A. Comparative Physiology 137, 131–140.
| Betaine improves growth, but does not induce whole body or hepatic palmitate oxidation in swine (Sus scrofa domestica).Crossref | GoogleScholarGoogle Scholar |
Xavier IJ, Mercier PA, McLoughlin CM, Ali A, Woodgett JR, Ovsenek N (2000) Glycogen synthase kinase 3beta negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1. The Journal of Biological Chemistry 275, 29147–29152.
| Glycogen synthase kinase 3beta negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXms1Cqtbk%3D&md5=d54501b3c28585864971328c177280e0CAS | 10856293PubMed |
Yancey PH, Burg MB (1990) Counteracting effects of urea and betaine in mammalian-cells in culture. The American Journal of Physiology 258, R198–R204.
Yang CY, Lin MT (2002) Oxidative stress in rats with heatstroke-induced cerebral ischemia. Stroke 33, 790–794.
| Oxidative stress in rats with heatstroke-induced cerebral ischemia.Crossref | GoogleScholarGoogle Scholar | 11872905PubMed |
Yen YT (1997) Oxygen consumption and energy flux of porcine splanchnic tissues. In ‘Digestive physiology in pigs. Proceedings of the 7th international symposium on the digestive physiology in pigs. Vol. 88’. (Eds JP Laplace, C Fevrier, A Barbeau) pp. 260–269. (Institut National de la Recherche Agronomique: Saint Malo, France)
Yen JT, Nienaber JA, Hill DA, Pond WG (1989) Oxygen consumption by portal vein-drained organs and by whole animal in conscious growing swine. Proceedings of the Society for Experimental Biology and Medicine 190, 393–398.
| Oxygen consumption by portal vein-drained organs and by whole animal in conscious growing swine.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaL1M7osVKrtw%3D%3D&md5=dd067aabbb0105c21955d91bc111dcadCAS | 2928354PubMed |
Zeisel SH, Blusztajn JK (1994) Choline and human nutrition. Annual Review of Nutrition 14, 269–296.
| Choline and human nutrition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXmtVeqsL0%3D&md5=8a349bc166a497f04ba6aaa854203724CAS | 7946521PubMed |
Zha L-Y, Jing-Wen Z, Xin-Wei C, Li-Mei M, Hai-Ji L (2009) Efficacy of trivalent chromium on growth performance, carcass characteristics and tissue chromium in heat-stressed broiler chicks. Journal of the Science of Food and Agriculture 89, 1782–1786.
| Efficacy of trivalent chromium on growth performance, carcass characteristics and tissue chromium in heat-stressed broiler chicks.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXos1Git7g%3D&md5=a0d463a2b6388a480ce80b89b2c49fa2CAS |
