Effect of dietary potassium supplementation on the calcium absorption capacity in the rumen and abomasum and fractional excretion of urinary minerals in sheep
M. S. Bhanugopan A B C , W. J. Fulkerson A , M. Hyde A and D. R. Fraser A
+ Author Affiliations
- Author Affiliations
A Faculty of Veterinary Science, University of Sydney, Camden, NSW 2570, Australia.
B Current address: School of Animal & Veterinary Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
C Corresponding author. Email: mbhanugopan@csu.edu.au
Animal Production Science 55(4) 508-514 https://doi.org/10.1071/AN12366
Submitted: 17 October 2012 Accepted: 4 December 2013 Published: 28 January 2014
Abstract
The aim of this study was to determine the effect of potassium (K) supplementation on the calcium (Ca) absorption capacity from the rumen and abomasum of sheep. The Ca absorption capacity from the rumen and abomasum of sheep was measured using stable strontium (Sr) as a Ca-analogue tracer method. The sheep, cannulated at either the rumen or abomasum, were randomly allocated to one of two groups (control or K-supplemented) and fed in individual metabolism pens twice daily with a diet comprising oaten hay, lucerne chaff and barley fortified with or without potassium carbonate (K2CO3). The K content of the diet of the K-supplemented animals was 3.1% of dry matter compared with 1.4% for the control animals. The animals were fed their respective diets for a period of 2 weeks. The fractional absorption capacity (FC) of Ca was estimated before, during and after the treatment period. Supplementation with K decreased the FC of Ca in both the rumen and abomasum during treatment and increased the FC of Ca in the abomasum post-treatment. Supplementation with K also increased the fractional excretion of K in the urine, but decreased the fractional excretion of Ca and magnesium (Mg) (P < 0.05), showing that K supplementation significantly affected Ca and Mg metabolism. Results suggest that renal conservation of Ca and Mg is an important mechanism controlling the Ca and Mg pool for vital functions of the body. In times of high demand for these minerals during lactation and pregnancy, high K in the diets may predispose sheep to hypomagnesaemia and hypocalcaemia, which in turn will have a negative impact on productivity and economic returns.
Additional keywords: potassium, calcium absorption, fractional excretion, magnesium.
References
Arden NK, Major P, Poole JR, Keen RW, Vaja S, Swaminathan R, Cooper C, Spector TD (2002) Size at birth, adult intestinal calcium absorption and 1,25 (OH)2 vitamin D. The Quarterly Journal of Medicine 95, 15–21.| Size at birth, adult intestinal calcium absorption and 1,25 (OH)2 vitamin D.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD387jt1OrsQ%3D%3D&md5=4109b0bca83e468f0ae91890d7c8c85cCAS |
Asai H, Hayashi N, Takai N, Yoshimura Y, Nakamura Y, Yokota H, Kita K (2005) Estimation of daily urinary potassium excretion using urinary creatinine as an index substance in prepartum dairy cows. Journal of Animal Science 76, 51–54.
| Estimation of daily urinary potassium excretion using urinary creatinine as an index substance in prepartum dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXjsFejsLY%3D&md5=46435638a852c37844d688b974d4919fCAS |
Bhanugopan MS, Fulkerson WJ, Fraser DR, Hyde ML, McNeill DM (2010) Carryover effects of potassium supplementation on calcium homeostasis in dairy cows at parturition. Journal of Dairy Science 93, 2119–2129.
| Carryover effects of potassium supplementation on calcium homeostasis in dairy cows at parturition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXnvVansrk%3D&md5=c25a1b0e5d842f7b7c7fd695e4cdd6cbCAS | 20412927PubMed |
Block E (1984) Manipulating dietary anions and cations for prepartum dairy cows to reduce incidence of milk fever. Journal of Dairy Science 67, 2939–2948.
| Manipulating dietary anions and cations for prepartum dairy cows to reduce incidence of milk fever.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2MXhtFWqtrk%3D&md5=79b5b1ff2c64bfb5e0f45190288850c4CAS | 6530489PubMed |
Block E (1994) Manipulation of dietary cation-anion difference on nutritionally related production diseases, productivity and metabolic responses of dairy cows. Journal of Dairy Science 77, 1437–1450.
| Manipulation of dietary cation-anion difference on nutritionally related production diseases, productivity and metabolic responses of dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2cXltlakt7s%3D&md5=49827eb6971e85caee16f287adaa635cCAS | 8046083PubMed |
Bolscher MD, Netelenbos JC, Barto R, van der Vijgh WJF (2000) Strontium as a marker for intestinal calcium absorption: The stimulatory effect of calcitriol. Clinical Chemistry 46, 248–251.
Braithwaite GD (1976) Reviews of progress of dairy science – Calcium and phosphorus-metabolism in ruminants with special reference to parturient paresis. The Journal of Dairy Research 43, 501–520.
| Reviews of progress of dairy science – Calcium and phosphorus-metabolism in ruminants with special reference to parturient paresis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaE2sXmvFensQ%3D%3D&md5=8259f53412f0a544db9e1d666f667ae7CAS | 791979PubMed |
Care AD, Brown RC, Farrar AR, Pickard DW (1984) Magnesium absorption from the digestive tract of sheep. Quarterly Journal of Experimental Physiology (Cambridge, England) 69, 577–587.
Charbonneau ED, Pellerin D, Oetzel GR (2006) Impact of lowering dietary cation –anion difference in non lactating dairy cows: A meta-analysis. Journal of Dairy Science 89, 537–548.
| Impact of lowering dietary cation –anion difference in non lactating dairy cows: A meta-analysis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtlWrtrg%3D&md5=98ed6f6b7cdf0f14380fd2e96ae0efcbCAS |
Charlton JA, Armstrong DG (1989) The effect of an intravenous infusion of aldosterone upon magnesium metabolism in sheep. Quarterly Journal of Experimental Physiology (Cambridge, England) 74, 329–337.
Dove H, McMullen KG (2009) Diet selection, herbage intake and liveweight gain in young sheep grazing dual-purpose wheats and their responses to mineral supplements. Animal Production Science 49, 749–758.
| Diet selection, herbage intake and liveweight gain in young sheep grazing dual-purpose wheats and their responses to mineral supplements.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtFelsbvL&md5=3bd034d109510d8e57c297e52b51cdffCAS |
Dove H, Kirkegaard J, Kelman W, Sprague S, Hamblin P (2011) Integrating dual-purpose crops – capturing the whole farm benefits. In ‘Grains Research Technical update, Young, NSW, 15–16 February 2011’. (Eds K Tooney, J Crane) pp. 141–148. (ORM Communications: Bendigo, Vic.)
Dove H, Kelman WM, Kirkegaard JA, Sprague SJ (2012) Impact of magnesium–sodium supplementation on liveweight gains of young sheep grazing dual -purpose cereal or canola crops. Animal Production Science 52, 1027–1035.
| Impact of magnesium–sodium supplementation on liveweight gains of young sheep grazing dual -purpose cereal or canola crops.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsVCgtbrO&md5=d7abbbc6733a12882406eae5fd3914ddCAS |
Dua K (2002) Absorption of magnesium, calcium, sodium, potassium, chloride and phosphate from the isolated reticulo-rumen and the effect of increasing the intraruminal potassium concentrations on the absorption of these electrolytes in sheep. The Indian Journal of Animal Sciences 72, 674–676.
Fisher LJ, Dinn N, Tait RM, Shelford JA (1994) Effect of level of dietary potassium on the absorption and excretion of calcium and magnesium by lactating cows. Canadian Journal of Animal Science 74, 503–509.
| Effect of level of dietary potassium on the absorption and excretion of calcium and magnesium by lactating cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2MXhvFOrsLw%3D&md5=b13ae1313080b59f506f88915da96362CAS |
Fredeen AH (1990) Effects of calcium loss and high dietary calcium and potassium on calcium kinetics and magnesium balance in sheep fed low magnesium diets. Canadian Journal of Animal Science 70, 1109–1117.
| Effects of calcium loss and high dietary calcium and potassium on calcium kinetics and magnesium balance in sheep fed low magnesium diets.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3MXhvVCisLk%3D&md5=0ab0083d90f0ac3ef7445f81964879b0CAS |
Goff JP (2008) The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Veterinary Journal (London, England) 176, 50–57.
| The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjs1Srtr4%3D&md5=40ebc19e238c0e7ce51dd82fa03029eeCAS |
Goff JP, Horst RL (1997) Effects of the addition of potassium or sodium, but not calcium, to prepartum rations on milk fever in dairy cows. Journal of Dairy Science 80, 176–186.
| Effects of the addition of potassium or sodium, but not calcium, to prepartum rations on milk fever in dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXpvFamtw%3D%3D&md5=db2957f13272ab1caa8ac917d6eb8abbCAS | 9120088PubMed |
Grace N, Ulyatt M, Macrae J (1974) Quantitative digestion of fresh herbage by sheep III. The movement of Mg, Ca, P, K, and Na in the digestive tract. The Journal of Agricultural Science 82, 321–330.
| Quantitative digestion of fresh herbage by sheep III. The movement of Mg, Ca, P, K, and Na in the digestive tract.Crossref | GoogleScholarGoogle Scholar |
Greene LW, Fontenot JP, Webb KE (1983) Site of magnesium and other macromineral absorption in steers fed high levels of potassium. Journal of Animal Science 57, 503–510.
Greene LW, Fontenot JP, Webb KR (1983a) Effect of dietary potassium on absorption of magnesium and other macroelements in sheep fed different levels of magnesium. Journal of Animal Science 56, 1208
Greene LW, Webb KE, Fontenot JP (1983b) Effect of potassium level on site of absorption of magnesium and other macroelements in sheep. Journal of Animal Science 56, 1214–1221.
Grings EE, Males JR (1987) Effects of potassium on macromineral absorption in sheep fed wheat straw-based diets. Journal of Animal Science 64, 872–879.
Holler H, Breves G, Kocabatmaz M, Gerdes H (1988) Flux of calcium across the sheep rumen wall in vivo and in vitro. Quarterly Journal of Experimental Physiology (Cambridge, England) 73, 609–618.
Hyde ML (1994) The role of vitamin D metabolites in the development of milk-fever in dairy cows. PhD thesis. University of Sydney, NSW, Australia.
Hyde ML, Fraser DR (1996) ‘Manipulating the cow’s calcium reserves to minimise the incidence of milk fever. Current topics in Dairy Production Vol. 1.’ (Dairy Research Foundation, The University of Sydney: Camden, NSW)
Kaneko JJ, Harvey JW, Bruss ML (2008) ‘Clinical biochemistry of domestic animals.’ 6th edn (Academic Press/Elsevier: Amsterdam, Boston) (ebook)
Khorasani GR, Armstrong DG (1992) Calcium, phosphorus and magnesium absorption and secretion in the bovine digestive tract as influenced by dietary concentration of these elements. Livestock Production Science 31, 271–286.
| Calcium, phosphorus and magnesium absorption and secretion in the bovine digestive tract as influenced by dietary concentration of these elements.Crossref | GoogleScholarGoogle Scholar |
Kronfeld DS (1971) Parturient hypocalcaemia in dairy cows. Advances in Veterinary Science and Comparative Medicine 15, 133–157.
Lean IJ, Degaris PJ, McNeil DM, Block E (2006) Hypocalcaemia in dairy cows : meta-analysis and dietary cation anion difference theory revisited. Journal of Dairy Science 89, 669–684.
| Hypocalcaemia in dairy cows : meta-analysis and dietary cation anion difference theory revisited.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtlWrtL4%3D&md5=2ab59e0987266c7ff66313c78a1d32b9CAS | 16428636PubMed |
Lefebvre HP, Dossin O, Trumel C, Braun JP (2008) Fractional excretion tests: a critical review of methods and applications in domestic animals. Veterinary Clinical Pathology 37, 4–20.
| Fractional excretion tests: a critical review of methods and applications in domestic animals.Crossref | GoogleScholarGoogle Scholar | 18366540PubMed |
Martens H, Kubel OW, Gabel G, Honig H (1987) Effects of low sodium intake on magnesium metabolism of sheep. Journal of Agricultural Science, Cambridge 108, 237–243.
| Effects of low sodium intake on magnesium metabolism of sheep.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL2sXktlynsrc%3D&md5=821a30c95fb26dc14661d97998273e43CAS |
McNeill DM, Roche JR, Mclachlan BP, Stockdale CR (2002) Nutritional strategies for the prevention of hypocalcaemia at calving for dairy cows in pasture-based systems. Australian Journal of Agricultural Research 53, 755–770.
| Nutritional strategies for the prevention of hypocalcaemia at calving for dairy cows in pasture-based systems.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xmt1GmtL0%3D&md5=453039c1dd39e6362e6f88332a9705fcCAS |
Newton GL, Tucke RE, Fontenot JP, Polan CE (1972) Effects of high dietary potassium intake on metabolism of magnesium by sheep. Journal of Animal Science 35, 440
Ram L, Schonewille JT, Martens H, Van’t Klooster AT, Beynen AC (1998) Magnesium absorption by wethers fed potassium bicarbonate in combination with different dietary magnesium concentrations. Journal of Dairy Science 81, 2485–2492.
| Magnesium absorption by wethers fed potassium bicarbonate in combination with different dietary magnesium concentrations.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXmsVCrtro%3D&md5=5a80ffc08dd8a42bdb7942732b0403caCAS | 9785240PubMed |
Schachter D, Dowdle EB, Schenker H (1960) Accumulation of Ca-45 by slices of the small intestine. The American Journal of Physiology 198, 275–279.
Schonewille JT, Ram L, Van’t Klooster AT, Wouterse H, Beyen AC (1997) Intrinsic potassium in grass silage and magnesium absorption in dry cows. Livestock Production Science 48, 99–110.
| Intrinsic potassium in grass silage and magnesium absorption in dry cows.Crossref | GoogleScholarGoogle Scholar |
Schröder B, Breves G (2006) Mechanisms and regulation of calcium absorption from the gastrointestinal tract in pigs and ruminants: comparative aspects with special emphasis on hypocalcemia in dairy cows. Animal Health Research Reviews 7, 31–41.
| Mechanisms and regulation of calcium absorption from the gastrointestinal tract in pigs and ruminants: comparative aspects with special emphasis on hypocalcemia in dairy cows.Crossref | GoogleScholarGoogle Scholar | 17389052PubMed |
Schweigel M, Voigt J, Mohr E (2009) Indication of intracellular magnesium deficiency in lactating dairy cows revealed by magnesium loading and renal fractional excretion. Journal of Animal Physiology and Animal Nutrition 93, 105–112.
| Indication of intracellular magnesium deficiency in lactating dairy cows revealed by magnesium loading and renal fractional excretion.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXivFWjsr8%3D&md5=7cb16146d562d753d94657044a2707cfCAS | 19386014PubMed |
Suttle NF (2010) Calcium. In ‘The mineral nutrition of livestock’. 4th edn. Ch. 4, pp. 75–76. (CAB International Ltd: Wallingford UK)
Underwood EJ, Suttle NF (1999) ‘The mineral nutrition of livestock.’ 3rd edn (CAB International Ltd: Wallingford UK)
van Mosel M, van ’t Klooster AT, Wouterse HS (1991) Effects of a deficient magnesium supply during the dry period on bone turnover of dairy cows at parturition. The Veterinary Quarterly 13, 199–208.
| Effects of a deficient magnesium supply during the dry period on bone turnover of dairy cows at parturition.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK387jt12rsg%3D%3D&md5=463f81634c294a0dd24431fcefed4203CAS | 1776234PubMed |
Wadhwa DR, Care AD (2000) Effects of strontium on the absorption of calcium. Magnesium and phosphate ions from the ovine reticulo-rumen. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology 170, 225–229.
| Effects of strontium on the absorption of calcium. Magnesium and phosphate ions from the ovine reticulo-rumen.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXkt1Gju7Y%3D&md5=a9e870f31c644ebbe7467f14010df6b5CAS | 10841263PubMed |
Wilson GF (2001) Stimulation of calcium absorption and reduction in susceptibility to fasting induced hypocalcaemia in pregnant ewes fed vegetable oil. New Zealand Veterinary Journal 49, 115–118.
| Stimulation of calcium absorption and reduction in susceptibility to fasting induced hypocalcaemia in pregnant ewes fed vegetable oil.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXkslGksLo%3D&md5=47378dd5983b8ce889fdef6a8c6ca6f2CAS | 16032174PubMed |
Wylie MJ, Fontenot JP, Greene LW (1985) Absorption of magnesium and other macrominerals in sheep infused with potassium in different parts of the digestive-tract. Journal of Animal Science 61, 1219–1229.
