Functional welfare – using biochemical and molecular technologies to understand better the welfare state of peripartal dairy cattle
J. J. Loor A D , G. Bertoni B , A. Hosseini A , J. R. Roche C and E. Trevisi B
+ Author Affiliations
- Author Affiliations
A Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois 61801, USA.
B Istituto di Zootecnica, Facoltà di Agraria, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy.
C DairyNZ, Hamilton, New Zealand.
D Corresponding author. Email: jloor@illinois.edu
Animal Production Science 53(9) 931-953 https://doi.org/10.1071/AN12344
Submitted: 29 September 2012 Accepted: 23 April 2013 Published: 4 June 2013
Abstract
Animal welfare is an important social construct showing that humans recognise the sentient nature of animals and manage them accordingly; however, because the concept differs depending on individual perceptions of the acceptability of different practices and appropriate endpoint measurements, objective evaluation of an animal’s welfare state is challenging. A good level of welfare, however, is not achieved merely by the absence of difficulties (e.g. pain, injury, disease, distress) but by the animal’s capacity to overcome them. Production-oriented (utilitarian) opinions contend that high production indicates good welfare, as an animal must be healthy and well nourished to achieve it. Although there is truth in this premise, high production can, in itself, result in stresses, with no obvious signs that potentially predispose animals to ill health. The focus of the present paper is on peripartal dairy cattle as it relates to development of better measures for an objective evaluation of welfare state. Advances in high-throughput metabolite (metabolomics) and gene expression (transcriptomics) analysis techniques have enabled the rapid identification of multiple biomarkers that, in combination, reflect the metabolic and immunocompetence functional capacity of the animal. With this knowledge, the effects of management, nutrition, physiological state, and their interactions can be evaluated for their effect on functional capacity. As the links between metabolism, immunology (immunometabolism) and mental state are elucidated, these techniques also offer a means to assess whether the animal also experiences feelings of malaise. Collectively, these measurements, thus, can indicate ‘functional welfare’, which encompasses biological function, physical state, and some components of mental state as part of animal welfare.
References
Akbar H, Bionaz M, Carlson DB, Rodriguez-Zas SL, Everts RE, Lewin HA, Drackley JK, Loor JJ (2013) Feed restriction, but not l-carnitine infusion, alters the liver transcriptome by inhibiting sterol synthesis and mitochondrial oxidative phosphorylation and increasing gluconeogenesis in mid-lactation dairy cows. Journal of Dairy Science 96, 2201–2213.| Feed restriction, but not l-carnitine infusion, alters the liver transcriptome by inhibiting sterol synthesis and mitochondrial oxidative phosphorylation and increasing gluconeogenesis in mid-lactation dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXjtVShurk%3D&md5=0909a22f832213d448651a33da7492b1CAS | 23462174PubMed |
Allen MS, Bradford BJ, Harvatine KJ (2005) The cow as a model to study food intake regulation. Annual Review of Nutrition 25, 523–547.
| The cow as a model to study food intake regulation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXpvF2mt7s%3D&md5=013ecfd4d9777f43fc6ef496b21f877aCAS | 16011477PubMed |
Arita M, Clish CB, Serhan CN (2005) The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids. Biochemical and Biophysical Research Communications 338, 149–157.
| The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFylu7fN&md5=9e4ec0a4ff7c8aed50092a4805113fa0CAS | 16112645PubMed |
Barnes PJ (1997) Nuclear factor-kappa B. The International Journal of Biochemistry & Cell Biology 29, 867–870.
| Nuclear factor-kappa B.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXmt1Giu7o%3D&md5=17bb22b6103466edd4ff5caa112a2bf2CAS |
Barros RP, Gustafsson JA (2011) Estrogen receptors and the metabolic network. Cell Metabolism 14, 289–299.
| Estrogen receptors and the metabolic network.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtFGltbnI&md5=0a65c3432b5a19338c93e415aaa61a3aCAS | 21907136PubMed |
Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. European Cytokine Network 17, 4–12.
Bauman DE, Currie WB (1980) Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis. Journal of Dairy Science 63, 1514–1529.
| Partitioning of nutrients during pregnancy and lactation: a review of mechanisms involving homeostasis and homeorhesis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3cXmtFygu7s%3D&md5=22d428d926dd550f4fa2dfef473aa9d5CAS | 7000867PubMed |
Belloque J, Ramos M (2002) Determination of the casein content in bovine milk by 31P-NMR. The Journal of Dairy Research 69, 411–418.
| Determination of the casein content in bovine milk by 31P-NMR.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XnslSgt7s%3D&md5=632c7d2d3e95aab07c2f47e4cf9d14d7CAS | 12369412PubMed |
Bernabucci U, Ronchi B, Basirico L, Pirazzi D, Rueca F, Lacetera N, Nardone A (2004) Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows. Journal of Dairy Science 87, 2881–2888.
| Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXntlGjsLg%3D&md5=41a926ea6fd3c3ad651b67a1101dd689CAS | 15375048PubMed |
Bernabucci U, Ronchi B, Lacetera N, Nardone A (2005) Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science 88, 2017–2026.
| Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXksFyrtbo%3D&md5=9b723144eec1d7537da9e17efd0c733dCAS | 15905432PubMed |
Bertoni G, Calamari L (2006) Valutazione del benessere animale. In ‘Il benessere animale e la qualità delle produzioni nei piccoli ruminanti. Vol. Quaderni 2005-VII’. (Ed. I Georgofili) pp. 33–46. (Avenue Media: Bologna, Italy)
Bertoni G, Calamari L, Trevisi E (1999) Valutazione del benessere delle lattifere. Informatore Agrario 55, 5–66.
Bertoni G, Trevisi E, Calamari L, Bionaz M (2006) The inflammation could have a role in the liver lipidosis occurrence in dairy cows. In ‘12th international conference on production diseases in farm animals, East Lansing, Michigan, USA, 19–22 July 2004’. (Eds NP Joshi, THJN Herdt) pp. 157–158. (Wageningen Academic Publishers: Wageningen, The Netherlands)
Bertoni G, Trevisi E, Han X, Bionaz M (2008) Effects of inflammatory conditions on liver activity in puerperium period and consequences for performance in dairy cows. Journal of Dairy Science 91, 3300–3310.
| Effects of inflammatory conditions on liver activity in puerperium period and consequences for performance in dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtFamsrnO&md5=3cc15a7eceb37412f5bff0f69df6a80dCAS | 18765589PubMed |
Bertoni G, Trevisi E, Lombardelli R (2009) Some new aspects of nutrition, health conditions and fertility of intensively reared dairy cows. Italian Journal of Animal Science 8, 491–518.
Bionaz M, Loor JJ (2012) Ruminant metabolic systems biology: reconstruction and integration of transcriptome dynamics underlying functional responses of tissues to nutrition and physiological state. Gene Regulation and Systems Biology 6, 109–125.
Bionaz M, Trevisi E, Calamari L, Librandi F, Ferrari A, Bertoni G (2007) Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows. Journal of Dairy Science 90, 1740–1750.
| Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXjs1ahsrg%3D&md5=67ca239ef4b615ccdbf6119e4518e3caCAS | 17369214PubMed |
Bionaz M, Periasamy K, Rodriguez-Zas SL, Everts RE, Lewin HA, Hurley WL, Loor JJ (2012a) Old and new stories: revelations from functional analysis of the bovine mammary transcriptome during the lactation cycle. PLoS ONE 7, e33268
| Old and new stories: revelations from functional analysis of the bovine mammary transcriptome during the lactation cycle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XksFGlsbo%3D&md5=726aeccede8337f5b8a8b2c3524a8d4fCAS | 22428004PubMed |
Bionaz M, Periasamy K, Rodriguez-Zas SL, Hurley WL, Loor JJ (2012b) A novel dynamic impact approach (DIA) for functional analysis of time-course omics studies: validation using the bovine mammary transcriptome. PLoS ONE 7, e32455
| A novel dynamic impact approach (DIA) for functional analysis of time-course omics studies: validation using the bovine mammary transcriptome.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XkvVagtbk%3D&md5=e5297524175111c6aba8c8d35de12e30CAS | 22438877PubMed |
Bionaz M, Thering BJ, Loor JJ (2012c) Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-alpha activation. The British Journal of Nutrition 107, 179–191.
| Fine metabolic regulation in ruminants via nutrient-gene interactions: saturated long-chain fatty acids increase expression of genes involved in lipid metabolism and immune response partly through PPAR-alpha activation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtV2qs7s%3D&md5=1e155bf7df9ff7fa9eab6e132ab9a0eeCAS | 21729373PubMed |
Bjerre-Harpøth V, Friggens NC, Thorup VM, Larsen T, Damgaard BM, Ingvartsen KL, Moyes KM (2012) Metabolic and production profiles of dairy cows in response to decreased nutrient density to increase physiological imbalance at different stages of lactation. Journal of Dairy Science 95, 2362–2380.
| Metabolic and production profiles of dairy cows in response to decreased nutrient density to increase physiological imbalance at different stages of lactation.Crossref | GoogleScholarGoogle Scholar | 22541465PubMed |
Bossaert P, Leroy JL, De Vliegher S, Opsomer G (2008) Interrelations between glucose-induced insulin response, metabolic indicators, and time of first ovulation in high-yielding dairy cows. Journal of Dairy Science 91, 3363–3371.
| Interrelations between glucose-induced insulin response, metabolic indicators, and time of first ovulation in high-yielding dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhtFamsrbI&md5=3b360a938ecf82fefc9c68a1f922a635CAS | 18765595PubMed |
Bossaert P, Trevisi E, Opsomer G, Bertoni G, De Vliegher S, Leroy JL (2012) The association between indicators of inflammation and liver variables during the transition period in high-yielding dairy cows: an observational study. Veterinary Journal (London, England) 192, 222–225.
| The association between indicators of inflammation and liver variables during the transition period in high-yielding dairy cows: an observational study.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XmtlKju78%3D&md5=a44c9120b73c2daa0d59522c94180815CAS |
Bradford BJ, Mamedova LK, Minton JE, Drouillard JS, Johnson BJ (2009) Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle. The Journal of Nutrition 139, 1451–1456.
| Daily injection of tumor necrosis factor-{alpha} increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtlWrt7rI&md5=d8850ec58beb836a881e430537c37e8dCAS | 19549751PubMed |
Broom DM (1997) Welfare evaluation. Applied Animal Behaviour Science 54, 21–23.
| Welfare evaluation.Crossref | GoogleScholarGoogle Scholar |
Broom DM (2006) Behaviour and welfare in relation to pathology. Applied Animal Behaviour Science 97, 73–83.
| Behaviour and welfare in relation to pathology.Crossref | GoogleScholarGoogle Scholar |
Broom DM, Fraser AF (2007) ‘Domestic animal behaviour and welfare.’ (CABI: Wallingford, UK)
Broussard SR, Zhou JH, Venters HD, Bluthé RM, Freund GG, Johnson RW, Dantzer R, Kelley KW (2001) At the interface of environment-immune interactions: cytokine and growth-factor receptors. Journal of Animal Science 79, E268–284.
Burke CR, Meier S, McDougall S, Compton C, Mitchell M, Roche JR (2010) Relationships between endometritis and metabolic state during the transition period in pasture-grazed dairy cows. Journal of Dairy Science 93, 5363–5373.
| Relationships between endometritis and metabolic state during the transition period in pasture-grazed dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXnsl2qug%3D%3D&md5=de229d9ef4cfdbab3a350d4faa37d37dCAS | 20965352PubMed |
Calamari L, Bertoni G (2009) Model to evaluate welfare in dairy cow farms. Italian Journal of Animal Science 8, 301–323.
Calder PC (2002) Dietary modification of inflammation with lipids. The Proceedings of the Nutrition Society 61, 345–358.
| Dietary modification of inflammation with lipids.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XnvVSrs7c%3D&md5=5d89f885480b280e9ba0139cdcdbefd0CAS | 12296294PubMed |
Ceciliani F, Ceron JJ, Eckersall PD, Sauerwein H (2012) Acute phase proteins in ruminants. Journal of Proteomics 75, 4207–4231.
| Acute phase proteins in ruminants.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XmvFChtLs%3D&md5=2ca6be9cdbaa1f66372b9b90405e6d19CAS | 22521269PubMed |
Chinetti G, Fruchart JC, Staels B (2000) Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflammation Research 49, 497–505.
| Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXotF2qu74%3D&md5=24fbb8de23c671a51070dc8bfc1116bbCAS | 11089900PubMed |
Conner EM, Grisham MB (1996) Inflammation, free radicals, and antioxidants. Nutrition 12, 274–277.
| Inflammation, free radicals, and antioxidants.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28XkvVCnsr0%3D&md5=ebb60b4a74e155b3aa93513466ac84b1CAS | 8862535PubMed |
Cousins RJ (1985) Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiological Reviews 65, 238–309.
D’haeseleer P (2005) How does gene expression clustering work? Nature Biotechnology 23, 1499–1501.
| How does gene expression clustering work?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXht1yis7%2FL&md5=86a166ed88c5736c0ae24928d7573cfbCAS | 16333293PubMed |
Dann HM, Morin DE, Bollero GA, Murphy MR, Drackley JK (2005) Prepartum intake, postpartum induction of ketosis, and periparturient disorders affect the metabolic status of dairy cows. Journal of Dairy Science 88, 3249–3264.
| Prepartum intake, postpartum induction of ketosis, and periparturient disorders affect the metabolic status of dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXpvFWhsLw%3D&md5=1295ae458454e946373d2bf3515d6bceCAS | 16107415PubMed |
Dann HM, Litherland NB, Underwood JP, Bionaz M, D’Angelo A, McFadden JW, Drackley JK (2006) Diets during far-off and close-up dry periods affect periparturient metabolism and lactation in multiparous cows. Journal of Dairy Science 89, 3563–3577.
| Diets during far-off and close-up dry periods affect periparturient metabolism and lactation in multiparous cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xos1Khtr8%3D&md5=fd9c467c3aa8c41c1258714f52a24183CAS | 16899692PubMed |
Dantzer R (2001) Cytokine-induced sickness behavior: mechanisms and implications. Annals of the New York Academy of Sciences 933, 222–234.
| Cytokine-induced sickness behavior: mechanisms and implications.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXjvVWqtrc%3D&md5=49b8f681a286d54a12c5eba64dd62d6bCAS | 12000023PubMed |
Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews. Neuroscience 9, 46–56.
| From inflammation to sickness and depression: when the immune system subjugates the brain.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhsVGjsbfJ&md5=e2426be42a0ffdc239dd49e48db6dae6CAS | 18073775PubMed |
Douglas GN, Overton TR, Bateman HG, Dann HM, Drackley JK (2006) Prepartal plane of nutrition, regardless of dietary energy source, affects periparturient metabolism and dry matter intake in Holstein cows. Journal of Dairy Science 89, 2141–2157.
| Prepartal plane of nutrition, regardless of dietary energy source, affects periparturient metabolism and dry matter intake in Holstein cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xlt1eqs7Y%3D&md5=75e07063d17afbdd723a586d83879e61CAS | 16702281PubMed |
Drackley JK (1999) ADSA Foundation Scholar Award. Biology of dairy cows during the transition period: the final frontier? Journal of Dairy Science 82, 2259–2273.
| ADSA Foundation Scholar Award. Biology of dairy cows during the transition period: the final frontier?Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1MXnsVGntLY%3D&md5=83fe38ca23cb1b0d382957db3dd0329dCAS | 10575597PubMed |
Drackley J, Overton T, Douglas G (2001) Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science 84, E100–E112.
| Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXlvFalsL0%3D&md5=3227b1fc4467fe6d799a370666c446aeCAS |
Duncan IJH (2004) A concept of welfare based on feelings. In ‘The well-being of farm animals. Challenges and solutions’. (Eds GJ Benson, BE Rollin) pp. 85–101. (Blackwell: Ames, IA)
Elewaut D, DiDonato JA, Kim JM, Truong F, Eckmann L, Kagnoff MF (1999) NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria. Journal of Immunology 163, 1457–1466.
Elsasser TH, Kahl S, Steele NC, Rumsey TS (1997) Nutritional modulation of somatotropic axis-cytokine relationships in cattle: a brief review. Comparative Biochemistry and Physiology. Part A, Physiology 116, 209–221.
| Nutritional modulation of somatotropic axis-cytokine relationships in cattle: a brief review.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2s3islKhtQ%3D%3D&md5=6bb65be4efa394d05fa80ad19743e55cCAS | 9102185PubMed |
Eskandari F, Webster JI, Sternberg EM (2003) Neural immune pathways and their connection to inflammatory diseases. Arthritis Research & Therapy 5, 251–265.
| Neural immune pathways and their connection to inflammatory diseases.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXptV2nsbg%3D&md5=223af3b1db62291ef2af7a1ce200d5e7CAS |
Etherton TD, Bauman DE (1998) Biology of somatotropin in growth and lactation of domestic animals. Physiological Reviews 78, 745–761.
Fisher MW (2009) Defining animal welfare – does consistency matter? New Zealand Veterinary Journal 57, 71–73.
| Defining animal welfare – does consistency matter?Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD1Mznt1Srsg%3D%3D&md5=a570c0924db1e68abf6157a8b5148e61CAS | 19471323PubMed |
Fleck A (1989) Clinical and nutritional aspects of changes in acute-phase proteins during inflammation. The Proceedings of the Nutrition Society 48, 347–354.
| Clinical and nutritional aspects of changes in acute-phase proteins during inflammation.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK3c7jvFSjtQ%3D%3D&md5=766e527958ddf5130d23632f1792109dCAS | 2482490PubMed |
Fossum C (1998) Cytokines as markers for infections and their effect on growth performance and well-being in the pig. Domestic Animal Endocrinology 15, 439–444.
| Cytokines as markers for infections and their effect on growth performance and well-being in the pig.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXmvVKjt7o%3D&md5=af46fa75dfb68eb2044ba4268529bdaeCAS | 9785048PubMed |
Fraser AF, Broom DM (1990) ‘Farm animal behaviour and welfare.’ (Baillière Tindall: London)
Gates SC, Sweeley CC (1978) Quantitative metabolic profiling based on gas chromatography. Clinical Chemistry 24, 1663–1673.
Goddeeris BM (2010) Understanding nutritional modulation: Th1 versus Th2. In ‘Dynamics in animal nutrition.’ (Eds J Doppenberg, P van der Aar) pp. 15–30. (Wageningen Academic Publishers: Wageningen, The Netherlands)
Goff JP (2006) Major advances in our understanding of nutritional influences on bovine health. Journal of Dairy Science 89, 1292–1301.
| Major advances in our understanding of nutritional influences on bovine health.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xjt1Sjsb8%3D&md5=e3d4fc7a6aadeceaaab35f07025baf08CAS | 16537961PubMed |
Graugnard DE, Bionaz M, Trevisi E, Moyes KM, Salak-Johnson JL, Wallace RL, Drackley JK, Bertoni G, Loor JJ (2012) Blood immunometabolic indices and polymorphonuclear neutrophil function in peripartum dairy cows are altered by level of dietary energy prepartum. Journal of Dairy Science 95, 1749–1758.
| Blood immunometabolic indices and polymorphonuclear neutrophil function in peripartum dairy cows are altered by level of dietary energy prepartum.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XksleisbY%3D&md5=eef7ff1b1ccafe419ad5b29aa0db7062CAS | 22459823PubMed |
Graugnard DE, Moyes KM, Trevisi E, Khan MJ, Keisler D, Drackley JK, Bertoni G, Loor JJ (2013) Liver lipid content and inflammometabolic indices in peripartal dairy cows are altered in response to prepartal energy intake and postpartal intramammary inflammatory challenge. Journal of Dairy Science 96, 918–935.
| Liver lipid content and inflammometabolic indices in peripartal dairy cows are altered in response to prepartal energy intake and postpartal intramammary inflammatory challenge.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhvVKqtbvN&md5=d44c2770719f153939e75d542203c946CAS | 23261380PubMed |
Grimble RF (2001) Stress proteins in disease: metabolism on a knife edge. Clinical Nutrition (Edinburgh, Lothian) 20, 469–476.
| Stress proteins in disease: metabolism on a knife edge.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38XitVSgu70%3D&md5=f3849704df645a026c52a79a67bc725cCAS |
Gruffat D, Durand D, Chilliard Y, Williams P, Bauchart D (1997) Hepatic gene expression of apolipoprotein B100 during early lactation in underfed, high producing dairy cows. Journal of Dairy Science 80, 657–666.
| Hepatic gene expression of apolipoprotein B100 during early lactation in underfed, high producing dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DyaK2s3psVSktA%3D%3D&md5=f808d6daa4ea6415f3762c18d6bcc5d6CAS | 9149960PubMed |
Heilbronn LK, Campbell LV (2008) Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Current Pharmaceutical Design 14, 1225–1230.
| Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXns1yntbg%3D&md5=2eb0b1fbd366d056197e9076ba0ff12dCAS | 18473870PubMed |
Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444, 860–867.
| Inflammation and metabolic disorders.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtlShtrzK&md5=f107f59e689807e2e50036ff51bb6dc7CAS | 17167474PubMed |
Huzzey JM, Nydam DV, Grant RJ, Overton TR (2012) The effects of overstocking Holstein dairy cattle during the dry period on cortisol secretion and energy metabolism. Journal of Dairy Science 95, 4421–4433.
| The effects of overstocking Holstein dairy cattle during the dry period on cortisol secretion and energy metabolism.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtVOlsLjL&md5=296627cdb5830c7b82aacbe238daa9e6CAS | 22818455PubMed |
Ingvartsen KL (2006) Feeding- and management-related diseases in the transition cow. Physiological adaptations around calving and strategies to reduce feeding-related diseases. Animal Feed Science and Technology 126, 175–213.
| Feeding- and management-related diseases in the transition cow. Physiological adaptations around calving and strategies to reduce feeding-related diseases.Crossref | GoogleScholarGoogle Scholar |
Ingvartsen KL, Andersen JB (2000) Integration of metabolism and intake regulation: a review focusing on periparturient animals. Journal of Dairy Science 83, 1573–1597.
| Integration of metabolism and intake regulation: a review focusing on periparturient animals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXltVGgtbw%3D&md5=372dedb148281a7f0c836b482354b83eCAS | 10908064PubMed |
Janovick NA, Drackley JK (2010) Prepartum dietary management of energy intake affects postpartum intake and lactation performance by primiparous and multiparous Holstein cows. Journal of Dairy Science 93, 3086–3102.
| Prepartum dietary management of energy intake affects postpartum intake and lactation performance by primiparous and multiparous Holstein cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVOhtrnO&md5=efb471c92906a2446540826d7171b29dCAS | 20630227PubMed |
Janovick NA, Boisclair YR, Drackley JK (2011) Prepartum dietary energy intake affects metabolism and health during the periparturient period in primiparous and multiparous Holstein cows. Journal of Dairy Science 94, 1385–1400.
| Prepartum dietary energy intake affects metabolism and health during the periparturient period in primiparous and multiparous Holstein cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmvFeitr4%3D&md5=36891e9c6925c91c84ba388a6a580c25CAS | 21338804PubMed |
Janovick-Guretzky NA, Dann HM, Bionaz M, Trevisi E, Bertoni G, Drackley JK (2007) Evaluation of acute phase reactants and indices of liver function in serum from dairy cows fed different levels on energy prepartum. Journal of Dairy Science 90, 408
Ji P, Osorio JS, Drackley JK, Loor JJ (2012) Overfeeding a moderate energy diet prepartum does not impair bovine subcutaneous adipose tissue insulin signal transduction and induces marked changes in peripartal gene network expression. Journal of Dairy Science 95, 4333–4351.
| Overfeeding a moderate energy diet prepartum does not impair bovine subcutaneous adipose tissue insulin signal transduction and induces marked changes in peripartal gene network expression.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtVOls7bJ&md5=17fe2db32a4c91dc160c957b9f6581dbCAS | 22818447PubMed |
Jiang L, Sorensen P, Røntved C, Vels L, Ingvartsen KL (2008) Gene expression profiling of liver from dairy cows treated intra-mammary with lipopolysaccharide. BMC Genomics 9, 443
| Gene expression profiling of liver from dairy cows treated intra-mammary with lipopolysaccharide.Crossref | GoogleScholarGoogle Scholar | 18816405PubMed |
Johnson RW, Finck BN (2001) TNFα and leptin: two players in an animal’s metabolic and immunologic responses to infection. Journal of Animal Science 79, E118–127.
Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, Gabazza EC, Adachi Y (2000) Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. Journal of Gastroenterology 35, 659–664.
| Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3cXmvFOjur4%3D&md5=2ad7a9749c1ca216b52c9425f3cc6170CAS | 11023036PubMed |
Kapcala PL (1999) Inflammatory stress and the immune system. In ‘Nutrition and immune function’. pp. 409–36. (National Academy Press: Washington, DC)
Katoh N (2002) Relevance of apolipoproteins in the development of fatty liver and fatty liver-related peripartum diseases in dairy cows. The Journal of Veterinary Medical Science 64, 293–307.
| Relevance of apolipoproteins in the development of fatty liver and fatty liver-related peripartum diseases in dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xkt12qu7k%3D&md5=f50217bfe55d14ed9ca2b58b35d3b347CAS | 12014573PubMed |
Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, Grunfeld C (2004) Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. Journal of Lipid Research 45, 1169–1196.
| Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXltFyqs78%3D&md5=7e43ca055a9653b62b14698bf8e916d1CAS | 15102878PubMed |
Klein MS, Almstetter MF, Schlamberger G, Nurnberger N, Dettmer K, Oefner PJ, Meyer HH, Wiedemann S, Gronwald W (2010) Nuclear magnetic resonance and mass spectrometry-based milk metabolomics in dairy cows during early and late lactation. Journal of Dairy Science 93, 1539–1550.
| Nuclear magnetic resonance and mass spectrometry-based milk metabolomics in dairy cows during early and late lactation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXms1arurs%3D&md5=eb0340d690a77e03786a97b208d76b86CAS | 20338431PubMed |
Klein MS, Buttchereit N, Miemczyk SP, Immervoll AK, Louis C, Wiedemann S, Junge W, Thaller G, Oefner PJ, Gronwald W (2012) NMR metabolomic analysis of dairy cows reveals milk glycerophosphocholine to phosphocholine ratio as prognostic biomarker for risk of ketosis. Journal of Proteome Research 11, 1373–1381.
| NMR metabolomic analysis of dairy cows reveals milk glycerophosphocholine to phosphocholine ratio as prognostic biomarker for risk of ketosis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsVyrs7zN&md5=3b2b9db2cd1d34b97b7829ebced2baceCAS | 22098372PubMed |
Koutsos EA, Klasing KC (2001) Interactions between the immune system, nutrition, and productivity of animals. In ‘Recent advances in animal nutrition’. (Eds PC Garnsworthy, J Wiseman) pp. 173–90. (Nottingham University Press: Nottingham, UK)
LeBlanc S (2010) Monitoring metabolic health of dairy cattle in the transition period. The Journal of Reproduction and Development 56, S29–S35.
| Monitoring metabolic health of dairy cattle in the transition period.Crossref | GoogleScholarGoogle Scholar | 20629214PubMed |
Litherland NB, Dann HM, Drackley JK (2011) Prepartum nutrient intake alters palmitate metabolism by liver slices from peripartal dairy cows. Journal of Dairy Science 94, 1928–1940.
| Prepartum nutrient intake alters palmitate metabolism by liver slices from peripartal dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXnvFChtbs%3D&md5=4e360d38523cefe2fb81f1bb4de5f9b0CAS | 21426984PubMed |
Liu GE (2011) Recent applications of DNA sequencing technologies in food, nutrition and agriculture. Recent Patents on Food. Nutrition & Agriculture 3, 187–195.
| Recent applications of DNA sequencing technologies in food, nutrition and agriculture.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtlKisbnI&md5=c0b03631c743132cafa26c11ff56c4c4CAS |
Loor JJ (2010) Genomics of metabolic adaptations in the peripartal cow. Animal 4, 1110–1139.
| Genomics of metabolic adaptations in the peripartal cow.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXmvVajtr4%3D&md5=f3921522acedc72e5f5b9a0fbdde3896CAS | 22444613PubMed |
Loor JJ, Dann HM, Everts RE, Oliveira R, Green CA, Guretzky NA, Rodriguez-Zas SL, Lewin HA, Drackley JK (2005) Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function. Physiological Genomics 23, 217–226.
| Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXht1WmsrzE&md5=494982d406d15c26808b91b273fab8eaCAS | 16091418PubMed |
Loor JJ, Dann HM, Guretzky NA, Everts RE, Oliveira R, Green CA, Litherland NB, Rodriguez-Zas SL, Lewin HA, Drackley JK (2006) Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiological Genomics 27, 29–41.
| Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xht1Wgtr7P&md5=0e68c203e7bb0338a90a099cbec991a9CAS | 16757553PubMed |
Loor JJ, Everts RE, Bionaz M, Dann HM, Morin DE, Oliveira R, Rodriguez-Zas SL, Drackley JK, Lewin HA (2007) Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows. Physiological Genomics 32, 105–116.
| Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXmt1WgsLs%3D&md5=e7ca3e100a2745d6aed762af9123ba94CAS | 17925483PubMed |
Lucy MC (2007) Fertility in high-producing dairy cows: reasons for decline and corrective strategies for sustainable improvement. Society of Reproduction and Fertility Supplement 64, 237–254.
Luscombe NM, Greenbaum D, Gerstein M (2001) What is bioinformatics? A proposed definition and overview of the field. Methods of Information in Medicine 40, 346–358.
Maggini S, Wintergerst ES, Beveridge S, Hornig DH (2007) Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. The British Journal of Nutrition 98, S29–S35.
| Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtlGmtr%2FP&md5=2301f7c1e2894191902461e80e7660c0CAS | 17922955PubMed |
Mathis D, Shoelson SE (2011) Immunometabolism: an emerging frontier. Nature Reviews. Immunology 11, 81–83.
| Immunometabolism: an emerging frontier.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXlsFegug%3D%3D&md5=a35f6922899b8abfa53e8affef9baf84CAS | 21469396PubMed |
Matthews LR, Cameron C, Sheahan AJ, Kolver ES, Roche JR (2012) Associations among dairy cow body condition and welfare-associated behavioral traits. Journal of Dairy Science 95, 2595–2601.
| Associations among dairy cow body condition and welfare-associated behavioral traits.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlvFylsL4%3D&md5=c5bbd658c87f6951168c7647b0d4c74bCAS | 22541488PubMed |
McCarthy SD, Waters SM, Kenny DA, Diskin MG, Fitzpatrick R, Patton J, Wathes DC, Morris DG (2010) Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach. Physiological Genomics 42A, 188–199.
| Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmsVSltb0%3D&md5=076ae475d27bbfd3c9c3b2848d685f23CAS | 20716645PubMed |
Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454, 428–435.
| Origin and physiological roles of inflammation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXovV2mtbw%3D&md5=14c907807fe0f1d1da83cfc5f06a4503CAS | 18650913PubMed |
Moraes LA, Piqueras L, Bishop-Bailey D (2006) Peroxisome proliferator-activated receptors and inflammation. Pharmacology & Therapeutics 110, 371–385.
| Peroxisome proliferator-activated receptors and inflammation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28Xks1eksbY%3D&md5=5893cae9f5675339ba3f7d82ecc73cd1CAS |
Morris DG, Waters SM, McCarthy SD, Patton J, Earley B, Fitzpatrick R, Murphy JJ, Diskin MG, Kenny DA, Brass A, Wathes DC (2009) Pleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity. Physiological Genomics 39, 28–37.
| Pleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtlakt7rN&md5=0e37670d31b1b6b422d6e0fc56f17607CAS | 19567785PubMed |
Moshage H (1997) Cytokines and the hepatic acute phase response. The Journal of Pathology 181, 257–266.
| Cytokines and the hepatic acute phase response.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK2sXjtlKktr8%3D&md5=f3cae410c1dbce89d8db4be0029e6581CAS | 9155709PubMed |
Mulligan FJ, Doherty ML (2008) Production diseases of the transition cow. Veterinary Journal (London, England) 176, 3–9.
| Production diseases of the transition cow.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjs1Srsbc%3D&md5=2aeca45c82b3d6969d8697887c1ade5eCAS |
Nicholson G, Rantalainen M, Maher AD, Li JV, Malmodin D, Ahmadi KR, Faber JH, Hallgrimsdottir IB, Barrett A, Toft H, Krestyaninova M, Viksna J, Neogi SG, Dumas ME, Sarkans U, The Molpage Consortium Silverman BW, Donnelly P, Nicholson JK, Allen M, Zondervan KT, Lindon JC, Spector TD, McCarthy MI, Holmes E, Baunsgaard D, Holmes CC (2011) Human metabolic profiles are stably controlled by genetic and environmental variation. Molecular Systems Biology 7, 525
| Human metabolic profiles are stably controlled by genetic and environmental variation.Crossref | GoogleScholarGoogle Scholar | 21878913PubMed |
Nielsen BL (1999) Perceived welfare issues in dairy cattle, with special emphasis on metabolic stress. In ‘Metabolic stress in dairy cows. Occasional publication 24’. (Eds GSJD Oldham, AF Groen, BL Nielsen, JE Pryce, TLJ Lawrence) pp. 1–7. (British Society of Animal Science: Edinburgh, UK)
Osorio JS, Trevisi E, Ji P, Luchini D, Drackley JK, Bertoni G, Loor JJ (2012) Immunometabolic indices in dairy cows supplemented with Smartamine M or MetaSmart during the peripartal period. Journal of Dairy Science 95, T298
Overton TR, Waldron MR (2004) Nutritional management of transition dairy cows: strategies to optimize metabolic health. Journal of Dairy Science 87, E105–119.
| Nutritional management of transition dairy cows: strategies to optimize metabolic health.Crossref | GoogleScholarGoogle Scholar |
Petersen HH, Nielsen JP, Heegaard PM (2004) Application of acute phase protein measurements in veterinary clinical chemistry. Veterinary Research 35, 163–187.
| Application of acute phase protein measurements in veterinary clinical chemistry.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXltlGjur8%3D&md5=a693e27b4d5f882eb0d6a41154c659a4CAS | 15099494PubMed |
Pires JA, Pescara JB, Grummer RR (2007) Reduction of plasma NEFA concentration by nicotinic acid enhances the response to insulin in feed-restricted Holstein cows. Journal of Dairy Science 90, 4635–4642.
| Reduction of plasma NEFA concentration by nicotinic acid enhances the response to insulin in feed-restricted Holstein cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtFWlsrnO&md5=eb4fb6fdc86986673bf5f4cdfab448c8CAS | 17881684PubMed |
Powanda MC (1980) Host metabolic alterations during inflammatory stress as related to nutritional status. American Journal of Veterinary Research 41, 1905–1911.
Pullen DL, Liesman JS, Emery RS (1990) A species comparison of liver slice synthesis and secretion of triacylglycerol from nonesterified fatty acids in media. Journal of Animal Science 68, 1395–1399.
Putri SP, Yamamoto S, Tsugawa H, Fukusaki E (2013) Current metabolomics: technological advances. Journal of Bioscience and Bioengineering in press.
Relling AE, Reynolds CK (2007) Plasma concentrations of gut peptides in dairy cattle increase after calving. Journal of Dairy Science 90, 325–330.
| Plasma concentrations of gut peptides in dairy cattle increase after calving.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXmsFSlsg%3D%3D&md5=6b8415264f0047227e2be2e96d6efd9aCAS | 17183100PubMed |
Reynolds CK, Aikman PC, Lupoli B, Humphries DJ, Beever DE (2003) Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. Journal of Dairy Science 86, 1201–1217.
| Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXjtVajt7w%3D&md5=aff2ca01e7756d72945d04f5b9b73d74CAS | 12741545PubMed |
Rimbach G, Minihane AM, Majewicz J, Fischer A, Pallauf J, Virgli F, Weinberg PD (2002) Regulation of cell signalling by vitamin E. The Proceedings of the Nutrition Society 61, 415–425.
| Regulation of cell signalling by vitamin E.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXovVeqtQ%3D%3D&md5=998d21d31dbd3c70a2d32fc6eda89ff9CAS | 12691170PubMed |
Roche JR (2007) Milk production responses to pre- and postcalving dry matter intake in grazing dairy cows. Livestock Production Science 110, 12–24.
| Milk production responses to pre- and postcalving dry matter intake in grazing dairy cows.Crossref | GoogleScholarGoogle Scholar |
Roche JR, Kolver ES, Kay JK (2005) Influence of precalving feed allowance on periparturient metabolic and hormonal responses and milk production in grazing dairy cows. Journal of Dairy Science 88, 677–689.
| Influence of precalving feed allowance on periparturient metabolic and hormonal responses and milk production in grazing dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXpsFKksA%3D%3D&md5=c68bfce91fcd4cd9b0277ad13fe8119fCAS | 15653535PubMed |
Roche JR, Bell AW, Overton TR, Loor JJ (2013) Nutritional management of the transition cow in the 21st century – a paradigm shift in thinking. Animal Production Science 53, 1000–1023.
| Nutritional management of the transition cow in the 21st century – a paradigm shift in thinking.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXislyrsrw%3D&md5=60b47d27a7a7cebafd4280f6617574f3CAS |
Rollin BE (2004) Annual meeting keynote address: animal agriculture and emerging social ethics for animals. Journal of Animal Science 82, 955–964.
Røntved CM, Andersen JB, Dernfalk J, Ingvartsen KL (2005) Effects of diet energy density and milking frequency in early lactation on tumor necrosis factor-alpha responsiveness in dairy cows. Veterinary Immunology and Immunopathology 104, 171–181.
| Effects of diet energy density and milking frequency in early lactation on tumor necrosis factor-alpha responsiveness in dairy cows.Crossref | GoogleScholarGoogle Scholar | 15734538PubMed |
Rushen J, de Passillé AMB (1998) Behaviour, welfare and productivity of dairy cattle. Canadian Journal of Animal Science 1254, 3–21.
Saleem F, Ametaj BN, Bouatra S, Mandal R, Zebeli Q, Dunn SM, Wishart DS (2012) A metabolomics approach to uncover the effects of grain diets on rumen health in dairy cows. Journal of Dairy Science 95, 6606–6623.
| A metabolomics approach to uncover the effects of grain diets on rumen health in dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsFCltLjL&md5=59962e86145f40b9e04a34d250f57ad5CAS | 22959937PubMed |
Schicho R, Shaykhutdinov R, Ngo J, Nazyrova A, Schneider C, Panaccione R, Kaplan GG, Vogel HJ, Storr M (2012) Quantitative metabolomic profiling of serum, plasma, and urine by (1)H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals. Journal of Proteome Research 11, 3344–3357.
| Quantitative metabolomic profiling of serum, plasma, and urine by (1)H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XmslGru7o%3D&md5=d885f73f1a84c68082f1e53e2293b86fCAS |
Schoenberg KM, Giesy SL, Harvatine KJ, Waldron MR, Cheng C, Kharitonenkov A, Boisclair YR (2011a) Plasma FGF21 is elevated by the intense lipid mobilization of lactation. Endocrinology 152, 4652–4661.
| Plasma FGF21 is elevated by the intense lipid mobilization of lactation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1GrtrvP&md5=27ab684c80b947745db99f369da36768CAS | 21990311PubMed |
Schoenberg KM, Perfield KL, Farney JK, Bradford BJ, Boisclair YR, Overton TR (2011b) Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-alpha and leptin, and adipose tissue gene expression. Journal of Dairy Science 94, 5523–5532.
| Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-alpha and leptin, and adipose tissue gene expression.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtl2qsLrM&md5=ee66f2dda8ebf0fa152157b7dc1fefc2CAS | 22032375PubMed |
Sejersen H, Sorensen MT, Larsen T, Bendixen E, Ingvartsen KL (2012) Liver protein expression in dairy cows with high liver triglycerides in early lactation. Journal of Dairy Science 95, 2409–2421.
| Liver protein expression in dairy cows with high liver triglycerides in early lactation.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlvFyqsrc%3D&md5=194751713624e4b00f77c10a7608082cCAS | 22541469PubMed |
Shahzad K, Loor JJ (2012) Application of top-down and bottom-up systems approaches in ruminant physiology and metabolism. Current Genomics 13, 379–394.
| Application of top-down and bottom-up systems approaches in ruminant physiology and metabolism.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtF2itrfO&md5=bc58f2d371218409904d0a8ba1c2beecCAS | 23372424PubMed |
Sordillo LM, Aitken SL (2009) Impact of oxidative stress on the health and immune function of dairy cattle. Veterinary Immunology and Immunopathology 128, 104–109.
| Impact of oxidative stress on the health and immune function of dairy cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXisVOgtbw%3D&md5=509ec58c8ad35e007c3515c05fea0f82CAS | 19027173PubMed |
Sordillo LM, Contreras GA, Aitken SL (2009) Metabolic factors affecting the inflammatory response of periparturient dairy cows. Animal Health Research Reviews 10, 53–63.
| Metabolic factors affecting the inflammatory response of periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 19558749PubMed |
Sørensen JT, Sandøe P, Halberg N (2001) Animal welfare as one among several values to be considered at farm level: the idea of an ethical account for livestock farming. Acta Agriculturae Scandinavica, Section A. Animal Science (Suppl. 30), 11–16.
Soriani N, Trevisi E, Calamari L (2012) Relationships between rumination time, metabolic conditions, and health status in dairy cows during the transition period. Journal of Animal Science 90, 4544–4554.
Steele MA, Vandervoort G, AlZahal O, Hook SE, Matthews JC, McBride BW (2011) Rumen epithelial adaptation to high-grain diets involves the coordinated regulation of genes involved in cholesterol homeostasis. Physiological Genomics 43, 308–316.
| Rumen epithelial adaptation to high-grain diets involves the coordinated regulation of genes involved in cholesterol homeostasis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmsVSltbc%3D&md5=e7732687ace81d820b7033139f088417CAS | 21245418PubMed |
Stock JL, Shinjo K, Burkhardt J, Roach M, Taniguchi K, Ishikawa T, Kim HS, Flannery PJ, Coffman TM, McNeish JD, Audoly LP (2001) The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure. The Journal of Clinical Investigation 107, 325–331.
| The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXhtVGitb4%3D&md5=755d107ae68da377f7e6f7616b174595CAS | 11160156PubMed |
Suchner U, Kuhn KS, Furst P (2000) The scientific basis of immunonutrition. The Proceedings of the Nutrition Society 59, 553–563.
| The scientific basis of immunonutrition.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3MXhs1ertA%3D%3D&md5=977c545f5a26f91849b019689095e66aCAS | 11115790PubMed |
Sumner JM, McNamara JP (2007) Expression of lipolytic genes in the adipose tissue of pregnant and lactating Holstein dairy cattle. Journal of Dairy Science 90, 5237–5246.
| Expression of lipolytic genes in the adipose tissue of pregnant and lactating Holstein dairy cattle.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXht1Kru73K&md5=5611dc82b263ef15083741567a638111CAS | 17954764PubMed |
Tamminga S, Luteijn PA, Meijer RGM (1997) Changes in composition and energy content of liveweight loss in dairy cows with time after parturition. Livestock Production Science 52, 31–38.
| Changes in composition and energy content of liveweight loss in dairy cows with time after parturition.Crossref | GoogleScholarGoogle Scholar |
Thompson PB (2010) Animal ethics and public expectation: the North American outlook. Journal of Veterinary Medical Education 37, 13–21.
| Animal ethics and public expectation: the North American outlook.Crossref | GoogleScholarGoogle Scholar | 20378872PubMed |
Toso B, Procida G, Stefanon B (2002) Determination of volatile compounds in cows’ milk using headspace GC–MS. The Journal of Dairy Research 69, 569–577.
| Determination of volatile compounds in cows’ milk using headspace GC–MS.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD38Xpt12isrw%3D&md5=9244bd6ad654b8cd97f6df2ae6cc53b1CAS | 12463694PubMed |
Trevisi E, Han X-T, Piccioli-Cappelli F, Bertoni G (2002) Dry matter intake reduction before calving in dairy cows: relationship with immune system and metabolism conditions. In ‘53rd annual meeting of the European Association for Animal Production’. (Ed. Y van der Honing) p. 54. (Wageningen Academic Publishers: Wageningen, The Netherlands)
Trevisi E, Gubbiotti A, Bertoni G (2007) Effects of inflammation in peripartum dairy cows on milk yield, energy balance and efficiency. In ‘3rd European Association for Animal Production International Symposium on Energy and Protein Metabolism and Nutrition’. (Ed. M Crovetto) pp. 395–396. (Wageningen Academic Publishers: Wageningen, The Netherlands)
Trevisi E, Amadori M, Bakudila AM, Bertoni G (2009) Metabolic changes in dairy cows induced by oral, low-dose interferon-alpha treatment. Journal of Animal Science 87, 3020–3029.
| Metabolic changes in dairy cows induced by oral, low-dose interferon-alpha treatment.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtFWjsr7P&md5=bea92791a05a8a384b7648264de9c43fCAS | 19502505PubMed |
Trevisi E, Ferrari A, Piccioli-Cappelli F, Grossi P, Bertoni G (2010a) An additional study on the relationship between the inflammatory condition at calving time and net energy efficiency in dairy cows. In ‘Energy and protein metabolism and nutrition. EAAP publication no. 127’. (Ed. GM Crovetto) pp. 489–90. (Wageningen Academic Publishers: Wageningen, The Netherlands)
Trevisi E, Zecconi A, Bertoni G, Piccinini R (2010b) Blood and milk immune and inflammatory profiles in periparturient dairy cows showing a different liver activity index. The Journal of Dairy Research 77, 310–317.
| Blood and milk immune and inflammatory profiles in periparturient dairy cows showing a different liver activity index.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXnvV2rsLk%3D&md5=d3314403bff30f0874854ddcf134d19dCAS | 20576169PubMed |
Trevisi, E, Amadori, M, Archetti, I, Lacetera, N, Bertoni, G, (2011) Inflammatory response and acute phase proteins in the transition period of high-yielding dairy cows. In ‘Acute phase proteins as early non-specific biomarkers of human and veterinary diseases’. (Ed. F Veas) pp. 355–380. (InTech: Rijeka, Croatia)
Trevisi E, Amadori M, Cogrossi S, Razzuoli E, Bertoni G (2012) Metabolic stress and inflammatory response in high-yielding, periparturient dairy cows. Research in Veterinary Science 93, 695–704.
| Metabolic stress and inflammatory response in high-yielding, periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XpvFCiu70%3D&md5=f3c826b89d2312612c6a26e1739e4056CAS | 22197526PubMed |
Turnbull AV, Rivier CL (1999) Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiological Reviews 79, 1–71.
Van den Top AM, Geelen MJ, Wensing T, Wentink GH, Van ‘t Klooster AT, Beynen AC (1996) Higher postpartum hepatic triacylglycerol concentrations in dairy cows with free rather than restricted access to feed during the dry period are associated with lower activities of hepatic glycerolphosphate acyltransferase. The Journal of Nutrition 126, 76–85.
Veissier I, Boissy A, Capdeville J, Sarignac C (2000) Le bien-être des animaux d’élevage. Comment peut-on le définir et l’évaluer? Point Véterinaire 31, 117–124.
Vels L, Rontved CM, Bjerring M, Ingvartsen KL (2009) Cytokine and acute phase protein gene expression in repeated liver biopsies of dairy cows with a lipopolysaccharide-induced mastitis. Journal of Dairy Science 92, 922–934.
| Cytokine and acute phase protein gene expression in repeated liver biopsies of dairy cows with a lipopolysaccharide-induced mastitis.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXivVakt7w%3D&md5=e8f5afdebcf4b2ff8580e20691266fcdCAS | 19233785PubMed |
Vernon RG (2005) Lipid metabolism during lactation: a review of adipose tissue–liver interactions and the development of fatty liver. The Journal of Dairy Research 72, 460–469.
| Lipid metabolism during lactation: a review of adipose tissue–liver interactions and the development of fatty liver.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFSmtLjF&md5=e021a26227e8be191fab9a3832696f39CAS | 16223462PubMed |
Walker CG, Littlejohn MD, Mitchell MD, Roche JR, Meier S (2012) Endometrial gene expression during early pregnancy differs between fertile and subfertile dairy cow strains. Physiological Genomics 44, 47–58.
| Endometrial gene expression during early pregnancy differs between fertile and subfertile dairy cow strains.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlslOhu7c%3D&md5=4ce976ba7902f24de222bb9223774619CAS | 22045914PubMed |
Wang Z, Gerstein M, Snyder M (2009) RNA-seq: a revolutionary tool for transcriptomics. Nature Reviews. Genetics 10, 57–63.
| RNA-seq: a revolutionary tool for transcriptomics.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXhsFWis7bL&md5=2acc59abf761a6e359c2f22b2baa3d7dCAS | 19015660PubMed |
Wathes DC, Cheng Z, Chowdhury W, Fenwick MA, Fitzpatrick R, Morris DG, Patton J, Murphy JJ (2009) Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows. Physiological Genomics 39, 1–13.
| Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtlakt73F&md5=7aa8d9784cb2c575941c9c314a8c5398CAS | 19567787PubMed |
Watkins LR, Maier SF (2000) The pain of being sick: implications of immune-to-brain communication for understanding pain. Annual Review of Psychology 51, 29–57.
| The pain of being sick: implications of immune-to-brain communication for understanding pain.Crossref | GoogleScholarGoogle Scholar | 1:STN:280:DC%2BD3c3hsFChtg%3D%3D&md5=911b8ba653ed5efa666fd8c244fc7c22CAS | 10751964PubMed |
Weary DM, Huzzey JM, von Keyserlingk MA (2009) Board-invited review: using behavior to predict and identify ill health in animals. Journal of Animal Science 87, 770–777.
| Board-invited review: using behavior to predict and identify ill health in animals.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXisFGnsLk%3D&md5=0961fa916732df335f9b3c299b40f661CAS | 18952731PubMed |
Webster J (1994) ‘Animal welfare. A cool eye towards Eden.’ (Blackwell Science: Oxford, UK)
Weiss WP, Todhunter DA, Hogan JS, Smith KL (1990) Effect of duration of supplementation of selenium and Vitamin E on periparturient dairy cows. Journal of Dairy Science 73, 3187–3194.
| Effect of duration of supplementation of selenium and Vitamin E on periparturient dairy cows.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK3MXhvVCisLw%3D&md5=63b20dbcc69ec857f29459f4b05ce511CAS | 2273147PubMed |
Winckler C (2006) On farm welfare assessment in cattle from basic concepts to feasible assessment systems. In ‘World buiatrics congress, Nice, France’. (Ed. H Havetat, F Schelcher) pp. 493–500. (World Buiatrics Congress: Nice, France)
Wishart DS (2008) Quantitative metabolomics using NMR. TrAC Trends in Analytical Chemistry 27, 228–237.
| Quantitative metabolomics using NMR.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjvF2jtLg%3D&md5=5ae8910549d9d29ddd67e3f90f01fe55CAS |
Wittkopp PJ (2007) Variable gene expression in eukaryotes: a network perspective. The Journal of Experimental Biology 210, 1567–1575.
| Variable gene expression in eukaryotes: a network perspective.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXnt1Gku7c%3D&md5=8b9a1e6a11ab6273979331557c9368f7CAS | 17449821PubMed |
Yao J, Burton JL, Saama P, Sipkovsky S, Coussens PM (2001) Generation of EST and cDNA microarray resources for the study of bovine immunobiology. Acta Veterinaria Scandinavica 42, 391–405.
Zebeli Q, Beitz DC, Bradford BJ, Dunn SM, Ametaj BN (2013) Peripartal alterations of calcitonin gene-related peptide and minerals in dairy cows affected by milk fever. Veterinary Clinical Pathology 42, 70–77.
| Peripartal alterations of calcitonin gene-related peptide and minerals in dairy cows affected by milk fever.Crossref | GoogleScholarGoogle Scholar | 23458656PubMed |
