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RESEARCH ARTICLE

Provider attitudes to the empiric treatment of asymptomatic contacts of gonorrhoea

Sheina Low A , Rick Varma B C , Ruthy McIver B D , Tobias Vickers B C and Anna McNulty A C
+ Author Affiliations
- Author Affiliations

A School of Public Health and Community Medicine, The University of New South Wales, Sydney, NSW 2052, Australia.

B Sydney Sexual Health Centre, Nightingale Wing, Sydney Eye Hospital, 8 Macquarie Street, Sydney, NSW 2000, Australia.

C The Kirby Institute, The University of New South Wales, Sydney, NSW 2052, Australia.

D Corresponding author. Email: ruthy.mciver@health.nsw.gov.au

Sexual Health 17(2) 155-159 https://doi.org/10.1071/SH19165
Submitted: 20 September 2019  Accepted: 13 November 2019   Published: 13 March 2020

Abstract

Background: In the current era of antimicrobial stewardship, the availability of highly sensitive assays and faster turnaround times, the practice of empiric treatment of asymptomatic contacts of gonorrhoea needs review. The views of clinicians in a range of settings across Australia and clinic costs associated with a change of practice was examined. Methods: An online anonymous survey for nurses and doctors working in public sexual health clinics and general practices in urban, regional and rural Australia was developed. Information on the relative importance of a range of factors influencing delivery of empiric treatment was collected. Participants were asked whether current guidelines should change. Results: Surveys were distributed to 468 healthcare providers and 188 (40.2%) fully completed the survey. Most of the participants worked in public practice (84.9%) and 86 (43.2%) were doctors. Factors influencing provision of empiric treatment were: if the patient was unable to return (95.9%) or may not return (95.3%); risk of transmission to others (93.3%); likelihood of infection (88.6%); and patient request (82.9%). Respondents were evenly split as to whether current guidelines should change, with providers in private practice being less likely to support guideline change (P = 0.03). The model of empiric treatment of all asymptomatic sexual contacts was 34% more expensive than a model of testing and treatment of those with a positive result. Conclusion: Currently, the majority of clinicians provide empiric treatment for asymptomatic contacts in Australia. There was significant support for a change in guidelines with specific scenarios requiring individualised responses.

Additional keywords: antimicrobial stewardship, models of care, treatment guidelines.


References

[1]  Wright S, McNulty A. Test positivity in asymptomatic men who have sex with men who present as a contact of gonorrhoea – should we change practice? Poster session presented at Australasian Sexual Health Conference; 14–16 November 2016; Adelaide, SA, Australia. 2016. Available online at: https://www.eiseverywhere.com/file_uploads/fbf10d3be620dcf5d99f031e5bce5501_SimonWright395.pdf [verified 1 January 2020].

[2]  Dutt K, Chow EPF, Huffam S, Klassen K, Fairley CK, Bradshaw CS, et al. High prevalence of rectal gonorrhoea among men reporting contact with men with gonorrhoea: implications for epidemiological treatment. BMC Public Health 2015; 15 658
High prevalence of rectal gonorrhoea among men reporting contact with men with gonorrhoea: implications for epidemiological treatment.Crossref | GoogleScholarGoogle Scholar | 26170131PubMed |

[3]  Pearce E, Chan DJ, Smith DE. Empiric antimicrobial treatment for asymptomatic sexual contacts of sexually transmitted infection in the era of antimicrobial resistance: time to rethink? Int J STD AIDS 2019; 30 137–9.
Empiric antimicrobial treatment for asymptomatic sexual contacts of sexually transmitted infection in the era of antimicrobial resistance: time to rethink?Crossref | GoogleScholarGoogle Scholar | 30293504PubMed |

[4]  Australian Sexual Health Alliance. Australian STI management guidelines. Darlinghurst, NSW, Australia: ASHA; 2018. Available online at: http://www.sti.guidelines.org.au/sexually-transmissible-infections/gonorrhoea#contact-tracing [verified 4 July 2019].

[5]  Australian Bureau of Statistics. Australian Standard Geographical Classification. Belconnen, ACT, Australia: ABS; 2011. Available online at: https://www.abs.gov.au/websitedbs/D3310114.nsf/home/Australian+Standard+Geographical+Classification+(ASGC) [verified 4 July 2019].

[6]  Industrial Relations Commission of New South Wales. Public Health System Nurses’ and midwives’ (state) award 2018. Parramatta, NSW, Australia: Industrial Relations Commission of New South Wales; 2018. Available online at: https://www.health.nsw.gov.au/careers/conditions/Awards/nurses.pdf [verified 4 July 2019].

[7]  Jin J, Sklar GE, Min Sen Oh V, Chuen Li S. Factors affecting therapeutic compliance: a review from the patient’s perspective. Ther Clin Risk Manag 2008; 4 269–86.
| 18728716PubMed |

[8]  World Health Organization (WHO). Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae. Geneva: WHO; 2012.

[9]  Zetts RM, Stoesz A, Smith BA, Hyun DY. Outpatient antibiotic use and the need for increased antibiotic stewardship efforts. Pediatrics 2018; 141 e20174124
Outpatient antibiotic use and the need for increased antibiotic stewardship efforts.Crossref | GoogleScholarGoogle Scholar | 29793986PubMed |

[10]  King LM, Fleming-Dutra KE, Hicks LA. Advances in optimizing the prescription of antibiotics in outpatient settings. BMJ 2018; 363 k3047
Advances in optimizing the prescription of antibiotics in outpatient settings.Crossref | GoogleScholarGoogle Scholar | 30420401PubMed |

[11]  Barry PM, Klausner JD. The use of cephalosporins for gonorrhea: the impending problem of resistance. Expert Opin Pharmacother 2009; 10 555–77.
The use of cephalosporins for gonorrhea: the impending problem of resistance.Crossref | GoogleScholarGoogle Scholar | 19284360PubMed |

[12]  Abraha M, Egli-Gany D, Low N. Epidemiological, behavioural, and clinical factors associated with antimicrobial-resistant gonorrhoea: a review. F1000Res 2018; 7 400
Epidemiological, behavioural, and clinical factors associated with antimicrobial-resistant gonorrhoea: a review.Crossref | GoogleScholarGoogle Scholar | 29636908PubMed |

[13]  Mensforth S, Thorley N, Radcliffe K. Auditing the use and assessing the clinical utility of microscopy as a point-of-care test for Neisseria gonorrhoeae in a sexual health clinic. Int J STD AIDS 2018; 29 157–63.
Auditing the use and assessing the clinical utility of microscopy as a point-of-care test for Neisseria gonorrhoeae in a sexual health clinic.Crossref | GoogleScholarGoogle Scholar | 28705094PubMed |

[14]  Chung P, Scandlyn J, Dayan PS, Mistry RD. Working at the intersection of context, culture, and technology: provider perspectives on antimicrobial stewardship in the emergency department using electronic health record clinical decision support. Am J Infect Control 2017; 45 1198–202.
Working at the intersection of context, culture, and technology: provider perspectives on antimicrobial stewardship in the emergency department using electronic health record clinical decision support.Crossref | GoogleScholarGoogle Scholar | 28711345PubMed |

[15]  Curran JA, Brehaut J, Patey AM, Osmond M, Stiell I, Grimshaw JM. Understanding the Canadian adult CT head rule trial: use of the theoretical domains framework for process evaluation. Implement Sci 2013; 8 25
Understanding the Canadian adult CT head rule trial: use of the theoretical domains framework for process evaluation.Crossref | GoogleScholarGoogle Scholar | 23433082PubMed |

[16]  Curtis K, Fulton E, Brown K. Factors influencing application of behavioural science evidence by public health decision-makers and practitioners, and implications for practice. Prev Med Rep 2018; 12 106–15.
Factors influencing application of behavioural science evidence by public health decision-makers and practitioners, and implications for practice.Crossref | GoogleScholarGoogle Scholar | 30233998PubMed |