The molecular epidemiology of Treponema pallidum subspecies pallidum
Daphne Y. Ma A D , Lorenzo Giacani A B and Arturo Centurión-Lara C E
+ Author Affiliations
- Author Affiliations
A University of Washington, Department of Global Health, 325 9th Avenue, Seattle, WA, 98104, USA.
B University of Washington, Division of Allergy and Infectious Diseases, 325 9th Avenue, Seattle, WA, 98104, USA.
C Universidad Peruana Cayetano Heredia, Facultad de Salud Pública, Avenida Honorio Delgado 430, San Martín de Porres 15102, Lima, Perú.
D Present address: Emory University, Department of Pediatrics, Yerkes Vaccine Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
E Corresponding author. Email: acentur@uw.edu
Sexual Health 12(2) 141-147 https://doi.org/10.1071/SH14197
Submitted: 14 October 2014 Accepted: 18 January 2015 Published: 7 April 2015
Abstract
Pathogens adapt and evolve in response to pressures exerted by host environments, leading to generation of genetically diverse variants. Treponema pallidum subspecies pallidum displays a substantial amount of interstrain diversity. These variants have been identified in various parts of the world, indicating transmission linkage between geographical regions. Genotyping is based on molecular characterisation of various loci in the syphilis treponeme genome, but still require further development and continued research, as new bacterial types are continually being detected. The goal for studying the molecular epidemiology of Treponema pallidum variants is the global monitoring of the transmission of genetically distinct organisms with different drug sensitivities and, potentially, different virulence proprieties.
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