Awareness of and barriers to using non-occupational post-exposure prophylaxis among male clients of female sex workers in two cities of China: a qualitative study
Lin Wang
A , Pengcheng Huai B , Kedi Jiao A , Yicong Liu A , Yumeng Hua A , Xueyuan Liu A , Chongyi Wei C D and Wei Ma A D
+ Author Affiliations
- Author Affiliations
A Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, No. 44 West WenHua Road, Jinan 250012, China.
B Shandong Provincial Hospital for Skin Disease, Shandong First Medical University, Jinan, China.
C Department of Health Behavior, Society and Policy, Rutgers School of Public Health, Piscataway, NJ, USA.
D Corresponding authors. Emails: Chongyi.Wei@rutgers.edu; weima@sdu.edu.cn
Sexual Health 18(3) 239-247 https://doi.org/10.1071/SH20203
Submitted: 9 November 2020 Accepted: 16 March 2021 Published: 21 June 2021
Abstract
Background: Male clients of female sex workers (‘clients’ hereafter) are considered high-risk and potentially a bridge population in the HIV epidemic. Non-occupational post-exposure prophylaxis (nPEP) is a safe and effective but under-utilised public health intervention to prevent HIV transmission. This study aims to explore clients’ awareness of nPEP, intention of uptake, potential barriers to nPEP uptake and adherence, and suggestions for nPEP promotion in China. Methods: We conducted semi-structured in-depth interviews with 20 clients in two Chinese cities in 2018. Participants were recruited through purposive sampling. The content of the interviews was analysed using thematic content analysis in ATLAS.ti. Results: Overall, just a minority of participants were aware of nPEP. A majority expressed willingness to use nPEP. Potential barriers to nPEP uptake and adherence included adverse drug reactions, price, concerns of drug efficacy, privacy issues, and forgetting to take the drugs. Almost all participants expressed the need to promote nPEP among clients. Participants suggested that the promotion of nPEP should be at hospitals, online, and be integrated with HIV/AIDS health education. Conclusions: Our findings suggested that nPEP guidelines should be formulated and implementation strategies should be developed to address barriers to uptake and adherence in order to successfully tap into the potential of nPEP as an effective HIV prevention tool.
Keywords: HIV/AIDS, interviews, HIV prevention, HIV transmission, non-occupational post-exposure prophylaxis, nPEP, male clients, female sex workers, China, thematic content analysis.
References
[1] Joint United Nations Programme on HIV/AIDS (UNAIDS). Fact sheet – World AIDS Day 2020: Global HIV statistics. 2020. Available online at: https://www.unaids.org/sites/default/files/media_asset/UNAIDS_FactSheet_en.pdf[2] National Health and Family Planning Commission of the People’s Republic of China. 2015 China AIDS response progress report. 2015. Available online at: https://www.unaids.org/sites/default/files/country/documents/CHN_narrative_report_2015.pdf
[3] National Health Commission of the People’s Republic of China, Disease Prevention and Control Bureau New progress has been made in the prevention and treatment of HIV/AIDS in China 2019. Chinese Journal of AIDS & STD 2019; 25 1205 [In Chinese]
| New progress has been made in the prevention and treatment of HIV/AIDS in China 2019.Crossref | GoogleScholarGoogle Scholar |
[4] Lu L, Jia M, Ma Y, Yang L, Chen Z, Ho DD, et al The changing face of HIV in China. Nature 2008; 455 609–11.
| The changing face of HIV in China.Crossref | GoogleScholarGoogle Scholar | 18833270PubMed |
[5] Wang L, Wang N, Wang L, Li D, Jia M, Gao X, et al The 2007 estimates for people at risk for and living with HIV in China: progress and challenges. J Acquir Immune Defic Syndr 2009; 50 414–8.
| The 2007 estimates for people at risk for and living with HIV in China: progress and challenges.Crossref | GoogleScholarGoogle Scholar | 19214116PubMed |
[6] Hong Y, Li X. Behavioral studies of female sex workers in China: a literature review and recommendation for future research. AIDS Behav 2008; 12 623–36.
| Behavioral studies of female sex workers in China: a literature review and recommendation for future research.Crossref | GoogleScholarGoogle Scholar | 17694431PubMed |
[7] Huang ZJ, Wang W, Martin MC, Nehl EJ, Smith BD, Wong FY. “Bridge population”: sex workers or their clients? – STI prevalence and risk behaviors of clients of female sex workers in China. AIDS Care 2011; 23 45–53.
| “Bridge population”: sex workers or their clients? – STI prevalence and risk behaviors of clients of female sex workers in China.Crossref | GoogleScholarGoogle Scholar | 21660750PubMed |
[8] Huang Y, Pan S. Government crackdown of sex work in China: responses from female sex workers and implications for their health. Glob Public Health 2014; 9 1067–79.
| Government crackdown of sex work in China: responses from female sex workers and implications for their health.Crossref | GoogleScholarGoogle Scholar | 25226069PubMed |
[9] Zhu J, Yuan R, Hu D, Zhu Z, Wang N, Wang B. HIV prevalence and correlated factors of female sex workers and male clients in a border region of Yunnan Province, China. Int J STD AIDS 2018; 29 424–34.
| HIV prevalence and correlated factors of female sex workers and male clients in a border region of Yunnan Province, China.Crossref | GoogleScholarGoogle Scholar | 28901213PubMed |
[10] Patterson TL, Volkmann T, Gallardo M, Goldenberg S, Lozada R, Semple SJ, et al Identifying the HIV transmission bridge: which men are having unsafe sex with female sex workers and with their own wives or steady partners? J Acquir Immune Defic Syndr 2012; 60 414–20.
| Identifying the HIV transmission bridge: which men are having unsafe sex with female sex workers and with their own wives or steady partners?Crossref | GoogleScholarGoogle Scholar | 22481603PubMed |
[11] Vergidis PI, Falagas ME. Meta-analyses on behavioral interventions to reduce the risk of transmission of HIV. Infect Dis Clin North Am 2009; 23 309–14.
| Meta-analyses on behavioral interventions to reduce the risk of transmission of HIV.Crossref | GoogleScholarGoogle Scholar | 19393911PubMed |
[12] Crepaz N, Marshall KJ, Aupont LW, Jacobs ED, Mizuno Y, Kay LS, et al The efficacy of HIV/STI behavioral interventions for African American females in the United States: a meta-analysis. Am J Public Health 2009; 99 2069–78.
| The efficacy of HIV/STI behavioral interventions for African American females in the United States: a meta-analysis.Crossref | GoogleScholarGoogle Scholar | 19762676PubMed |
[13] Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011; 365 493–505.
| Prevention of HIV-1 infection with early antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar | 21767103PubMed |
[14] Jiang J, Yang X, Ye L, Zhou B, Ning C, Huang J, et al Pre-exposure prophylaxis for the prevention of HIV infection in high risk populations: a meta-analysis of randomized controlled trials. PLoS One 2014; 9 e87674
| Pre-exposure prophylaxis for the prevention of HIV infection in high risk populations: a meta-analysis of randomized controlled trials.Crossref | GoogleScholarGoogle Scholar | 25551587PubMed |
[15] Siedner MJ, Tumarkin E, Bogoch II. HIV post-exposure prophylaxis (PEP). BMJ 2018; 363 k4928
| HIV post-exposure prophylaxis (PEP).Crossref | GoogleScholarGoogle Scholar | 30498074PubMed |
[16] Centers for Disease Control and Prevention Public health service guidelines for the management of health-care worker exposures to HIV and recommendations for postexposure prophylaxis. MMWR Recomm Rep 1998; 47 1–33.
| 9809743PubMed |
[17] Cardo DM, Culver DH, Ciesielski CA, Srivastava PU, Marcus R, Abiteboul D, et al A case-control study of HIV seroconversion in health care workers after percutaneous exposure. N Engl J Med 1997; 337 1485–90.
| A case-control study of HIV seroconversion in health care workers after percutaneous exposure.Crossref | GoogleScholarGoogle Scholar | 9366579PubMed |
[18] Otten RA, Smith DK, Adams DR, Pullium JK, Jackson E, Kim CN, et al Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2). J Virol 2000; 74 9771–5.
| Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2).Crossref | GoogleScholarGoogle Scholar | 11000253PubMed |
[19] García-Lerma JG, Cong ME, Mitchell J, Youngpairoj AS, Zheng Q, Masciotra S, et al Intermittent prophylaxis with oral Truvada protects macaques from rectal SHIV infection. Sci Transl Med 2010; 2 14ra4
| Intermittent prophylaxis with oral Truvada protects macaques from rectal SHIV infection.Crossref | GoogleScholarGoogle Scholar | 20371467PubMed |
[20] Sperling RS, Shapiro DE, Coombs RW, Todd JA, Herman SA, McSherry GD, et al Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. N Engl J Med 1996; 335 1621–9.
| Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant.Crossref | GoogleScholarGoogle Scholar | 8965861PubMed |
[21] Nielsen-Saines K, Watts H, Veloso VG, Bryson YJ, Joao EC, Pilotto JH, et al Three postpartum antiretroviral regimens to prevent intrapartum HIV infection. N Engl J Med 2012; 366 2368–79.
| Three postpartum antiretroviral regimens to prevent intrapartum HIV infection.Crossref | GoogleScholarGoogle Scholar | 22716975PubMed |
[22] Smith DK, Grohskopf LA, Black RJ, Auerbach JD, Veronese F, Struble KA, et al Antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in the United States: recommendations from the U.S. Department of Health and Human Services. MMWR Recomm Rep 2005; 54 1–20.
| 15660015PubMed |
[23] Tan DHS, Hull MW, Yoong D, Tremblay C, O’Byrne P, Thomas R, et al Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis. CMAJ 2017; 189 E1448–58.
| Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis.Crossref | GoogleScholarGoogle Scholar | 29180384PubMed |
[24] Cresswell F, Waters L, Briggs E, Fox J, Harbottle J, Hawkins D, et al UK guideline for the use of HIV post-exposure prophylaxis following sexual exposure, 2015. Int J STD AIDS 2016; 27 713–38.
| UK guideline for the use of HIV post-exposure prophylaxis following sexual exposure, 2015.Crossref | GoogleScholarGoogle Scholar | 27095790PubMed |
[25] Centers for Disease Control and Prevention Announcement: Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV – United States, 2016. MMWR Morb Mortal Wkly Rep 2016; 65 458
| Announcement: Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV – United States, 2016.Crossref | GoogleScholarGoogle Scholar | 27149423PubMed |
[26] National Center for AIDS/STD Control and Prevntion, China CDC. Demonstration meeting on pre- and post-exposure prophylaxis pilot work programme among MSM. 2018. Available online at: http://ncaids.chinacdc.cn/zxzx/zxdteff/201811/t20181109_197022.htm [In Chinese]
[27] Hou J, Wu Y, Xie L, Meng S, Fu R, Zheng H, et al Post-exposure prophylaxis: an underutilized biomedical HIV prevention method among gay, bisexual and other men who have sex with men in China. AIDS Care 2020; 32 1573–80.
| Post-exposure prophylaxis: an underutilized biomedical HIV prevention method among gay, bisexual and other men who have sex with men in China.Crossref | GoogleScholarGoogle Scholar | 32188267PubMed |
[28] Kumar T, Sampsel K, Stiell IG. Two, three, and four-drug regimens for HIV post-exposure prophylaxis in a North American sexual assault victim population. Am J Emerg Med 2017; 35 1798–803.
| Two, three, and four-drug regimens for HIV post-exposure prophylaxis in a North American sexual assault victim population.Crossref | GoogleScholarGoogle Scholar | 28596030PubMed |
[29] Kowalska JD, Pietraszkiewicz E, Firlag-Burkacka E, Horban A. Suspected unexpected and other adverse reactions to antiretroviral drugs used as post-exposure prophylaxis of HIV infection – five-year experience from clinical practice. Arch Med Sci 2018; 14 547–53.
| Suspected unexpected and other adverse reactions to antiretroviral drugs used as post-exposure prophylaxis of HIV infection – five-year experience from clinical practice.Crossref | GoogleScholarGoogle Scholar | 29765441PubMed |
[30] World Health Organization. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach – second edition. 2016. Available online at: https://www.who.int/hiv/pub/arv/arv-2016/en/
[31] Zeng Z, Liu H, Xu J, Lan G, Wang L, Yin W. Demand for non-occupational post-exposure prophylaxis and its influencing factors among 344 men who have sex with men in Guangxi. Chinese Journal of AIDS & STD 2017; 23 620–4. [In Chinese]
| Demand for non-occupational post-exposure prophylaxis and its influencing factors among 344 men who have sex with men in Guangxi.Crossref | GoogleScholarGoogle Scholar |
[32] Zheng Y, Zeng W, Song Y, Liu S, Luo T. Investigation and analysis of non-occupational post-exposure prophylaxis among 74 MSM in Guiyang. Guizhou Medical Journal 2018; 43 1814–6. [In Chinese]
[33] Lin L, Zhang L, Chen Q, Lu Y, Weichen Y. Results of detection of antibody to HIV in outpatients of STD voluntary conselling and testing clinics in Haikou city. China Trop Med 2014; 14 1154–5. [In Chinese]
| Results of detection of antibody to HIV in outpatients of STD voluntary conselling and testing clinics in Haikou city.Crossref | GoogleScholarGoogle Scholar |
[34] Li J, Jia Z, Yang H, Zhu Y, Jin Y, Hu Y. Analysis of prevalence and related factors of HIV and syphilis among male STD clinic attendants in Jinan. Zhongguo Gonggong Weisheng Guanli 2018; 34 308–11. [In Chinese]
| Analysis of prevalence and related factors of HIV and syphilis among male STD clinic attendants in Jinan.Crossref | GoogleScholarGoogle Scholar |
[35] Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Adm Policy Ment Health 2015; 42 533–44.
| Purposeful sampling for qualitative data collection and analysis in mixed method implementation research.Crossref | GoogleScholarGoogle Scholar | 24193818PubMed |
[36] Malterud K, Siersma VD, Guassora AD. Sample size in qualitative interview studies: guided by information power. Qual Health Res 2016; 26 1753–60.
| Sample size in qualitative interview studies: guided by information power.Crossref | GoogleScholarGoogle Scholar | 26613970PubMed |
[37] Vaismoradi M, Turunen H, Bondas T. Content analysis and thematic analysis: implications for conducting a qualitative descriptive study. Nurs Health Sci 2013; 15 398–405.
| Content analysis and thematic analysis: implications for conducting a qualitative descriptive study.Crossref | GoogleScholarGoogle Scholar | 23480423PubMed |
[38] Zeng Z, Li Z, Lan G, Liu H, Xu J, Yin W. Qualitative study on the demand for non-occupational post-exposure prophylaxis among MSM in Guangxi Zhuang Autonomous Region. Chinese Journal of Disease Control & Prevention 2018; 22 1274–7. [In Chinese]
| Qualitative study on the demand for non-occupational post-exposure prophylaxis among MSM in Guangxi Zhuang Autonomous Region.Crossref | GoogleScholarGoogle Scholar |
[39] Mehta SA, Silvera R, Bernstein K, Holzman RS, Aberg JA, Daskalakis DC. Awareness of post-exposure HIV prophylaxis in high-risk men who have sex with men in New York City. Sex Transm Infect 2011; 87 344–8.
| Awareness of post-exposure HIV prophylaxis in high-risk men who have sex with men in New York City.Crossref | GoogleScholarGoogle Scholar | 21357600PubMed |
[40] Lin SY, Lachowsky NJ, Hull M, Rich A, Cui Z, Sereda P, et al Awareness and use of nonoccupational post-exposure prophylaxis among men who have sex with men in Vancouver, Canada. HIV Med 2016; 17 662–73.
| Awareness and use of nonoccupational post-exposure prophylaxis among men who have sex with men in Vancouver, Canada.Crossref | GoogleScholarGoogle Scholar | 27477994PubMed |
[41] Minas B, Laing S, Jordan H, Mak DB. Improved awareness and appropriate use of non-occupational post-exposure prophylaxis (nPEP) for HIV prevention following a multi-modal communication strategy. BMC Public Health 2012; 12 906
| Improved awareness and appropriate use of non-occupational post-exposure prophylaxis (nPEP) for HIV prevention following a multi-modal communication strategy.Crossref | GoogleScholarGoogle Scholar | 23095456PubMed |
[42] Mustanski B, Ryan DT, Sanchez T, Sineath C, Macapagal K, Sullivan PS. Effects of messaging about multiple biomedical and behavioral HIV prevention methods on intentions to use among US MSM: results of an experimental messaging study. AIDS Behav 2014; 18 1651–60.
| Effects of messaging about multiple biomedical and behavioral HIV prevention methods on intentions to use among US MSM: results of an experimental messaging study.Crossref | GoogleScholarGoogle Scholar | 24907778PubMed |
[43] Mitchell JW, Sophus AI, Petroll AE. HIV-negative partnered men’s willingness to use non-occupational post-exposure prophylaxis and associated factors in a U.S. sample of HIV-negative and HIV-discordant male couples. LGBT Health 2016; 3 146–52.
| HIV-negative partnered men’s willingness to use non-occupational post-exposure prophylaxis and associated factors in a U.S. sample of HIV-negative and HIV-discordant male couples.Crossref | GoogleScholarGoogle Scholar | 26789400PubMed |
[44] Bogoch II, Scully EP, Zachary KC, Yawetz S, Mayer KH, Bell CM, et al Patient attrition between the emergency department and clinic among individuals presenting for HIV nonoccupational postexposure prophylaxis. Clin Infect Dis 2014; 58 1618–24.
| Patient attrition between the emergency department and clinic among individuals presenting for HIV nonoccupational postexposure prophylaxis.Crossref | GoogleScholarGoogle Scholar | 24723288PubMed |
[45] Reif S, Wilson E, McAllaster C, Pence B. The relationship of HIV-related stigma and health care outcomes in the US Deep South. AIDS Behav 2019; 23 242–50.
| The relationship of HIV-related stigma and health care outcomes in the US Deep South.Crossref | GoogleScholarGoogle Scholar | 31317363PubMed |
[46] Rueda S, Mitra S, Chen S, Gogolishvili D, Globerman J, Chambers L, et al Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: a series of meta-analyses. BMJ Open 2016; 6 e011453
| Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: a series of meta-analyses.Crossref | GoogleScholarGoogle Scholar | 27412106PubMed |
[47] Ford N, Irvine C, Shubber Z, Baggaley R, Beanland R, Vitoria M, et al Adherence to HIV postexposure prophylaxis: a systematic review and meta-analysis. AIDS 2014; 28 2721–7.
| Adherence to HIV postexposure prophylaxis: a systematic review and meta-analysis.Crossref | GoogleScholarGoogle Scholar | 25493598PubMed |
[48] Malinverni S, Gennotte AF, Schuster M, De Wit S, Mols P, Libois A. Adherence to HIV post-exposure prophylaxis: a multivariate regression analysis of a 5 years prospective cohort. J Infect 2018; 76 78–85.
| Adherence to HIV post-exposure prophylaxis: a multivariate regression analysis of a 5 years prospective cohort.Crossref | GoogleScholarGoogle Scholar | 29074102PubMed |
[49] Roland ME, Neilands TB, Krone MR, Katz MH, Franses K, Grant RM, et al Seroconversion following nonoccupational postexposure prophylaxis against HIV. Clin Infect Dis 2005; 41 1507–13.
| Seroconversion following nonoccupational postexposure prophylaxis against HIV.Crossref | GoogleScholarGoogle Scholar | 16231265PubMed |
[50] Beymer MR, Weiss RE, Bolan RK, Kofron RM, Flynn RP, Pieribone DL, et al Differentiating nonoccupational postexposure prophylaxis seroconverters and non-seroconverters in a community-based clinic in Los Angeles, California. Open Forum Infect Dis 2017; 4 ofx061
| Differentiating nonoccupational postexposure prophylaxis seroconverters and non-seroconverters in a community-based clinic in Los Angeles, California.Crossref | GoogleScholarGoogle Scholar | 28596981PubMed |
[51] Nachega JB, Parienti JJ, Uthman OA, Gross R, Dowdy DW, Sax PE, et al Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: a meta-analysis of randomized controlled trials. Clin Infect Dis 2014; 58 1297–307.
| Lower pill burden and once-daily antiretroviral treatment regimens for HIV infection: a meta-analysis of randomized controlled trials.Crossref | GoogleScholarGoogle Scholar | 24457345PubMed |
[52] Rodríguez AE, Castel AD, Parish CL, Willis S, Feaster DJ, Kharfen M, et al HIV medical providers’ perceptions of the use of antiretroviral therapy as nonoccupational postexposure prophylaxis in 2 major metropolitan areas. J Acquir Immune Defic Syndr 2013; 64 S68–79.
| HIV medical providers’ perceptions of the use of antiretroviral therapy as nonoccupational postexposure prophylaxis in 2 major metropolitan areas.Crossref | GoogleScholarGoogle Scholar | 24126450PubMed |
[53] Donnell D, Mimiaga MJ, Mayer K, Chesney M, Koblin B, Coates T. Use of non-occupational post-exposure prophylaxis does not lead to an increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trial. AIDS Behav 2010; 14 1182–9.
| Use of non-occupational post-exposure prophylaxis does not lead to an increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trial.Crossref | GoogleScholarGoogle Scholar | 20490908PubMed |
[54] Poynten IM, Jin F, Mao L, Prestage GP, Kippax SC, Kaldor JM, et al Nonoccupational postexposure prophylaxis, subsequent risk behaviour and HIV incidence in a cohort of Australian homosexual men. AIDS 2009; 23 1119–26.
| Nonoccupational postexposure prophylaxis, subsequent risk behaviour and HIV incidence in a cohort of Australian homosexual men.Crossref | GoogleScholarGoogle Scholar | 19417578PubMed |
[55] Clayton Merchant R. Nonoccupational HIV postexposure prophylaxis: a new role for the emergency department. Ann Emerg Med 2000; 36 366–75.
| Nonoccupational HIV postexposure prophylaxis: a new role for the emergency department.Crossref | GoogleScholarGoogle Scholar |
[56] Liu AY, Kittredge PV, Vittinghoff E, Raymond HF, Ahrens K, Matheson T, et al Limited knowledge and use of HIV post- and pre-exposure prophylaxis among gay and bisexual men. J Acquir Immune Defic Syndr 2008; 47 241–7.
| Limited knowledge and use of HIV post- and pre-exposure prophylaxis among gay and bisexual men.Crossref | GoogleScholarGoogle Scholar | 18340656PubMed |
[57] Cornelisse VJ, Lal L, Price B, Ryan KE, Bell C, Owen L, et al Interest in switching to on-demand HIV pre-exposure prophylaxis (PrEP) among Australian users of daily PrEP: an online survey. Open Forum Infect Dis 2019; 6 ofz287
| Interest in switching to on-demand HIV pre-exposure prophylaxis (PrEP) among Australian users of daily PrEP: an online survey.Crossref | GoogleScholarGoogle Scholar | 31304192PubMed |
