Bringing new HIV infections to zero – opportunities and challenges offered by antiretroviral-based prevention in Asia, the Pacific and beyond: An overview of this special issue

Iryna B. Zablotska; Bill Whittaker; John de Wit; Adeeba Kamarulzaman; Jintanat Ananworanich; Edwina Wright; Isobel Mary Poynten; Kenneth Mayer

doi:10.1071/SH14071

EDITORIAL

Bringing new HIV infections to zero – opportunities and challenges offered by antiretroviral-based prevention in Asia, the Pacific and beyond: An overview of this special issue

Iryna B. Zablotska ^A ^M , Bill Whittaker ^B ^C , John de Wit ^D , Adeeba Kamarulzaman ^E , Jintanat Ananworanich ^F ^K ^L , Edwina Wright ^G , Isobel Mary Poynten ^A and Kenneth Mayer ^H ^I ^J

+ Author Affiliations

- Author Affiliations

^A Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, NSW, Australia.

^B National Association of People with HIV (NAPWA), Sydney, NSW 2042, Australia.

^C Pacific Friends of the Global Fund to Fight AIDS, TB and Malaria, Sydney, NSW 2010, Australia.

^D Centre for Social Research in Health, University of New South Wales, Sydney, NSW 2052, Australia.

^E Centre of Excellence for Research in AIDS, University of Malaya, Kuala Lumpur 59990, Malaysia.

^F The Thai Red Cross AIDS Research Center, Bangkok 10330, Thailand.

^G The Alfred Hospital and Burnet Institute, Melbourne, Vic. 3004, Australia.

^H Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

^I Harvard Medical School and School of Public Health, Boston, MA 02115, USA.

^J The Fenway Institute, Fenway Health, Boston, MA02115, USA.

^K US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

^L Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.

^M Corresponding author. Email: izablotska@kirby.unsw.edu.au

Sexual Health 11(2) 97-100 https://doi.org/10.1071/SH14071
Submitted: 8 April 2014 Accepted: 9 April 2014 Published: 14 July 2014

Abstract

This editorial to the special issue of Sexual Health on antiretroviral-based prevention of HIV infection is dedicated to showcasing research and practice in this area. It aims to promote debate regarding the potential of new antiretroviral-based prevention approaches and the challenges encountered in moving prevention innovations into the community. This special issue covers the breadth of innovative HIV prevention research, including that undertaken in the fields of epidemiology, clinical research, social and behavioural science, public health and policy analysis, and with special emphasis on Asia and the Pacific region. Most importantly, it provides an indication of how the region is progressing towards embracing new prevention approaches to combat HIV epidemics across the region.

References

[1] Grant RM, Wainberg MA. Chemoprophylaxis of HIV infection: moving forward with caution. J Infect Dis 2006; 194 874–6.
| Chemoprophylaxis of HIV infection: moving forward with caution.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtFSgt7%2FK&md5=4ea9c12d18bfbba07e86cf0126f5d522CAS | 16960773PubMed |

[2] Choopanya K, Martin M, Suntharasamai P, Sangkum U, Mock PA, Leethochawalit M, et al Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2013; 381 2083–90.
| Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial.Crossref | GoogleScholarGoogle Scholar | 23769234PubMed |

[3] Baeten JM, Donnell D, Ndase P, Mugo NR, Campbell JD, Wangisi J, et al Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med 2012; 367 399–410.
| Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhtlSltrbK&md5=a5af5fd342ef83c6f44d86a4b399fe7bCAS | 22784037PubMed |

[4] Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011; 365 493–505.
| Prevention of HIV-1 infection with early antiretroviral therapy.Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhtVars7jF&md5=f28f0bc4d943ad7366817444e30a0eaeCAS | 21767103PubMed |

[5] Padian NS, McCoy SI, Karim SS, Hasen N, Kim J, Bartos M, et al HIV prevention transformed: the new prevention research agenda. Lancet 2011; 378 269–78.
| HIV prevention transformed: the new prevention research agenda.Crossref | GoogleScholarGoogle Scholar | 21763938PubMed |

[6] The Joint United Nations Programme on HIV/AIDS (UNAIDS). Global fact sheet. Geneva: UNAIDS; 2012. Available online at: http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2012/gr2012/20121120_factsheet_global_en.pdf [verified May 2014].

[7] Whittaker B. Transforming Australia’s HIV prevention and treatment efforts to achieve an AIDS-free generation: the United Nations Political Declaration on HIV/AIDS and the Melbourne Declaration ‘Action on HIV’. Sex Health 2014; 11 101–6.
| Transforming Australia’s HIV prevention and treatment efforts to achieve an AIDS-free generation: the United Nations Political Declaration on HIV/AIDS and the Melbourne Declaration ‘Action on HIV’.Crossref | GoogleScholarGoogle Scholar |

[8] Cassell MM, Holtz TH, Wolfe MI, Hahn M, Prybylski DP. ‘Getting to zero’ in Asia and the Pacific through more strategic use of antiretrovirals for HIV prevention. Sex Health 2014; 11 107–18.
| ‘Getting to zero’ in Asia and the Pacific through more strategic use of antiretrovirals for HIV prevention.Crossref | GoogleScholarGoogle Scholar |

[9] Phuphuakrat A, Kiertiburanakul S, Sungkanuparph S. Current status of HIV treatment in Asia and the Pacific region. Sex Health 2014; 11 119–25.
| Current status of HIV treatment in Asia and the Pacific region.Crossref | GoogleScholarGoogle Scholar |

[10] Lo YR, Kato M, Phanupak N, Fujita M, Duc DB, Sopheap S, et al Challenges and potential barriers to the uptake of ARV-based prevention in Asia and the Pacific region. Sex Health 2014; 11 126–36.
| Challenges and potential barriers to the uptake of ARV-based prevention in Asia and the Pacific region.Crossref | GoogleScholarGoogle Scholar |

[11] de Wit JBF, Adam PCG. Can treatment-based HIV prevention curb the epidemic among gay and other men who have sex with men? A narrative synthesis of increasing evidence for moderating and countervailing effects. Sex Health 2014; 11 137–45.
| Can treatment-based HIV prevention curb the epidemic among gay and other men who have sex with men? A narrative synthesis of increasing evidence for moderating and countervailing effects.Crossref | GoogleScholarGoogle Scholar |

[12] Jansson J, Kerr CC, Wilson DP. Predicting the population impact of increased HIV testing and treatment in Australia. Sex Health 2014; 11 146–54.
| Predicting the population impact of increased HIV testing and treatment in Australia.Crossref | GoogleScholarGoogle Scholar |

[13] Anderson PL, Glidden DV, Liu A, Buchbinder S, Lama JR, Guanira JV, et al Emtricitabine–tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men. Science Translational Medicine 2012; 4 151ra125
| Emtricitabine–tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men.Crossref | GoogleScholarGoogle Scholar | 22972843PubMed |

[14] US Centers for Disease Control and Prevention. Update to interim guidance for pre-exposure prophylaxis (PrEP) for the prevention of HIV infection: PrEP for injecting drug users. MMWR Morb Mortal Wkly Rep 2013; 62 463–5.
| 23760186PubMed |

[15] Amico KR. The key role of adherence for the effectiveness of antiretroviral-based prevention: state of the science and implications for Asia-Pacific region. Sex Health 2014; 11 155–65.
| The key role of adherence for the effectiveness of antiretroviral-based prevention: state of the science and implications for Asia-Pacific region.Crossref | GoogleScholarGoogle Scholar |

[16] Holt M. HIV pre-exposure prophylaxis and treatment as prevention: a review of awareness and acceptability among men who have sex with men in the Asia-Pacific region and the Americas. Sex Health 2014; 11 166–70.
| HIV pre-exposure prophylaxis and treatment as prevention: a review of awareness and acceptability among men who have sex with men in the Asia-Pacific region and the Americas.Crossref | GoogleScholarGoogle Scholar |

[17] Down I, Prestage G, Triffitt K, Brown G,, Bradley J, Ellard J. Recently diagnosed gay men talk about HIV treatment decisions. Sex Health 2014; 11 200–6.
| Recently diagnosed gay men talk about HIV treatment decisions.Crossref | GoogleScholarGoogle Scholar |

[18] Chandhiok N, Joshi SN, Gangakhedkar R. Acceptability of oral and topical HIV chemoprophylaxis in India: implications for at-risk women and men who have sex with men. Sexual Health 2014; 11 171–9.
| Acceptability of oral and topical HIV chemoprophylaxis in India: implications for at-risk women and men who have sex with men.Crossref | GoogleScholarGoogle Scholar |

[19] van Griensven F, Phanuphak N, Srithanaviboonchai K. Biomedical HIV prevention research and epidemic control in Thailand: two sides of the same coin. Sex Health 2014; 11 180–99.
| Biomedical HIV prevention research and epidemic control in Thailand: two sides of the same coin.Crossref | GoogleScholarGoogle Scholar |

[20] Dallabetta G, Chandrasekaran P, Wheeler T, Das A, Ramakrishanan L, Kumta S, et al Rolling out new biomedical HIV prevention tools: what can be learned from Avahan, the India AIDS Initiative? Sex Health 2014; 11 207–16.
| Rolling out new biomedical HIV prevention tools: what can be learned from Avahan, the India AIDS Initiative?Crossref | GoogleScholarGoogle Scholar |

[21] The Joint United Nations Programme on HIV/AIDS (UNAIDS). Regional fact sheet 2012: Asia and the Pacific. Geneva: UNAIDS Communications; 2012. Available online at: http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2012/gr2012/2012_FS_regional_asia_pacific_en.pdf [verified May 2014].

[22] The Joint United Nations Programme on HIV/AIDS (UNAIDS). Sex work and the law in Asia and the Pacific. Report. Geneva: UNAIDS; 2013. Available online at: http://www.undp.org/content/undp/en/home/presscenter/pressreleases/2012/10/18/new-un-report-takes-a-stark-look-at-links-between-sex-work-hiv-and-the-law-in-asia-and-the-pacific/ [verified 19 May 2014].

[23] Global Commission on Drug Policy. The war on drugs and HIV/AIDS: how the criminalization of drug use fuels the global pandemic. Rio de Janeiro: Global Commission on Drug Policy; 2012. Available online at: http://www.globalcommissionondrugs.org/reports/ [verified 19 May 2014].

[24] Reid G, Devaney ML, Baldwin S. Harm reduction programmes in the Asia–Pacific region. Drug Alcohol Rev 2008; 27 95–8.
| Harm reduction programmes in the Asia–Pacific region.Crossref | GoogleScholarGoogle Scholar | 18034387PubMed |

[25] The Joint United Nations Programme on HIV/AIDS (UNAIDS). Country ownership for a sustainable AIDS response: from principles to practice. Discussion paper. Geneva: UNAIDS; 2012. Available online at: http://www.unaids.org/en/media/unaids/contentassets/documents/unaidspublication/2012/20120717_JC2134_UNAIDS_Country_Ownership_Discussion_Paper.pdf [verified May 2014].