Notch signalling regulates steroidogenesis in mouse ovarian granulosa cells
Yishu Wang A , Enhang Lu A , Riqiang Bao A , Ping Xu B , Fen Feng C , Weihui Wen D , Qiming Dong A , Chuan Hu C , Li Xiao C , Min Tang C , Gang Li C , Jing Wang D and Chunping Zhang C E
+ Author Affiliations
- Author Affiliations
A Joint Program of Nanchang University and Queen Mary University of London, School of Medicine, Nanchang University, #461 Bayi Avenue, Nanchang, Jiangxi 330006, PR China.
B Second Clinical College, School of Medicine, Nanchang University, #461 Bayi Avenue, Nanchang, Jiangxi 330006, PR China.
C Department of Cell Biology, School of Medicine, Nanchang University, #461 Bayi Avenue, Nanchang, Jiangxi 330006, PR China.
D Department of Microbiology, School of Medicine, Nanchang University, #461 Bayi Avenue, Nanchang, Jiangxi 330006, PR China.
E Corresponding author. Email: zhangcp81@163.com
Reproduction, Fertility and Development 31(6) 1091-1103 https://doi.org/10.1071/RD18281
Submitted: 12 June 2018 Accepted: 17 January 2019 Published: 4 March 2019
Abstract
The Notch signalling pathway in the mammalian ovary regulates granulosa cell proliferation. However, the effects of Notch signalling on steroidogenesis are unclear. In this study we cultured mouse ovarian granulosa cells from preantral follicles in vitro and observed the effect of Notch signalling on steroidogenesis through overexpression, knockdown and inhibition of Notch signalling. Activation of Notch signalling decreased progesterone and oestrogen secretion. In contrast, inhibition of Notch signalling increased the production of progesterone and oestrogen. Expression of the genes for steroidogenic-related enzymes, including 3β-hydroxysteroid dehydrogenase, p450 cholesterol side-chain cleavage enzyme and aromatase, was repressed after stimulation of Notch signalling. The expression of upstream transcription factors, including steroidogenic factor 1 (SF1), Wilms’ tumour 1 (Wt1), GATA-binding protein 4 (Gata4) and Gata6, was also inhibited after stimulation of Notch signalling. Production of interleukin (IL)-6 was positively correlated with Notch signalling and negatively correlated with the expression of these transcription factors and enzymes. In conclusion, Notch signalling regulated progesterone and oestrogen secretion by affecting the expression of upstream transcription factors SF1, Wt1, Gata4 and Gata6, as well as downstream steroidogenic-related enzymes. IL-6, which may be regulated directly by Notch signalling, may contribute to this process. Our findings add to the understanding of the diverse functions of Notch signalling in the mammalian ovary.
Additional keywords: interleukin-6, oestrogen, progesterone.
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