Calorie restriction during gestation affects ovarian reserve in offspring in the mouse
Bianka M. Zanini A , Kelvin R. S. Andrade A , Jorgea Pradiee A , Gabriel B. Veiga A , Driele N. Garcia B , Rafael G. Mondadori C , Luís A. X. Cruz C , Joao A. Alvarado-Rincón D , Renata P. Ramirez A , Tatiana D. Saccon B , Michal M. Masternak E , Carlos C. Barros A and Augusto Schneider
A F
+ Author Affiliations
- Author Affiliations
A Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
B Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
C Instituto de Biologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
D Faculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
E Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, USA.
F Corresponding author. Email: augusto.schneider@ufpel.edu.br
Reproduction, Fertility and Development 32(18) 1338-1349 https://doi.org/10.1071/RD20107
Submitted: 17 April 2020 Accepted: 27 October 2020 Published: 27 November 2020
Abstract
The aim of this study was to investigate the effect of calorie restriction (CR) during pregnancy in mice on metabolism and ovarian function in the offspring. Pregnant female mice were divided into two groups, a control group and a CR group (n = 7 in each). Mice in the CR group were fed 50% of the amount consumed by control females from Day 10 of gestation until delivery. After weaning, the offspring received diet ad libitum until 3 months of age, when ovaries were collected. Ovaries were serially cut and every sixth section was used for follicle counting. Female offspring from CR dams tended to have increased bodyweight compared with offspring from control females (P = 0.08). Interestingly, fewer primordial follicles (60% reduction; P = 0.001), transitional follicles (P = 0.0006) and total follicles (P = 0.006) were observed in offspring from CR mothers. The number of primary, secondary and tertiary follicles did not differ between the groups (P > 0.05). The CR offspring had fewer DNA double-strand breaks in primary follicle oocytes (P = 0.03). In summary, CR during the second half of gestation decreased primordial ovarian follicle reserve in female offspring. These findings suggest that undernutrition during the second half of gestation may decrease the reproductive lifespan of female offspring.
Keywords: calorie restriction, diet, intrauterine, primordial follicles.
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