Bovine scavenger receptor class A (SR-A) exhibit specific patterns of regulation in the endometrium during the oestrous cycle and early pregnancy
A. Vitorino Carvalho A D G , C. Eozenou A E , C. Richard A , N. Forde B , G. D. Healey C , C. Giraud-Delville A , N. Mansouri-Attia A F , P. Lonergan B , I. M. Sheldon C and O. Sandra A
+ Author Affiliations
- Author Affiliations
A UMR BDR, INRA, ENVA, Université Paris Saclay, 78350, Jouy en Josas, France.
B School of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
C Institute of Life Science, Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
D Present address: BOA, INRA, Université de Tours, 37380 Nouzilly, France.
E Present address: Human Developmental Genetics, Institut Pasteur, Paris, 75724, France.
F Present address: Braverman IVF and Reproductive Immunology, 888 Park Avenue, New York City, NY 10075, USA.
G Corresponding author. Email: anais.carvalho@hotmail.fr
Reproduction, Fertility and Development 31(6) 1078-1090 https://doi.org/10.1071/RD18411
Submitted: 11 October 2018 Accepted: 14 January 2019 Published: 29 March 2019
Abstract
In mammals, tight regulation of maternal endometrial function is critical for pregnancy success. In bovine species, endometrial expression of members of the scavenger receptor class A (SR-A) has been listed in high-throughput analyses, but very little is known about the involvement of these immune factors during implantation in mammals. To provide first insights into the contribution of SR-A to endometrial physiology, we analysed the expression and regulation of all members of SR-A (SR-A1, SR-A3–SR-A6) during the oestrous cycle and early pregnancy in cattle. Levels of SR-A1 were increased on Day 20 of pregnancy, whereas SR-A3 levels were increased on Day 13 of the oestrous cycle and of the pregnancy. Although SR-A4 levels were reduced on Day 20 of the oestrous cycle, they remained high in pregnant animals. SR-A5 levels increased by Day 13 of the oestrous cycle and decreased on Day 20, but remained high in pregnant animals. Interferon-τ does not affect SR-A gene expression, whereas progesterone regulates the expression of the SR-A3 and SR-A5 transcripts. Endometrial SR-A3 appeared significantly higher in cows carrying in vitro-produced embryos than in AI cows. Our data suggest that members of the SR-A family are involved in endometrial remodelling and regulation of endometrial gland physiology, both processes being critical for implantation in mammals.
Additional keywords: cattle, implantation.
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