Computational modelling of maternal interactions with spermatozoa: potentials and prospects
Mark Burkitt A B , Dawn Walker A , Daniela M. Romano A and Alireza Fazeli B C
+ Author Affiliations
- Author Affiliations
A The Department of Computer Science, University of Sheffield, Sheffield, Regent Court, 211 Portobello, Sheffield S1 4DP, UK.
B Academic Unit of Reproductive and Developmental Medicine, Department of Human Metabolism, The Medical School, University of Sheffield, Level 4, The Jessop Wing, Tree Root Walk, Sheffield S10 2SF, UK.
C Corresponding author. Email: a.fazeli@sheffield.ac.uk
Reproduction, Fertility and Development 23(8) 976-989 https://doi.org/10.1071/RD11032
Submitted: 4 February 2011 Accepted: 12 July 2011 Published: 12 October 2011
Abstract
Understanding the complex interactions between gametes, embryos and the maternal tract is required knowledge for combating infertility and developing new methods of contraception. Here we present some main aspects of spermatozoa interactions with the mammalian oviduct before fertilisation and discuss how computational modelling can be used as an invaluable aid to experimental investigation in this field. A complete predictive computational model of gamete and embryo interactions with the female reproductive tract is a long way off. However, the enormity of this task should not discourage us from working towards it. Computational modelling allows us to investigate aspects of maternal communication with gametes and embryos, which are financially, ethically or practically difficult to look at experimentally. In silico models of maternal communication with gametes and embryos can be used as tools to complement in vivo experiments, in the same way as in vitro and in situ models.
Additional keywords: 3D, agent, oviduct, simulation.
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