Sample extraction and liquid chromatography–tandem mass spectrometry (LC-MS/MS) method development and validation for the quantitative detection of cyanobacterial hepatotoxins and neurotoxins in Singapore’s reservoirs

References

American Public Health Association, American Water Works Association and Water Environment Federation (2012). ‘Standard Methods for the Examination of Water and Wastewater’, 22nd edn. (APHA: Washington DC, USA.)

Aráoz, R., Molgó, J., and De Marsac, N. T. (2010). Neurotoxic cyanobacterial toxins. Toxicon 56, 813–828.
| Neurotoxic cyanobacterial toxins.Crossref | GoogleScholarGoogle Scholar | 19660486PubMed |

Arbella, N. A., O’Callaghan, K., Furey, A., and James, K. J. (2007). Chemistry of cyanobacterial neurotoxins – anatoxin-a: synthetic approaches. In ‘Phycotoxins: Chemistry and Biochemistry’. (Eds L. M. Botana and A. Alfonso.) pp. 119–141. (Wiley Blackwell: Oxford, UK.)

Azevedo, J., Osswald, J., Guilhermino, L., and Vasconcelos, V. (2011). Development and validation of an SPE-HPLC-FL method for the determination of anatoxin-a in water and trout (Oncorhincus mykiss). Analytical Letters 44, 1431–1441.
| Development and validation of an SPE-HPLC-FL method for the determination of anatoxin-a in water and trout (Oncorhincus mykiss).Crossref | GoogleScholarGoogle Scholar |

Bain, P., Burcham, P., Falconer, I., Fontaine, F., Froscio, S., Humpage, A., Neumann, C., Patel, B., Shaw, G., and Wickramasingh, W. (2008). Cylindrospermopsin mechanism of toxicity and genotoxicity – CRC for water quality and treatment project. Research Report number 61, Cooperative Research Centre for Water Quality and Treatment, Adelaide, SA, Australia.

Ballot, A., Krienitz, L., Kotut, K., Wiegand, C., Metcalf, J. S., Codd, G. A., and Pflugmacher, S. (2004). Cyanobacteria and cyanobacterial toxins in three alkaline Rift Valley lakes of Kenya – Lakes Bogoria, Nakuru and Elmenteita. Journal of Plankton Research 26, 925–935.
| Cyanobacteria and cyanobacterial toxins in three alkaline Rift Valley lakes of Kenya – Lakes Bogoria, Nakuru and Elmenteita.Crossref | GoogleScholarGoogle Scholar |

Becker, V., Ihara, P., Yunes, J. S., and Huszar, V. L. M. (2010). Occurrence of anatoxin-a (s) during a bloom of Anabaena crassa in a water-supply reservoir in southern Brazil. Journal of Applied Phycology 22, 235–241.
| Occurrence of anatoxin-a (s) during a bloom of Anabaena crassa in a water-supply reservoir in southern Brazil.Crossref | GoogleScholarGoogle Scholar |

Bellinger, E. G., and Sigee, D. C. (2015). ‘Freshwater Algae: Identification, Enumeration and Use as Bioindicators.’ (Wiley: Hoboken, NJ, USA.)

Berger, C., Ba, N., Gugger, M., Bouvy, M., Rusconi, F., Couté, A., Troussellier, M., and Bernard, C. (2006). Seasonal dynamics and toxicity of Cylindrospermopsis raciborskii in Lake Guiers (Senegal, West Africa). FEMS Microbiology Ecology 57, 355–366.
| Seasonal dynamics and toxicity of Cylindrospermopsis raciborskii in Lake Guiers (Senegal, West Africa).Crossref | GoogleScholarGoogle Scholar | 16907750PubMed |

Bouma-Gregson, K., Kudela, R. M., and Power, M. E. (2018). Widespread anatoxin-a detection in benthic cyanobacterial mats throughout a river network. PLoS One 13, e0197669.
| Widespread anatoxin-a detection in benthic cyanobacterial mats throughout a river network.Crossref | GoogleScholarGoogle Scholar | 29775481PubMed |

Bouvy, M., Pagano, M., and Troussellier, M. (2001). Effects of a cyanobacterial bloom (Cylindrospermopsis raciborskii) on bacteria and zooplankton communities in Ingazeira Reservoir (northeast Brazil). Aquatic Microbial Ecology 25, 215–227.
| Effects of a cyanobacterial bloom (Cylindrospermopsis raciborskii) on bacteria and zooplankton communities in Ingazeira Reservoir (northeast Brazil).Crossref | GoogleScholarGoogle Scholar |

Bownik, A. (2010). Harmful algae: effects of alkaloid cyanotoxins on animal and human health. Toxin Reviews 29, 99–114.
| Harmful algae: effects of alkaloid cyanotoxins on animal and human health.Crossref | GoogleScholarGoogle Scholar |

Briand, J. F., Jacquet, S., Bernard, C., and Humbert, J. F. (2003). Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems. Veterinary Research 34, 361–377.
| Health hazards for terrestrial vertebrates from toxic cyanobacteria in surface water ecosystems.Crossref | GoogleScholarGoogle Scholar | 12911854PubMed |

Brient, L., Lengronne, M., Bormans, M., and Fastner, J. (2009). First occurrence of cylindrospermopsin in freshwater in France. Environmental Toxicology 24, 415–420.
| First occurrence of cylindrospermopsin in freshwater in France.Crossref | GoogleScholarGoogle Scholar | 18825725PubMed |

Bumke-Vogt, C., Mailahn, W., and Chorus, I. (1999). Anatoxin-a and neurotoxic cyanobacteria in German lakes and reservoirs. Environmental Toxicology 14, 117–125.
| Anatoxin-a and neurotoxic cyanobacteria in German lakes and reservoirs.Crossref | GoogleScholarGoogle Scholar |

Carmichael, W. W. (1992). Cyanobacteria secondary metabolites – the cyanotoxins. The Journal of Applied Bacteriology 72, 445–459.
| Cyanobacteria secondary metabolites – the cyanotoxins.Crossref | GoogleScholarGoogle Scholar | 1644701PubMed |

Chapra, S. C., Boehlert, B., Fant, C., Bierman, V. J., Henderson, J., Mills, D., Mas, D. M., Rennels, L., Jantarasami, L., Martinich, J., and Strzepek, K. M. (2017). Climate change impacts on harmful algal blooms in US freshwaters: a screening-level assessment. Environmental Science & Technology 51, 8933–8943.
| Climate change impacts on harmful algal blooms in US freshwaters: a screening-level assessment.Crossref | GoogleScholarGoogle Scholar |

Chatziefthimiou, A. D., Metcalf, J. S., Glover, W. B., Banack, S. A., Dargham, S. R., and Richer, R. A. (2016). Cyanobacteria and cyanotoxins are present in drinking water impoundments and groundwater wells in desert environments. Toxicon 114, 75–84.
| Cyanobacteria and cyanotoxins are present in drinking water impoundments and groundwater wells in desert environments.Crossref | GoogleScholarGoogle Scholar | 26921462PubMed |

Chislock, M. F., Sharp, K. L., and Wilson, A. E. (2014). Cylindrospermopsis raciborskii dominates under very low and high nitrogen-to-phosphorus ratios. Water Research 49, 207–214.
| Cylindrospermopsis raciborskii dominates under very low and high nitrogen-to-phosphorus ratios.Crossref | GoogleScholarGoogle Scholar | 24333522PubMed |

Chiswell, R. K., Shaw, G. R., Eaglesham, G., Smith, M. J., Norris, R. L., Seawright, A. A., and Moore, M. R. (1999). Stability of cylindrospermopsin, the toxin from the cyanobacterium, Cylindrospermopsis raciborskii: effect of pH, temperature, and sunlight on decomposition. Environmental Toxicology 14, 155–161.
| Stability of cylindrospermopsin, the toxin from the cyanobacterium, Cylindrospermopsis raciborskii: effect of pH, temperature, and sunlight on decomposition.Crossref | GoogleScholarGoogle Scholar |

Chorus, I. (Ed.) (2012). ‘Current Approaches to Cyanotoxin Risk Assessment, Risk Management and Regulations in Different Countries.’ (Umweltbundesamt: Dessau-Roßlau, Germany.)

Chorus, I., and Bartram, J. (Eds) (2003). Toxic cyanobacteria in water: a guide to their public health consequences, monitoring and management. WHO/SDE/WSH/03.04/57. (E & FN Spon: London, UK.) Available at https://www.who.int/water_sanitation_health/resourcesquality/toxcyanbegin.pdf [Verified 8 January 2020].

Christoffersen, K., and Kaas, H. (2000). Toxic cyanobacteria in water. A guide to their public health consequences, monitoring, and management. Limnology and Oceanography 45, 1212.
| Toxic cyanobacteria in water. A guide to their public health consequences, monitoring, and management.Crossref | GoogleScholarGoogle Scholar |

Clark, J. M., Schaeffer, B. A., Darling, J. A., Urquhart, E. A., Johnston, J. M., Ignatius, A. R., Myer, M. H., Loftin, K. A., Werdell, P. J., and Stumpf, R. P. (2017). Satellite monitoring of cyanobacterial harmful algal bloom frequency in recreational waters and drinking water sources. Ecological Indicators 80, 84–95.
| Satellite monitoring of cyanobacterial harmful algal bloom frequency in recreational waters and drinking water sources.Crossref | GoogleScholarGoogle Scholar | 30245589PubMed |

Codd, G. A., Steffensen, D. A., Burch, M. D., and Baker, P. D. (1994). Toxic blooms of cyanobacteria in Lake Alexandrina, South Australia – learning from history. Marine and Freshwater Research 45, 731–736.
| Toxic blooms of cyanobacteria in Lake Alexandrina, South Australia – learning from history.Crossref | GoogleScholarGoogle Scholar |

Codd, G. A., Lindsay, J., Young, F. M., Morrison, L. F., and Metcalf, J. S. (2005a). Harmful cyanobacteria. In ‘Harmful Cyanobacteria’. (Eds J. Huisman, H. C. P. Matthijs, and P. M. Visser.) pp. 1–23. (Springer: Dordrecht, Netherlands.)

Codd, G. A., Morrison, L. F., and Metcalf, J. S. (2005b). Cyanobacterial toxins: risk management for health protection. Toxicology and Applied Pharmacology 203, 264–272.
| Cyanobacterial toxins: risk management for health protection.Crossref | GoogleScholarGoogle Scholar | 15737680PubMed |

Dantas, Ê. W., Moura, A. D. N., Bittencourt-Oliveira, M. D. C., Arruda Neto, J. D. D. T., and Cavalcanti, A. D. D. C. (2008). Temporal variation of the phytoplankton community at short sampling intervals in the Mundaú Reservoir, northeastern Brazil. Acta Botanica Brasílica 22, 970–982.
| Temporal variation of the phytoplankton community at short sampling intervals in the Mundaú Reservoir, northeastern Brazil.Crossref | GoogleScholarGoogle Scholar |

Dao, T. S., Do-Hong, L. C., and Wiegand, C. (2010). Chronic effects of cyanobacterial toxins on Daphnia magna and their offspring. Toxicon 55, 1244–1254.
| Chronic effects of cyanobacterial toxins on Daphnia magna and their offspring.Crossref | GoogleScholarGoogle Scholar | 20132836PubMed |

de la Cruz, A. A., Hiskia, A., Kaloudis, T., Chernoff, N., Hill, D., Antoniou, M. G., He, X., Loftin, K., O’Shea, K., Zhao, C., Pelaez, M., and Han, C. (2013). A review on cylindrospermopsin: the global occurrence, detection, toxicity and degradation of a potent cyanotoxin. Environmental Science. Processes & Impacts 15, 1979–2003.
| A review on cylindrospermopsin: the global occurrence, detection, toxicity and degradation of a potent cyanotoxin.Crossref | GoogleScholarGoogle Scholar |

European Commission (2002). 2002/657/EC: Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning performance of analytical methods and the interpretation of results. Official Journal of the European Union 221, 17.8.2002.

Falconer, I. R., and Humpage, A. R. (2006). Cyanobacterial (blue–green algal) toxins in water supplies: cylindrospermopsins. Environmental Toxicology 21, 299–304.
| Cyanobacterial (blue–green algal) toxins in water supplies: cylindrospermopsins.Crossref | GoogleScholarGoogle Scholar | 16841306PubMed |

Farrer, D., Counter, M., Hillwig, R., and Cude, C. (2015). Health-based cyanotoxin guideline values allow for cyanotoxin-based monitoring and efficient public health response to cyanobacterial blooms. Toxins 7, 457–477.
| Health-based cyanotoxin guideline values allow for cyanotoxin-based monitoring and efficient public health response to cyanobacterial blooms.Crossref | GoogleScholarGoogle Scholar | 25664510PubMed |

Fastner, J., Heinze, R., Humpage, A. R., Mischke, U., Eaglesham, G. K., and Chorus, I. (2003). Cylindrospermopsin occurrence in two German lakes and preliminary assessment of toxicity and toxin production of Cylindrospermopsis raciborskii (Cyanobacteria) isolates. Toxicon 42, 313–321.
| Cylindrospermopsin occurrence in two German lakes and preliminary assessment of toxicity and toxin production of Cylindrospermopsis raciborskii (Cyanobacteria) isolates.Crossref | GoogleScholarGoogle Scholar | 14559084PubMed |

Fastner, J., Rücker, J., Stüken, A., Preußel, K., Nixdorf, B., Chorus, I., Köhler, A., and Wiedner, C. (2007). Occurrence of the cyanobacterial toxin cylindrospermopsin in northeast Germany. Environmental Toxicology 22, 26–32.
| Occurrence of the cyanobacterial toxin cylindrospermopsin in northeast Germany.Crossref | GoogleScholarGoogle Scholar | 17295278PubMed |

Fayad, P. B., Roy-Lachapelle, A., Duy, S. V., Prévost, M., and Sauvé, S. (2015). On-line solid-phase extraction coupled to liquid chromatography tandem mass spectrometry for the analysis of cyanotoxins in algal blooms. Toxicon 108, 167–175.
| On-line solid-phase extraction coupled to liquid chromatography tandem mass spectrometry for the analysis of cyanotoxins in algal blooms.Crossref | GoogleScholarGoogle Scholar | 26494036PubMed |

Figueredo, C. C., and Giani, A. (2009). Phytoplankton community in the tropical lake of Lagoa Santa (Brazil): conditions favoring a persistent bloom of Cylindrospermopsis raciborskii. Limnologica 39, 264–272.
| Phytoplankton community in the tropical lake of Lagoa Santa (Brazil): conditions favoring a persistent bloom of Cylindrospermopsis raciborskii.Crossref | GoogleScholarGoogle Scholar |

Fitzgeorge, R. B., Clark, S. A., and Keevil, C. W. (1994) Routes of intoxication. In ‘Detection Methods for Cyanobacterial Toxins’. (Eds G. A. Codd, T. M. Jefferies, C. W. Keevil, and E. Potter.) pp. 69–74. (The Royal Society of Chemistry: Cambridge, UK.)

Fonseca, C., Aureliano, M., Abbas, F., and Furey, A. (2015). Recent insights into anatoxin-a chemical synthesis, biomolecular targets, mechanisms of action and LC-MS detection. In ‘Phycotoxins: Chemistry and Biochemistry’. (Eds L. M. Botana and A. Alfonso.) pp. 137–180. (Wiley-Blackwell: Oxford, UK.)

Gaget, V., Humpage, A. R., Huang, Q., Monis, P., and Brookes, J. D. (2017). Benthic cyanobacteria: a source of cylindrospermopsin and microcystin in Australian drinking water reservoirs. Water Research 124, 454–464.
| Benthic cyanobacteria: a source of cylindrospermopsin and microcystin in Australian drinking water reservoirs.Crossref | GoogleScholarGoogle Scholar | 28787682PubMed |

Graham, J. L., and Loftin, K. A. (2018). Book review: Handbook of cyanobacterial monitoring and cyanotoxin analysis. Limnology and Oceanography Bulletin 27, 61–62.
| Book review: Handbook of cyanobacterial monitoring and cyanotoxin analysis.Crossref | GoogleScholarGoogle Scholar |

Griffiths, D. J., and Saker, M. L. (2003). The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin. Environmental Toxicology 18, 78–93.
| The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin.Crossref | GoogleScholarGoogle Scholar | 12635096PubMed |

Gugger, M., Lenoir, S., Berger, C., Ledreux, A., Druart, J. C., Humbert, J. F., Guette, C., and Bernard, C. (2005). First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis. Toxicon 45, 919–928.
| First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis.Crossref | GoogleScholarGoogle Scholar | 15904687PubMed |

Hester, R. E., Harrison, R. M., Bell, S. G., and Codd, G. A. (1996). Detection, analysis and risk assessment of cyanobacterial toxins. In ‘Agricultural Chemicals and the Environment’. Vol. 5, pp. 109–122. (Royal Society of Chemistry.)10.1039/9781847550088-00109

Ho, T. K. (1995). Random decision forests. In ‘ICDAR ‘95: Proceedings of the Third International Conference on Document Analysis and Recognition’, 14–16 August 1995, Montreal, QC, Canada. Volume 1. pp. 278–282. (IEEE Computer Society: Washington, DC, USA.)

Hoeger, S. J., Shaw, G., Hitzfeld, B. C., and Dietrich, D. R. (2004). Occurrence and elimination of cyanobacterial toxins in two Australian drinking water treatment plants. Toxicon 43, 639–649.
| Occurrence and elimination of cyanobacterial toxins in two Australian drinking water treatment plants.Crossref | GoogleScholarGoogle Scholar | 15109885PubMed |

Huisman, J., Codd, G. A., Paerl, H. W., Ibelings, B. W., Verspagen, J. M., and Visser, P. M. (2018). Cyanobacterial blooms. Nature Reviews. Microbiology 16, 471–483.
| Cyanobacterial blooms.Crossref | GoogleScholarGoogle Scholar | 29946124PubMed |

Huszar, V. L. M., Silva, L. H. S., Marinho, M., Domingos, P., and Sant’Anna, C. L. (2000). Cyanoprokaryote assemblages in eight productive tropical Brazilian waters. Hydrobiologia 424, 67–77.
| Cyanoprokaryote assemblages in eight productive tropical Brazilian waters.Crossref | GoogleScholarGoogle Scholar |

Ibelings, B. W., and Havens, K. E. (2008) Cyanobacterial toxins: a qualitative meta-analysis of concentrations, dosage and effects in freshwater, estuarine and marine biota. In ‘Cyanobacterial Harmful Algal Blooms: State of the Science and Research Needs’. (Ed. H. K. Hudnell.) pp. 675–732. (Springer: New York, NY, USA.)

Ibelings, B. W., Backer, L. C., Kardinaal, W. E. A., and Chorus, I. (2014). Current approaches to cyanotoxin risk assessment and risk management around the globe. Harmful Algae 40, 63–74.
| Current approaches to cyanotoxin risk assessment and risk management around the globe.Crossref | GoogleScholarGoogle Scholar |

Irvine, K., Chua, L., and Eikass, H. S. (2014). The four national taps of Singapore: a holistic approach to water resources management from drainage to drinking water. Journal of Water Management Modeling C375, 12–34.
| The four national taps of Singapore: a holistic approach to water resources management from drainage to drinking water.Crossref | GoogleScholarGoogle Scholar |

Jacoby, J., Burghdoff, M., Williams, G., Read, L., and Hardy, F. J. (2015). Dominant factors associated with microcystins in nine midlatitude, maritime lakes. Inland Waters 5, 187–202.
| Dominant factors associated with microcystins in nine midlatitude, maritime lakes.Crossref | GoogleScholarGoogle Scholar |

James, K. J., Crowley, J., Duphard, J., Lehane, M., and Furey, A. (2007). Anatoxin-a and analogues: discovery, distribution, and toxicology. In ‘Phycotoxins: Chemistry and Biochemistry’. (Eds L. M. Botana and A. Alfonso.) pp. 141–158. (Wiley-Blackwell: Oxford, UK.)

James, K. J., Dauphard, J., Crowley, J., and Furey, A. (2008). Cyanobacterial neurotoxins, anatoxin-a and analogues: detection and analysis. In ‘Seafood and Freshwater Toxins – Pharmacology, Physiology and Detection’, 2nd edn. (Ed. L. Botana.) pp. 809–822. (CRC Press Taylor and Francis Group: Boca Raton, FL, USA.)

Jöhnk, K. D., Huisman, J. E. F., Sharples, J., Sommeijer, B. E. N., Visser, P. M., and Stroom, J. M. (2008). Summer heatwaves promote blooms of harmful cyanobacteria. Global Change Biology 14, 495–512.
| Summer heatwaves promote blooms of harmful cyanobacteria.Crossref | GoogleScholarGoogle Scholar |

Kenesi, G., Shafik, H. M., Kovács, A. W., Herodek, S., and Présing, M. (2009). Effect of nitrogen forms on growth, cell composition and N2 fixation of Cylindrospermopsis raciborskii in phosphorus-limited chemostat cultures. Hydrobiologia 623, 191–202.
| Effect of nitrogen forms on growth, cell composition and N₂ fixation of Cylindrospermopsis raciborskii in phosphorus-limited chemostat cultures.Crossref | GoogleScholarGoogle Scholar |

Khoo, H. W., Yang, S. L., and Goh, C. J. (1977). A preliminary limnological study of Seletar Reservoir. The Proceedings of The Singapore National Academy of Science 6, 1–12.

Kinnear, S. (2010). Cylindrospermopsin: a decade of progress on bioaccumulation research. Marine Drugs 8, 542–564.
| Cylindrospermopsin: a decade of progress on bioaccumulation research.Crossref | GoogleScholarGoogle Scholar | 20411114PubMed |

Komárek, J., and Mareš, J. (2012). An update to modern taxonomy (2011) of freshwater planktic heterocytous cyanobacteria. Hydrobiologia 698, 327–351.
| An update to modern taxonomy (2011) of freshwater planktic heterocytous cyanobacteria.Crossref | GoogleScholarGoogle Scholar |

Koreivienė, J., Anne, O., Kasperovičienė, J., and Burškytė, V. (2014). Cyanotoxin management and human health risk mitigation in recreational waters. Environmental Monitoring and Assessment 186, 4443–4459.
| Cyanotoxin management and human health risk mitigation in recreational waters.Crossref | GoogleScholarGoogle Scholar | 24664523PubMed |

Li, R., Carmichael, W. W., Brittain, S., Eaglesham, G. K., Shaw, G. R., Liu, Y., and Watanabe, M. M. (2001a). First report of the cyanotoxins cylindrospermopsin and deoxycylindrospermopsin from Raphidiopsis curvata (Cyanobacteria). Journal of Phycology 37, 1121–1126.
| First report of the cyanotoxins cylindrospermopsin and deoxycylindrospermopsin from Raphidiopsis curvata (Cyanobacteria).Crossref | GoogleScholarGoogle Scholar |

Li, R., Carmichael, W. W., Brittain, S., Eaglesham, G. K., Shaw, G. R., Mahakhant, A., Noparatnaraporn, N., Yongmanitchai, W., Kaya, K., and Watanabe, M. M. (2001b). Isolation and identification of the cyanotoxin cylindrospermopsin and deoxy-cylindrospermopsin from a Thailand strain of Cylindrospermopsis raciborskii (Cyanobacteria). Toxicon 39, 973–980.
| Isolation and identification of the cyanotoxin cylindrospermopsin and deoxy-cylindrospermopsin from a Thailand strain of Cylindrospermopsis raciborskii (Cyanobacteria).Crossref | GoogleScholarGoogle Scholar | 11223086PubMed |

Lim, M. H., Leong, Y. H., Tiew, K. N., and Seah, H. (2011). Urban stormwater harvesting: a valuable water resource of Singapore. Water Practice and Technology 6, wpt20110067.
| Urban stormwater harvesting: a valuable water resource of Singapore.Crossref | GoogleScholarGoogle Scholar |

Lorenzi, A. S., Cordeiro-Araújo, M. K., Chia, M. A., and do Carmo Bittencourt-Oliveira, M. (2018). Cyanotoxin contamination of semiarid drinking water supply reservoirs. Environmental Earth Sciences 77, 595.
| Cyanotoxin contamination of semiarid drinking water supply reservoirs.Crossref | GoogleScholarGoogle Scholar |

Mantzouki, E., Lürling, M., Fastner, J., de Senerpont Domis, L., Wilk-Woźniak, E., Koreivienė, J., Seelen, L., Teurlincx, S., Verstijnen, Y., Krztoń, W., and Walusiak, E. (2018). Temperature effects explain continental scale distribution of cyanobacterial toxins. Toxins 10, 156.
| Temperature effects explain continental scale distribution of cyanobacterial toxins.Crossref | GoogleScholarGoogle Scholar |

Martens, S. (2017). Handbook of cyanobacterial monitoring and cyanotoxin analysis. Advances in Oceanography and Limnology 8, 242.
| Handbook of cyanobacterial monitoring and cyanotoxin analysis.Crossref | GoogleScholarGoogle Scholar |

McDougall, R. J., and Tandy, M. W. (1993). Coccidian/cyanobacterium-like bodies as a cause of diarrhea in Australia. Pathology 25, 375–378.
| Coccidian/cyanobacterium-like bodies as a cause of diarrhea in Australia.Crossref | GoogleScholarGoogle Scholar | 8165002PubMed |

McGregor, G. B., and Fabbro, L. D. (2000). Dominance of Cylindrospermopsis raciborskii (Nostocales, Cyanoprokaryota) in Queensland tropical and subtropical reservoirs: implications for monitoring and management. Lakes and Reservoirs: Research and Management 5, 195–205.
| Dominance of Cylindrospermopsis raciborskii (Nostocales, Cyanoprokaryota) in Queensland tropical and subtropical reservoirs: implications for monitoring and management.Crossref | GoogleScholarGoogle Scholar |

Méjean, A., Paci, G., Gautier, V., and Ploux, O. (2014). Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria. Toxicon 91, 15–22.
| Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria.Crossref | GoogleScholarGoogle Scholar | 25108149PubMed |

Méjean, A., Mazmouz, R., Essadik, I., and Ploux, O. (2018). Anatoxin-a and analogs: occurrence, biosynthesis and detection. Toxicon 149, 107.
| Anatoxin-a and analogs: occurrence, biosynthesis and detection.Crossref | GoogleScholarGoogle Scholar |

Meriluoto, J., Spoof, L., and Codd, G. A. (Eds) (2017a). ‘Handbook of Cyanobacterial Monitoring and Cyanotoxin Analysis.’ (Wiley: Hoboken, New Jersey, United States)

Meriluoto, J., Blaha, L., Bojadzija, G., Bormans, M., Brient, L., Codd, G. A., Drobac, D., Faassen, E. J., Fastner, J., Hiskia, A., and Ibelings, B. W. (2017b). Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST action and challenges for further research. Advances in Oceanography and Limnology 8, 161–178.
| Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST action and challenges for further research.Crossref | GoogleScholarGoogle Scholar |

Mitrovic, S. M., Hardwick, L., and Dorani, F. (2011). Use of flow management to mitigate cyanobacterial blooms in the Lower Darling River, Australia. Journal of Plankton Research 33, 229–241.
| Use of flow management to mitigate cyanobacterial blooms in the Lower Darling River, Australia.Crossref | GoogleScholarGoogle Scholar |

Mohamed, Z. A. (2016). Harmful cyanobacteria and their cyanotoxins in Egyptian fresh waters – state of knowledge and research needs. African Journal of Aquatic Science 41, 361–368.
| Harmful cyanobacteria and their cyanotoxins in Egyptian fresh waters – state of knowledge and research needs.Crossref | GoogleScholarGoogle Scholar |

Molica, R., Onodera, H., García, C., Rivas, M., Andrinolo, D., Nascimento, S., Meguro, H., Oshima, Y., Azevedo, S., and Lagos, N. (2002). Toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii (Cyanophyceae) isolated from Tabocas Reservoir in Caruaru, Brazil, including demonstration of a new saxitoxin analogue. Phycologia 41, 606–611.
| Toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii (Cyanophyceae) isolated from Tabocas Reservoir in Caruaru, Brazil, including demonstration of a new saxitoxin analogue.Crossref | GoogleScholarGoogle Scholar |

Molica, R. J., Oliveira, E. J., Carvalho, P. V., Costa, A. N., Cunha, M. C., Melo, G. L., and Azevedo, S. M. (2005). Occurrence of saxitoxins and an anatoxin-a(s)-like anticholinesterase in a Brazilian drinking water supply. Harmful Algae 4, 743–753.
| Occurrence of saxitoxins and an anatoxin-a(s)-like anticholinesterase in a Brazilian drinking water supply.Crossref | GoogleScholarGoogle Scholar |

Moreira, C., Azevedo, J., Antunes, A., and Vasconcelos, V. (2013). Cylindrospermopsin: occurrence, methods of detection and toxicology. Journal of Applied Microbiology 114, 605–620.
| Cylindrospermopsin: occurrence, methods of detection and toxicology.Crossref | GoogleScholarGoogle Scholar | 23082903PubMed |

Mowe, M. A., Porojan, C., Abbas, F., Mitrovic, S. M., Lim, R. P., Furey, A., and Yeo, D. C. (2015a). Rising temperatures may increase growth rates and microcystin production in tropical Microcystis species. Harmful Algae 50, 88–98.
| Rising temperatures may increase growth rates and microcystin production in tropical Microcystis species.Crossref | GoogleScholarGoogle Scholar |

Mowe, M. A., Mitrovic, S. M., Lim, R. P., Furey, A., and Yeo, D. C. (2015b). Tropical cyanobacterial blooms: a review of prevalence, problem taxa, toxins and influencing environmental factors. Journal of Limnology 74, 205–224.

National Health and Medical Research Council and National Resource Management Ministerial Council (2011) Australian drinking water guidelines paper 6, national water quality management strategy. NHMRC and NRMMC, Canberra, ACT, Australia.

Paerl, H. W., and Paul, V. J. (2012). Climate change: links to global expansion of harmful cyanobacteria. Water Research 46, 1349–1363.
| Climate change: links to global expansion of harmful cyanobacteria.Crossref | GoogleScholarGoogle Scholar | 21893330PubMed |

Paerl, H. W., Hall, N. S., and Calandrino, E. S. (2011). Controlling harmful cyanobacterial blooms in a world experiencing anthropogenic and climatic-induced change. The Science of the Total Environment 409, 1739–1745.
| Controlling harmful cyanobacterial blooms in a world experiencing anthropogenic and climatic-induced change.Crossref | GoogleScholarGoogle Scholar | 21345482PubMed |

Park, H. D., Kim, B., Kim, E., and Okino, T. (1998). Hepatotoxic microcystins and neurotoxic anatoxin-a in cyanobacterial blooms from Korean lakes. Environmental Toxicology and Water Quality 13, 225–234.
| Hepatotoxic microcystins and neurotoxic anatoxin-a in cyanobacterial blooms from Korean lakes.Crossref | GoogleScholarGoogle Scholar |

Pichardo, S., Cameán, A., and Jos, A. (2017). In vitro toxicological assessment of cylindrospermopsin: a review. Toxins 9, 402.
| In vitro toxicological assessment of cylindrospermopsin: a review.Crossref | GoogleScholarGoogle Scholar |

Poniedziałek, B., Rzymski, P., and Kokociński, M. (2012). Cylindrospermopsin: water-linked potential threat to human health in Europe. Environmental Toxicology and Pharmacology 34, 651–660.
| Cylindrospermopsin: water-linked potential threat to human health in Europe.Crossref | GoogleScholarGoogle Scholar | 22986102PubMed |

Porojan, C., Abbas, F., Mowe, M. A. D., Lehane, M., Mitrovic, S. M., Lim, R. P., Yeo, D. C. J., and Furey, A. (2020). A survey of microcystins in Singapore’s reservoirs using tandem mass spectrometry (LC-MS/MS). Marine and Freshwater Research 71, xx–xx.
| A survey of microcystins in Singapore’s reservoirs using tandem mass spectrometry (LC-MS/MS).Crossref | GoogleScholarGoogle Scholar |

Pouria, S., de Andrade, A., Barbosa, J., Cavalcanti, R. L., Barreto, V. T. S., Ward, C. J., Preiser, W., Poon, G. K., Neild, G. H., and Codd, G. A. (1998). Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet 352, 21–26.
| Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil.Crossref | GoogleScholarGoogle Scholar | 9800741PubMed |

Preußel, K., Chorus, I., and Fastner, J. (2014). Nitrogen limitation promotes accumulation and suppresses release of cylindrospermopsins in cells of Aphanizomenon sp. Toxins 6, 2932–2947.
| Nitrogen limitation promotes accumulation and suppresses release of cylindrospermopsins in cells of Aphanizomenon sp.Crossref | GoogleScholarGoogle Scholar | 25271784PubMed |

Roy-Lachapelle, A., Fayad, P. B., Sinotte, M., Deblois, C., and Sauvé, S. (2014). Total microcystins analysis in water using laser diode thermal desorption–atmospheric pressure chemical ionization–tandem mass spectrometry. Analytica Chimica Acta 820, 76–83.
| Total microcystins analysis in water using laser diode thermal desorption–atmospheric pressure chemical ionization–tandem mass spectrometry.Crossref | GoogleScholarGoogle Scholar | 24745740PubMed |

Rzymski, P., and Poniedziałek, B. (2014). In search of environmental role of cylindrospermopsin: a review on global distribution and ecology of its producers. Water Research 66, 320–337.
| In search of environmental role of cylindrospermopsin: a review on global distribution and ecology of its producers.Crossref | GoogleScholarGoogle Scholar | 25222334PubMed |

Scholz, S. N., Esterhuizen-Londt, M., and Pflugmacher, S. (2017). Rise of toxic cyanobacterial blooms in temperate freshwater lakes: causes, correlations and possible countermeasures. Toxicological and Environmental Chemistry 99, 543–577.
| Rise of toxic cyanobacterial blooms in temperate freshwater lakes: causes, correlations and possible countermeasures.Crossref | GoogleScholarGoogle Scholar |

Shaw, G. R., Sukenik, A., Livne, A., Chiswell, R. K., Smith, M. J., Seawright, A. A., Norris, R. L., Eaglesham, G. K., and Moore, M. R. (1999). Blooms of the cylindrospermopsin containing cyanobacterium, Aphanizomenon ovalisporum (Forti), in newly constructed lakes, Queensland, Australia. Environmental Toxicology 14, 167–177.
| Blooms of the cylindrospermopsin containing cyanobacterium, Aphanizomenon ovalisporum (Forti), in newly constructed lakes, Queensland, Australia.Crossref | GoogleScholarGoogle Scholar |

Sierosławska, A. (2010). Immunotoxic, genotoxic and carcinogenic effects of cyanotoxins. Central European Journal of Immunology 35, 105–110.

Sim, C., Quek, B. S., Shutes, R. B. E., and Goh, K. H. (2013). Management and treatment of landfill leachate by a system of constructed wetlands and ponds in Singapore. Water Science and Technology 68, 1114–1122.
| Management and treatment of landfill leachate by a system of constructed wetlands and ponds in Singapore.Crossref | GoogleScholarGoogle Scholar | 24037164PubMed |

Soares, M. C. S., Huszar, V. L., Miranda, M. N., Mello, M. M., Roland, F., and Lürling, M. (2013). Cyanobacterial dominance in Brazil: distribution and environmental preferences. Hydrobiologia 717, 1–12.
| Cyanobacterial dominance in Brazil: distribution and environmental preferences.Crossref | GoogleScholarGoogle Scholar |

Sotero-Santos, R. B., Carvalho, E. G., Dellamano-Oliveira, M. J., and Rocha, O. (2008). Occurrence and toxicity of an Anabaena bloom in a tropical reservoir (Southeast Brazil). Harmful Algae 7, 590–598.
| Occurrence and toxicity of an Anabaena bloom in a tropical reservoir (Southeast Brazil).Crossref | GoogleScholarGoogle Scholar |

Steffensen, D., Burch, M., Nicholson, B., Drikas, M., and Baker, P. (1999). Management of toxic blue–green algae (cyanobacteria) in Australia. Environmental Toxicology 14, 183–195.
| Management of toxic blue–green algae (cyanobacteria) in Australia.Crossref | GoogleScholarGoogle Scholar |

Stevens, D. K., and Krieger, R. I. (1991). Stability studies on the cyanobacterial nicotinic alkaloid anatoxin-A. Toxicon 29, 167–179.
| Stability studies on the cyanobacterial nicotinic alkaloid anatoxin-A.Crossref | GoogleScholarGoogle Scholar | 1646499PubMed |

Svirčev, Z., Obradović, V., Codd, G. A., Marjanović, P., Spoof, L., Drobac, D., Tokodi, N., Petković, A., Nenin, T., Simeunović, J., and Važić, T. (2016). Massive fish mortality and Cylindrospermopsis raciborskii bloom in Aleksandrovac Lake. Ecotoxicology 25, 1353–1363.
| Massive fish mortality and Cylindrospermopsis raciborskii bloom in Aleksandrovac Lake.Crossref | GoogleScholarGoogle Scholar | 27352231PubMed |

Tan, Y. S., Lee, J. T., and Tan, K. (2009) ‘Clean, Green and Blue.’ (ISEAS Publishing: Singapore.)

Te, S. H., and Gin, K. Y.-H. (2011). The dynamics of cyanobacteria and microcystin production in a tropical reservoir of Singapore. Harmful Algae 10, 319–329.
| The dynamics of cyanobacteria and microcystin production in a tropical reservoir of Singapore.Crossref | GoogleScholarGoogle Scholar |

Walter, J. M., Lopes, F. A., Lopes-Ferreira, M., Vidal, L. M., Leomil, L., Melo, F., de Azevedo, G. S., Oliveira, R., Medeiros, A. J., Melo, A. S., and De Rezende, C. E. (2018). Occurrence of harmful cyanobacteria in drinking water from a severely drought-impacted semi-arid region. Frontiers in Microbiology 9, 176.
| Occurrence of harmful cyanobacteria in drinking water from a severely drought-impacted semi-arid region.Crossref | GoogleScholarGoogle Scholar | 29541063PubMed |

Wong, Y. T., Lim, Y. M., and Chiam-Tai, Y. C. (2011). ‘A Guide to Freshwater Phytoplankton in Singapore Reservoirs.’ (Singapore Science Centre: Singapore.)

Wood, S. A., Biessy, L., and Puddick, J. (2018). Anatoxins are consistently released into the water of streams with Microcoleus autumnalis-dominated (cyanobacteria) proliferations. Harmful Algae 80, 88–95.
| Anatoxins are consistently released into the water of streams with Microcoleus autumnalis-dominated (cyanobacteria) proliferations.Crossref | GoogleScholarGoogle Scholar | 30502816PubMed |

World Health Organisation (2003). Cyanobacterial toxins: Microcystin-LR in drinking-water. Background document for development of WHO guidelines for drinking-water quality. WHO/SDE/WSH/03.04/57. (WHO: Geneva, Switzerland.) Available at https://www.who.int/water_sanitation_health/dwq/chemicals/cyanobactoxins.pdf [Verified 8 January 2020].

Yang, S. L., and Chiam-Tai, Y. C. (1991). Algae and algal blooms in Singapore reservoirs. Public Utilities Board Research Development Journal 3, 17–27.